INT116646

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.39
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b) response to stress (Gsk3b)
cytoplasm (Gsk3b) cytosol (Gsk3b) nucleolus (Gsk3b)
Anatomy Link Frequency
pore 2
Gsk3b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 9 100.00 Very High Very High Very High
Opioid 3 93.60 High High
ischemia 6 91.68 High High
MU agonist 2 70.96 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 5 91.68 High High
Reperfusion Injury 1 91.32 High High
Coronary Artery Disease 1 71.76 Quite High
Hypoxia 2 47.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cardioprotective effect of morphine and a blocker of glycogen synthase kinase 3 beta, SB216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione], via inhibition of the mitochondrial permeability transition pore.
Regulation (effect) of Negative_regulation (blocker) of glycogen synthase kinase 3 beta in pore associated with morphine
1) Confidence 0.44 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 18434587 Disease Relevance 0.33 Pain Relevance 0.54
Glycogen synthase kinase (GSK) inhibition produced by ischemic preconditioning has been previously shown to be regulated through phosphatidylinositol-3 kinase (PI3K).
Regulation (regulated) of Negative_regulation (inhibition) of Glycogen synthase kinase
2) Confidence 0.33 Published 2004 Journal Circ. Res. Section Abstract Doc Link 14976126 Disease Relevance 0.06 Pain Relevance 0.45

General Comments

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