INT116677

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 0.65
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ADRBK1) signal transduction (ADRBK1) aging (ADRBK1)
plasma membrane (ADRBK1) cytoplasm (ADRBK1)
ADRBK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 184 94.32 High High
Dismenorea 3 81.20 Quite High
Catecholamine 34 71.72 Quite High
antagonist 42 20.76 Low Low
Kinase C 36 5.00 Very Low Very Low Very Low
Inflammation 22 5.00 Very Low Very Low Very Low
bradykinin 20 5.00 Very Low Very Low Very Low
cytokine 16 5.00 Very Low Very Low Very Low
adenocard 16 5.00 Very Low Very Low Very Low
Potency 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 20 84.00 Quite High
Asthma 86 82.68 Quite High
Dysmenorrhea 3 81.20 Quite High
Neuroblastoma 32 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 18 5.00 Very Low Very Low Very Low
Aids-related Complex 12 5.00 Very Low Very Low Very Low
Hypertension 4 5.00 Very Low Very Low Very Low
Sleep Disorders 4 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GRK2/receptor interactions started within 4 sec, peaked at 10 sec, and decreased to less than 40% within 8 min.
GRK2 Binding (interactions) of
1) Confidence 0.44 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 14976224 Disease Relevance 0.08 Pain Relevance 0.17
Physical GRK2/OTR association was further demonstrated by coimmunoprecipitation of endogenous GRK2 with activated OTR.
GRK2 Binding (association) of
2) Confidence 0.44 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 14976224 Disease Relevance 0.07 Pain Relevance 0.15
These data characterize the temporal and causal relationship of GRK-2/OTR and beta-arrestin/OTR interactions and establish GRK/OTR interaction as a prerequisite for beta-arrestin-mediated OTR desensitization.
GRK-2 Binding (interactions) of
3) Confidence 0.34 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 14976224 Disease Relevance 0 Pain Relevance 0.03
GRK2 and GRK3 are cytosolic proteins that anchor to the membrane via interaction with free G??
GRK2 Binding (interaction) of
4) Confidence 0.18 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0.04
subunit of the G proteins to anchor to the membrane but GRK2 and GRK3 exhibit distinct binding preferences for individual ?
GRK2 Binding (exhibit) of
5) Confidence 0.18 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0
3 isoform preferentially binds GRK3 but not GRK2, whereas ?
GRK2 Binding (binds) of
6) Confidence 0.18 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0
2 bind equally to both GRK3 and GRK2 [35,36].


GRK2 Binding (bind) of
7) Confidence 0.18 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0
Interestingly, GRK2 has been recently shown to contain an RGS domain that can interact specifically with G?
GRK2 Binding (interact) of
8) Confidence 0.08 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.25 Pain Relevance 0.06
Interestingly, GRK2 has been recently shown to contain an RGS domain that can interact specifically with G?
GRK2 Binding (shown) of
9) Confidence 0.08 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.25 Pain Relevance 0.06

General Comments

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