INT116659

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.86
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pick1) Golgi apparatus (Pick1) enzyme binding (Pick1)
protein complex (Pick1) cytoplasm (Pick1) protein targeting (Pick1)
Anatomy Link Frequency
sensory neurons 1
Pick1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
GABAergic 78 95.64 Very High Very High Very High
Pain 3 95.08 Very High Very High Very High
dorsal root ganglion 1 91.20 High High
Kinase C 5 89.40 High High
Neurotransmitter 4 89.04 High High
Pyramidal cell 2 84.88 Quite High
Serotonin 1 84.64 Quite High
ASIC 1 77.28 Quite High
Hippocampus 6 73.80 Quite High
addiction 1 67.84 Quite High
Disease Link Frequency Relevance Heat
Toxicity 2 99.00 Very High Very High Very High
Pain 3 95.08 Very High Very High Very High
Ganglion Cysts 5 90.72 High High
Schizophrenia 1 87.84 High High
Cancer 1 87.24 High High
Disease 1 86.64 High High
Cognitive Disorder 6 71.32 Quite High
Vibrio Infection 2 17.36 Low Low
Repression 2 5.00 Very Low Very Low Very Low
Phototoxic Dermatitis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Zn2+-binding properties of PICK1 are not appreciably affected after the removal of BARC domain (involving BAR domain and C-terminal acidic region).
Neg (not) Regulation (affected) of PICK1
1) Confidence 0.41 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18429931 Disease Relevance 0.35 Pain Relevance 0.09
7-nAChR cell-surface distribution is regulated by interaction with PICK1 [20].
Regulation (regulated) of PICK1
2) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2901346 Disease Relevance 0.14 Pain Relevance 0.28
Long-term overexpression of PICK1 (or the inactive PDZ-domain mutant) was attempted but resulted in toxicity; SPT analysis after 24 h revealed no significant effect of PICK1 on ?
Neg (no) Regulation (effect) of PICK1 associated with toxicity
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2901346 Disease Relevance 0.10 Pain Relevance 0.10
ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1.
Regulation (regulation) of PICK-1 in sensory neurons
4) Confidence 0.03 Published 2004 Journal J. Biol. Chem. Section Title Doc Link 14976185 Disease Relevance 0.27 Pain Relevance 0.54

General Comments

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