INT116703

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Context Info
Confidence 0.18
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.81
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gpx1) mitochondrion (Gpx1) oxidoreductase activity (Gpx1)
nucleus (Gpx1) lipid metabolic process (Gpx1) cytoplasm (Gpx1)
Anatomy Link Frequency
hepatocyte 2
brain 2
Gpx1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 2 98.84 Very High Very High Very High
Glutamate 1 98.48 Very High Very High Very High
Paracetamol 5 67.52 Quite High
anesthesia 2 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 83 99.20 Very High Very High Very High
Cv Unclassified Under Development 1 98.84 Very High Very High Very High
Hepatotoxicity 1 65.20 Quite High
Infection 1 63.04 Quite High
Poisoning 1 59.60 Quite High
Nephrotoxicity 15 42.96 Quite Low
Necrosis 5 39.08 Quite Low
Disorders Of Creatine Metabolism 6 30.60 Quite Low
Disease 14 26.48 Quite Low
Body Weight 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glutamate-cysteine ligase catalytic subunit (GCLC), glutathione S-transferasemu, and glutathione peroxidase 1 were down-regulated in the liver of hepatocyte RXRalpha-deficient mice.
Negative_regulation (-) of Negative_regulation (regulated) of glutathione peroxidase 1 in hepatocyte associated with glutamate
1) Confidence 0.18 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 14978233 Disease Relevance 0.14 Pain Relevance 0.23
The modulation of physiological antioxidant systems by TCM is thought to be a more probable mechanism for the preventative ability of SMS on stressor-mediated oxidative stress, since we previously reported that SMS prevented the loss of GPX activity in the brain after ischemia reperfusion in rats (18–23) in addition to its strong radical scavenging activity.
Negative_regulation (prevented) of Negative_regulation (loss) of GPX in brain associated with stress and ischemia
2) Confidence 0.17 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1876613 Disease Relevance 0.61 Pain Relevance 0.05
SAMC treatment attenuated but not prevented significantly the decrease in GPx activity in the GM+SAMC group.
Negative_regulation (prevented) of Negative_regulation (decrease) of GPx
3) Confidence 0.05 Published 2004 Journal BMC Clin Pharmacol Section Body Doc Link PMC419708 Disease Relevance 0.06 Pain Relevance 0

General Comments

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