INT116705

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2004
Last Reported 2009
Negated 2
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 9.44
Pain Relevance 9.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx2)
Anatomy Link Frequency
ventral root 4
spinal cord 4
spinal 2
paw 2
carotid body 2
P2rx2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 50 100.00 Very High Very High Very High
Dorsal horn 28 100.00 Very High Very High Very High
nMDA receptor 9 100.00 Very High Very High Very High
ischemia 4 99.98 Very High Very High Very High
allodynia 37 99.90 Very High Very High Very High
Lasting pain 16 99.86 Very High Very High Very High
Brush evoked pain 25 99.80 Very High Very High Very High
qutenza 33 98.32 Very High Very High Very High
GABAergic 4 98.32 Very High Very High Very High
antagonist 46 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 2 99.98 Very High Very High Very High
Cv General 2 Under Development 33 99.92 Very High Very High Very High
Neuropathic Pain 114 99.90 Very High Very High Very High
Pain 57 99.86 Very High Very High Very High
Hypoxia 60 99.54 Very High Very High Very High
Nociception 42 99.48 Very High Very High Very High
Immunization 1 99.20 Very High Very High Very High
Injury 6 99.08 Very High Very High Very High
Nervous System Injury 48 98.84 Very High Very High Very High
INFLAMMATION 51 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The long-lasting allodynia was induced by activation of spinal P2X 2/3-receptors, and the induction and early phase of maintenance, but not the late phase, was mediated, at least in part, by the activation of spinal glial cells.
Positive_regulation (induced) of Positive_regulation (activation) of P2X 2 in spinal associated with allodynia
1) Confidence 0.49 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18520049 Disease Relevance 0.44 Pain Relevance 0.53
It was hypothesized that hypoxic chemotranduction with stabilization of HIF-1 and activation of P2X/P2Y purinoceptors stimulate the endogenous NO production in the rat carotid body.
Positive_regulation (stabilization) of Positive_regulation (activation) of P2X in carotid body associated with hypoxia
2) Confidence 0.39 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.49 Pain Relevance 0
The level of activated ERK is markedly enhanced by mechanical stimulation given to the inflamed hind paw, and, interestingly, the enhancement requires the activation of P2X receptors, presumably by endogenous ATP at the periphery.
Positive_regulation (requires) of Positive_regulation (activation) of P2X in paw
3) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 0.70 Pain Relevance 0.45
The results revealed that the myocardial ischemia induced the upregulation of P2X(3) receptor in function and morphous and P2X(3) receptor antagonist A-317491 inhibited P2X agonist activated currents and P2X(3) mRNA expression.
Positive_regulation (induced) of Positive_regulation (upregulation) of P2X associated with coronary artery disease, antagonist, ischemia and agonist
4) Confidence 0.25 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18158099 Disease Relevance 1.05 Pain Relevance 0.70
Accumulation of P2X(4)R(+) cells in the lumbar dorsal horn was observed at day 9, reached the maximal level at day 17 and remained elevated until day 37 after immunization.
Positive_regulation (elevated) of Positive_regulation (Accumulation) of P2X in dorsal horn associated with immunization and dorsal horn
5) Confidence 0.17 Published 2008 Journal Neuroscience Section Abstract Doc Link 18276080 Disease Relevance 1.74 Pain Relevance 1.60
It is concluded that Zn(2+) potentiated slow ventral root potential induced by primary afferent stimulation, which was mediated by the activation of N-methyl-D-aspartate receptors but not by activation of P2X receptors or blockade of glycinergic and GABAergic inhibition.
Neg (not) Positive_regulation (activation) of Positive_regulation (activation) of P2X in ventral root associated with gabaergic and nmda receptor
6) Confidence 0.16 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360285 Disease Relevance 0 Pain Relevance 0.69
It is concluded that Zn(2+) potentiated slow ventral root potential induced by primary afferent stimulation, which was mediated by the activation of N-methyl-D-aspartate receptors but not by activation of P2X receptors or blockade of glycinergic and GABAergic inhibition.
Neg (not) Positive_regulation (mediated) of Positive_regulation (activation) of P2X in ventral root associated with gabaergic and nmda receptor
7) Confidence 0.16 Published 2006 Journal Neuroscience Section Abstract Doc Link 16360285 Disease Relevance 0 Pain Relevance 0.70
Activation of P2X3-containing receptors has been suggested to provide a specific mechanism wherein ATP released via synaptic transmission or tissue injury elicits nociception, with potential discrete role for P2X3 and P2X2/3 receptor activation in acute and chronic pain [13].
Positive_regulation (role) of Positive_regulation (activation) of P2X2 associated with nociception, lasting pain and injury
8) Confidence 0.15 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0.74 Pain Relevance 0.47
Activation of different P2X and P2Y receptor subtypes is known to depend upon extracellular concentration of ATP (McLarnon, 2005).
Positive_regulation (depend) of Positive_regulation (Activation) of P2X
9) Confidence 0.09 Published 2007 Journal The Journal of Physiology Section Body Doc Link PMC2375460 Disease Relevance 0.56 Pain Relevance 0.26
Taken together, our results demonstrate that activation of P2X(4) or p38MAPK in spinal cord microglia is necessary for tactile allodynia after nerve injury.
Positive_regulation (necessary) of Positive_regulation (activation) of P2X in microglia associated with brush evoked pain, nervous system injury and spinal cord
10) Confidence 0.08 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14978347 Disease Relevance 1.03 Pain Relevance 1.01
We also found that the expression level of P2X(4) was increased strikingly in spinal cord microgila after nerve injury and that pharmacological blockade or inhibition of the expression of P2X(4) reversed the allodynia.
Positive_regulation (increased) of Positive_regulation (increased) of P2X in spinal cord associated with nervous system injury, allodynia and spinal cord
11) Confidence 0.06 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14978347 Disease Relevance 0.91 Pain Relevance 1.05
We report here that tactile allodynia under the chronic pain state requires an activation of the P2X(4) ionotropic ATP receptor and p38 mitogen-activated protein kinase (MAPK) in spinal cord microglia.
Positive_regulation (requires) of Positive_regulation (activation) of P2X in spinal cord associated with brush evoked pain, lasting pain and spinal cord
12) Confidence 0.05 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14978347 Disease Relevance 0.85 Pain Relevance 0.90
meATP could be due to conduction block following the activation of P2X receptors on primary afferent axons.
Positive_regulation (conduction) of Positive_regulation (activation) of P2X
13) Confidence 0.04 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074354 Disease Relevance 0.22 Pain Relevance 0.80
The latter may in turn promote the release of ATP to activate P2X receptors, resulting in sensitization of capsaicin-sensitive laryngeal afferent fibers and LAH.
Spec (may) Positive_regulation (promote) of Positive_regulation (activate) of P2X associated with asthma and qutenza
14) Confidence 0.03 Published 2009 Journal J. Appl. Physiol. Section Abstract Doc Link 19246655 Disease Relevance 0.72 Pain Relevance 0.32

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox