INT1167

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Context Info
Confidence 0.53
First Reported 1975
Last Reported 2009
Negated 3
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.86
Pain Relevance 3.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Mastl) cytoskeleton (Mastl) nucleus (Mastl)
cell cycle (Mastl) cell division (Mastl) kinase activity (Mastl)
Anatomy Link Frequency
ileum 1
Mastl (Mus musculus)
Pain Link Frequency Relevance Heat
Delta-9-tetrahydrocannabinol 12 100.00 Very High Very High Very High
antinociception 17 99.40 Very High Very High Very High
adenocard 5 99.16 Very High Very High Very High
gABA 6 98.64 Very High Very High Very High
antagonist 4 98.36 Very High Very High Very High
opioid receptor 6 98.14 Very High Very High Very High
narcan 3 97.52 Very High Very High Very High
agonist 61 97.12 Very High Very High Very High
Physical dependence 2 97.08 Very High Very High Very High
tolerance 51 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Vibrio Infection 2 98.46 Very High Very High Very High
Catalepsy 2 97.12 Very High Very High Very High
Drug Dependence 2 97.08 Very High Very High Very High
Aggression 3 95.60 Very High Very High Very High
Sleep Disorders 3 94.60 High High
Hypothermia 2 93.76 High High
Bordatella Infection 6 93.68 High High
Catatonia 3 93.52 High High
Convulsion 1 85.80 High High
Targeted Disruption 3 79.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the one peripheral test used, CBN did not alter the delta9-THC effect.
Neg (not) Regulation (alter) of delta9-THC
1) Confidence 0.53 Published 1975 Journal Psychopharmacologia Section Abstract Doc Link 168604 Disease Relevance 0.26 Pain Relevance 0.09
CBN, although in general less active, mimicked the effects of delta9-THC in several pharmacological tests: corneal arreflexia in rabbits; climbing rope, open-field, irritability and aggressiveness after REM sleep deprivation in rats; catatonia, analgesia and sleeping time in mice.
Regulation (effects) of delta9-THC associated with catatonia, aggression, sleep disorders and analgesia
2) Confidence 0.34 Published 1975 Journal Psychopharmacologia Section Abstract Doc Link 168604 Disease Relevance 0.28 Pain Relevance 0.09
CBN, although in general less active, mimicked the effects of delta9-THC in several pharmacological tests: corneal arreflexia in rabbits; climbing rope, open-field, irritability and aggressiveness after REM sleep deprivation in rats; catatonia, analgesia and sleeping time in mice.
Regulation (effects) of delta9-THC associated with catatonia, aggression, sleep disorders and analgesia
3) Confidence 0.34 Published 1975 Journal Psychopharmacologia Section Abstract Doc Link 168604 Disease Relevance 0.28 Pain Relevance 0.09
In vitro experiments with guinea pig ileum showed that the ability of THC to inhibit electrically evoked contractions was unaffected by delta-amino-n-valeric acid, a GABA(B) receptor antagonist, and that preparations rendered tolerant to GABA responded normally to THC.
Neg (unaffected) Regulation (unaffected) of THC in ileum associated with gaba, antagonist and delta-9-tetrahydrocannabinol
4) Confidence 0.15 Published 1991 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1666920 Disease Relevance 0.26 Pain Relevance 0.89
For this purpose, we first investigated acute THC responses in mice lacking A2A adenosine receptors.
Spec (investigated) Regulation (responses) of THC associated with adenocard
5) Confidence 0.12 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15450100 Disease Relevance 0.42 Pain Relevance 0.67
In contrast, pretreatment (24 h, i.c.v.) with cholera toxin (0.1-3.0 mg) reduced the antinociception of WIN 55,212-2, had minimal effect on delta9-THC, and dose-dependently increased the antinociception of anandamide (ED50 = 0.50 nmol).
Regulation (effect) of delta9-THC associated with antinociception and vibrio infection
6) Confidence 0.06 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10218903 Disease Relevance 0.26 Pain Relevance 0.68
On the other hand, co-incubation with naloxone (1 microM), an opioid receptor antagonist, did not significantly modify the effect of WIN55,212-2 and completely failed to modify the effect of triangle up(9)-THC on synaptosomal Na(+),K(+)-ATPase.
Neg (failed) Regulation (modify) of THC associated with antagonist, narcan and opioid receptor
7) Confidence 0.05 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17644088 Disease Relevance 0.09 Pain Relevance 0.37
This reduction was only moderated for THC and ACEA (Fig. 5C).
Regulation (moderated) of THC
8) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 0.88

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