INT116654

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Context Info
Confidence 0.11
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.90
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Eras) plasma membrane (Eras) GTPase activity (Eras)
cellular_component (Eras) biological_process (Eras)
Anatomy Link Frequency
platelets 1
Eras (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 7 92.28 High High
cva 1 81.16 Quite High
cINOD 1 75.12 Quite High
antagonist 15 24.00 Low Low
agonist 15 5.00 Very Low Very Low Very Low
fibrosis 9 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
dorsal root ganglion 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 1 97.32 Very High Very High Very High
Age-related Macular Degeneration 1 90.96 High High
Thrombosis 4 87.32 High High
Colon Cancer 4 84.52 Quite High
Cancer 25 82.96 Quite High
Cv General 3 Under Development 1 81.16 Quite High
Targeted Disruption 15 74.88 Quite High
INFLAMMATION 3 74.88 Quite High
Embryonic Lethality 4 74.24 Quite High
Aging 2 13.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The small GTPase Rac1 is highly induced and this was confirmed by immunoblotting.
Positive_regulation (induced) of small GTPase
1) Confidence 0.11 Published 2004 Journal Carcinogenesis Section Abstract Doc Link 14976132 Disease Relevance 0.49 Pain Relevance 0.31
Nanomolar concentrations of LPA and minimally oxidized LDL induce shape change of washed platelets through LPA receptor-linked signal transduction pathways that presumably involve the activation of the heterotrimeric G12/G13 protein, the small GTPase Rho and Rho kinase, the Rho kinase-mediated inhibition of myosin light-chain phosphatase, and stimulation of myosin light-chain phosphorylation (Bauer et al., 1999; Retzer and Essler, 2000; Retzer et al., 2000).
Positive_regulation (activation) of small GTPase in platelets
2) Confidence 0.01 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.41 Pain Relevance 0.04

General Comments

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