INT116643

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Context Info
Confidence 0.80
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 4.73
Pain Relevance 3.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pik3cb) signal transduction (Pik3cb) cell adhesion (Pik3cb)
nucleus (Pik3cb) cytoplasm (Pik3cb)
Anatomy Link Frequency
neurons 1
soleus 1
hearts 1
mononuclear cells 1
Pik3cb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 262 100.00 Very High Very High Very High
qutenza 7 99.68 Very High Very High Very High
Opioid 35 98.52 Very High Very High Very High
Arthritis 52 98.24 Very High Very High Very High
IPN 2 93.88 High High
Inflammation 65 91.16 High High
antagonist 91 88.96 High High
nociceptor 1 86.64 High High
MU agonist 4 86.00 High High
Morphine 7 84.72 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 181 99.36 Very High Very High Very High
Arthritis 54 98.24 Very High Very High Very High
Cancer 21 95.04 Very High Very High Very High
Insulin Resistance 43 94.56 High High
Necrosis 7 94.56 High High
Inflammatory Pain 2 93.88 High High
Myocardial Infarction 59 91.28 High High
INFLAMMATION 67 91.16 High High
Diabetic Cardiomyopathies 105 82.20 Quite High
Hyperalgesia 5 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin and NGF induce phosphorylation of the PI3K downstream target AKT (protein kinase B), which is blocked by the PI3K inhibitors LY294002 and wortmannin, indicative of the activation of PI3K by both agents.
Phosphorylation (phosphorylation) of PI3K associated with qutenza
1) Confidence 0.80 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385613 Disease Relevance 0.69 Pain Relevance 1.10
Therefore, we determined whether opioid-induced cardioprotection (OIC) occurs during reperfusion by altering GSK phosphorylation through PI3K and target of rapamycin (TOR).
Phosphorylation (phosphorylation) of PI3K associated with opioid
2) Confidence 0.74 Published 2004 Journal Circ. Res. Section Abstract Doc Link 14976126 Disease Relevance 0.12 Pain Relevance 0.55
We have previously demonstrated that pharmacologically induced phosphorylation of PI3K/Akt in the first few min of reperfusion after a sustained ischemic insult is cardioprotective [14].
Phosphorylation (phosphorylation) of PI3K
3) Confidence 0.43 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC3012213 Disease Relevance 0.13 Pain Relevance 0.14
In the present study, we have found out that NMDA and BDNF receptors are also coupled to GSK3 phosphorylation in granule neurons through both PKC and PI3K/Akt dependent mechanisms.
Phosphorylation (phosphorylation) of PI3K in neurons
4) Confidence 0.39 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.25 Pain Relevance 0.03
-D-ribofuranuronamide; IKK = I Kappa Kinase; IL = interleukin; NF = nuclear factor; PBMNC = peripheral blood mononuclear cells; PBS = phosphate-buffered saline; PI3K = phospahtidylinositol-3 kinase; PKA = Protein Kinase A; PKB/Akt = Protein Kinase B; TNF-?
Phosphorylation (phospahtidylinositol-3 kinase) of PI3K in mononuclear cells
5) Confidence 0.33 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 0.85 Pain Relevance 0.27
The fact that inhibition of AKT phosphorylation by the PI3K inhibitor LY294002 prevents MOR internalization induced by H2S but not by DAMGO, indicates that H2S directly activates the PI3K/AKT pathway and that activation of this pathway is hierarchically higher in the mechanism that leads to MOR activation by H2S.
Phosphorylation (phosphorylation) of PI3K associated with opioid receptor
6) Confidence 0.30 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.36
This suggest a hierarchic order in the observed effects with H2S acting as a KATP channels opener leading to activation of PI3K/AKT pathway and MOR activation and phosphorylation (Figure 10).
Phosphorylation (phosphorylation) of PI3K associated with opioid receptor
7) Confidence 0.30 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.73
Induction of AIA induced upregulation in the expression level of various key signaling proteins such as PI3K, PKB/Akt (total and phosphorylated) and TNF-?
Phosphorylation (phosphorylated) of PI3K associated with arthritis
8) Confidence 0.25 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 0.26 Pain Relevance 0.16
One study examined the hypothesis that phosphorylation of Janus kinase 2 (Jak2) upstream of PI3K is impaired in diabetic hearts by an AT1 receptor-mediated mechanism.
Phosphorylation (phosphorylation) of PI3K in hearts associated with diabetes mellitus
9) Confidence 0.25 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.14 Pain Relevance 0
This impaired glucose transportation was also due to signaling defects that included an attenuated p85 regulatory subunit of phosphatidylinositol 3-kinase (PI3-kinase) and Akt serine phosphorylation.
Phosphorylation (phosphorylation) of PI3-kinase
10) Confidence 0.23 Published 2004 Journal Horm. Metab. Res. Section Abstract Doc Link 15326568 Disease Relevance 0.38 Pain Relevance 0.18
This impaired glucose transportation was also due to signaling defects that included an attenuated p85 regulatory subunit of phosphatidylinositol 3-kinase (PI3-kinase) and Akt serine phosphorylation.
Phosphorylation (phosphorylation) of phosphatidylinositol 3-kinase
11) Confidence 0.23 Published 2004 Journal Horm. Metab. Res. Section Abstract Doc Link 15326568 Disease Relevance 0.44 Pain Relevance 0.19
Apart from IR protein levels, infusion of beta-endorphin reversed the decrease in protein expression for the IRS-1, p85 regulatory subunit of PI3-kinase, and Akt serine phosphorylation in soleus muscle in fructose-fed rats.
Phosphorylation (phosphorylation) of PI3-kinase in soleus
12) Confidence 0.10 Published 2004 Journal Horm. Metab. Res. Section Abstract Doc Link 15326568 Disease Relevance 0.37 Pain Relevance 0.15

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