INT11669

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 6.78
Pain Relevance 10.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Htr2a) cell death (Htr2a) aging (Htr2a)
plasma membrane (Htr2a) response to stress (Htr2a) cytoplasm (Htr2a)
Anatomy Link Frequency
neurons 4
brain 2
sensory neurons 1
spinal cord 1
dorsal horn 1
Htr2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 29 100.00 Very High Very High Very High
dorsal root ganglion 22 100.00 Very High Very High Very High
antagonist 12 100.00 Very High Very High Very High
nociceptor 4 99.92 Very High Very High Very High
Analgesic 14 99.64 Very High Very High Very High
Serotonin 37 99.48 Very High Very High Very High
Raphe magnus 6 99.28 Very High Very High Very High
tramadol 24 99.24 Very High Very High Very High
analgesia 4 99.24 Very High Very High Very High
Inflammation 13 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 33 100.00 Very High Very High Very High
Ganglion Cysts 22 100.00 Very High Very High Very High
Nociception 2 99.84 Very High Very High Very High
Convulsion 7 99.72 Very High Very High Very High
Urological Neuroanatomy 6 99.48 Very High Very High Very High
INFLAMMATION 13 99.18 Very High Very High Very High
Injury 4 98.56 Very High Very High Very High
Hyperalgesia 12 98.04 Very High Very High Very High
Pain 36 97.36 Very High Very High Very High
Arthritis 10 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we characterized neurons expressing 5-HT2A receptors in the rat DRG neurons by means of in situ hybridization, immunohistochemistry, reverse transcription-polymerase chain reaction (RT-PCR) and behavioral tests.
Gene_expression (expressing) of 5-HT2A in neurons associated with dorsal root ganglion
1) Confidence 0.75 Published 2002 Journal Pain Section Abstract Doc Link 12237191 Disease Relevance 0.67 Pain Relevance 0.48
These findings suggest that 5-HT2A receptors are mainly expressed in CGRP-synthesizing small DRG neurons and may be involved in the potentiation of inflammatory pain in the periphery.
Gene_expression (expressed) of 5-HT2A in DRG associated with dorsal root ganglion and eae
2) Confidence 0.75 Published 2002 Journal Pain Section Abstract Doc Link 12237191 Disease Relevance 0.99 Pain Relevance 0.76
Among the 812 differentially expressed candidates, several genes (Adcy5, Htr2a) and pathways (Map kinases, G-proteins, integrins) have already been described as modulated in the brain of morphine-treated rats.
Gene_expression (expressed) of Htr2a in brain associated with morphine
3) Confidence 0.67 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18801381 Disease Relevance 0.07 Pain Relevance 0.80
This study was undertaken to investigate the effect of chronic treatment with fluoxetine, a selective serotonin uptake inhibitor used widely in the treatment of depression, on the distribution and density of 5-HT uptake sites, 5-HT2 receptors, and vesicular amine uptake sites in rat brain.
Gene_expression (distribution) of 5-HT2 in brain associated with depression, serotonin and fluoxetine
4) Confidence 0.65 Published 1993 Journal Synapse Section Abstract Doc Link 8248854 Disease Relevance 0.10 Pain Relevance 0.43
Expression of the 5-HT2A receptor mRNA in NRM, ipsilateral vlPAG, and the ipsilateral spinal dorsal horn of arthritic rats was significantly increased after tramadol treatment.
Gene_expression (Expression) of 5-HT2A in spinal associated with tramadol, raphe magnus, spinal dorsal horn and arthritis
5) Confidence 0.65 Published 2008 Journal Brain Res. Section Abstract Doc Link 18417104 Disease Relevance 0.60 Pain Relevance 2.07
The expression of the 5-HT2A receptor mRNA in the nucleus of raphe magnus (NRM), ventrolateral periaqueductal gray (vlPAG) and spinal dorsal horn of mono-arthritic rats after a ten-day treatment with tramadol was measured with in situ hybridization.
Gene_expression (expression) of 5-HT2A in dorsal horn associated with tramadol, raphe magnus, spinal dorsal horn, central grey and arthritis
6) Confidence 0.65 Published 2008 Journal Brain Res. Section Abstract Doc Link 18417104 Disease Relevance 0.50 Pain Relevance 1.66
Using in vivo microdialysis methods in rats, the nonselective 5-HT2 receptor antagonist ketanserin was observed to produce a robust augmentation of citalopram-, fluoxetine-, and sertraline-induced elevations of hippocampal extracellular serotonin levels.
Gene_expression (produce) of 5-HT2 associated with antagonist, serotonin and fluoxetine
7) Confidence 0.65 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15138437 Disease Relevance 0.09 Pain Relevance 0.78
Four days of complete Freund's adjuvant-induced inflammation of the hindpaw doubled the incidence of 5-HT2A receptor mRNA-expressing neurons to 19.3 +/- 2.8%.
Gene_expression (mRNA-expressing) of 5-HT2A in neurons associated with inflammation
8) Confidence 0.65 Published 2002 Journal Pain Section Abstract Doc Link 12237191 Disease Relevance 0.97 Pain Relevance 0.79
Thus the 5-HT1 and 5-HT2 receptors appear to occupy the G protein receptor sub-family which may be coupled either to adenylate cyclase (most 5-HT1 sub-types) or phosphatidyl inositol (5-HT2 sub-types).
Gene_expression (appear) of 5-HT2
9) Confidence 0.65 Published 1992 Journal Int Clin Psychopharmacol Section Abstract Doc Link 1624753 Disease Relevance 0 Pain Relevance 0.32
Chronic fluoxetine or desmethylimipramine treatment alters 5-HT2 receptor mediated c-fos gene expression.
Gene_expression (expression) of 5-HT2 associated with fluoxetine
10) Confidence 0.65 Published 1995 Journal Eur. J. Pharmacol. Section Title Doc Link 7589222 Disease Relevance 0.08 Pain Relevance 0.45
One of the major serotonin (5-HT) receptor subtypes expressed in the rat dorsal root ganglion (DRG) neurons is the 5-HT2A receptor.
Gene_expression (expressed) of 5-HT2A in neurons associated with ganglion cysts, dorsal root ganglion and serotonin
11) Confidence 0.65 Published 2002 Journal Pain Section Abstract Doc Link 12237191 Disease Relevance 0.54 Pain Relevance 0.41
The expression of SP, NK-1 R, COX-1, 5-HT 1 AR and 5-HT2 AR in the spinal cord (C1-C4) tissue were detected with immunohistochemistry.
Gene_expression (expression) of 5-HT2 in spinal cord
12) Confidence 0.58 Published 2010 Journal Zhen Ci Yan Jiu Section Body Doc Link 20626139 Disease Relevance 0.16 Pain Relevance 0
The 5-HT2A receptor is mainly expressed in nociceptive sensory neurons in rat lumbar dorsal root ganglia.
Gene_expression (expressed) of 5-HT2A in sensory neurons associated with nociception and nociceptor
13) Confidence 0.58 Published 2009 Journal Neuroscience Section Title Doc Link 19362128 Disease Relevance 0.50 Pain Relevance 0.68
In HTR2A, 10 SNPs spanning 5?
Gene_expression (spanning) of HTR2A
14) Confidence 0.43 Published 2010 Journal Journal of Psychosomatic Research Section Body Doc Link PMC2877873 Disease Relevance 0.25 Pain Relevance 0.16
5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.
Gene_expression (depression) of HTR2A associated with depression
15) Confidence 0.18 Published 2009 Journal Neuroreport Section Title Doc Link 19590397 Disease Relevance 0.43 Pain Relevance 0.34
Chronic electroconvulsive seizures increase the expression of serotonin2 receptor mRNA in rat frontal cortex.
Gene_expression (expression) of serotonin2 receptor in frontal cortex associated with convulsion and urological neuroanatomy
16) Confidence 0.10 Published 1993 Journal J. Neurochem. Section Title Doc Link 8376984 Disease Relevance 0.84 Pain Relevance 0.25
Serotonin1 and serotonin2 receptors hyperpolarize and depolarize separate populations of medial pontine reticular formation neurons in vitro.
Gene_expression (hyperpolarize) of serotonin2 in neurons
17) Confidence 0.09 Published 1992 Journal Neuroscience Section Title Doc Link 1584409 Disease Relevance 0 Pain Relevance 0.37

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