INT11668

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Context Info
Confidence 0.58
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.57
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1f) signal transducer activity (Htr1f)
Anatomy Link Frequency
nerve 1
neurons 1
Htr1f (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 10 100.00 Very High Very High Very High
Periaqueductal grey 55 98.50 Very High Very High Very High
Dorsal horn 4 96.44 Very High Very High Very High
Spinal cord 3 95.40 Very High Very High Very High
Rostral ventromedial medulla 3 94.64 High High
analgesia 3 90.76 High High
medulla 1 90.72 High High
Opioid 10 90.04 High High
Analgesic 8 89.16 High High
Pain 9 88.00 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 55 98.50 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

6 96.00 Very High Very High Very High
Pain 9 88.00 High High
Stress 1 87.64 High High
Headache 10 80.44 Quite High
Functional Bowel Disorder 2 75.00 Quite High
Diarrhoea 2 75.00 Quite High
Epilepsy 1 34.04 Quite Low
Vomiting 2 32.32 Quite Low
Photophobia 1 30.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PAG contains a dense plexus of serotonergic nerve terminals [20], and varying levels of 5-HT1A, 5-HT1B, 5-HT1D and 5-HT1F receptor mRNA and protein has been found in different species [21-25].
Gene_expression (levels) of 5-HT1F in nerve associated with periaqueductal grey
1) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.83 Pain Relevance 1.40
Serotonin1 and serotonin2 receptors hyperpolarize and depolarize separate populations of medial pontine reticular formation neurons in vitro.
Gene_expression (hyperpolarize) of Serotonin1 in neurons
2) Confidence 0.03 Published 1992 Journal Neuroscience Section Title Doc Link 1584409 Disease Relevance 0 Pain Relevance 0.37
This is the first example indicating micro RNA-related expression regulation of a serotonin receptor gene with a cis-regulatory variant affecting this regulation and appearing to be associated with female IBS-D.
Gene_expression (expression) of serotonin receptor gene associated with serotonin
3) Confidence 0.02 Published 2008 Journal Hum. Mol. Genet. Section Abstract Doc Link 18614545 Disease Relevance 0.27 Pain Relevance 0.25

General Comments

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