INT116706

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Context Info
Confidence 0.25
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 8.50
Pain Relevance 7.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Mapk4) cell cycle (Mapk4) cytoplasm (Mapk4)
Anatomy Link Frequency
spinal cord 3
brain 2
dorsal horn 2
microglial cells 2
astrocytes 1
Mapk4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 21 99.84 Very High Very High Very High
Dorsal horn 3 99.42 Very High Very High Very High
Dorsal horn neuron 4 99.36 Very High Very High Very High
intrathecal 4 98.74 Very High Very High Very High
cytokine 11 98.68 Very High Very High Very High
Spontaneous pain 4 98.48 Very High Very High Very High
Brush evoked pain 17 98.06 Very High Very High Very High
cINOD 11 97.76 Very High Very High Very High
Cancer pain 10 96.64 Very High Very High Very High
Hippocampus 66 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 202 99.44 Very High Very High Very High
Cancer 7 99.14 Very High Very High Very High
Injury 10 98.90 Very High Very High Very High
Pain 19 98.48 Very High Very High Very High
Neuropathic Pain 35 98.06 Very High Very High Very High
Cancer Pain 10 96.64 Very High Very High Very High
Disease 23 95.00 High High
Nervous System Injury 11 93.52 High High
INFLAMMATION 29 93.48 High High
Hyperalgesia 2 92.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal application of PPF significantly attenuated the expression of phosphorylated p-38alpha MAPK in superficial dorsal horn neurons (10 mM) and in microglia (1 and 10 mM) in the lumbar spinal cord compared to the hemisection group (p<0.05).
Phosphorylation (phosphorylated) of p-38alpha MAPK in spinal cord associated with dorsal horn neuron, spinal cord and intrathecal
1) Confidence 0.25 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19699199 Disease Relevance 0.34 Pain Relevance 0.80
After T13 spinal hemisection, significantly increased phosphorylated (activated form) p-38alpha MAPK expression was present in both superficial and deep dorsal horn neurons as well as in microglia, but not in astrocytes, in the lumbar spinal cord compared to sham controls (p<0.05).
Phosphorylation (phosphorylated) of p-38alpha MAPK in astrocytes associated with dorsal horn neuron and spinal cord
2) Confidence 0.16 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19699199 Disease Relevance 0.39 Pain Relevance 0.80
In the rats, activated microglia were detected in the injured side of the dorsal horn and the level of the dually-phosphorylated active form of p38MAPK (phospho-p38MAPK) in these microglia was increased.
Phosphorylation (phosphorylated) of p38MAPK in microglia associated with dorsal horn
3) Confidence 0.15 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14978347 Disease Relevance 0.92 Pain Relevance 1.05
These results demonstrate that TLR4-dependent phosphorylation of p38MAPK in spinal cord of rats might contribute to the development and maintenance of bone cancer pain, and p38MAPK and TLR4 would possibly be the potential targets for pain therapy.
Phosphorylation (phosphorylation) of p38MAPK in spinal cord associated with pain, cancer pain and spinal cord
4) Confidence 0.09 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.00 Pain Relevance 0.83
We have demonstrated that tactile allodynia and spontaneous pain of female rats with tibia tumors were correlated with the increase of both phosphorylated-p38MAPK (p-p38MAPK) and proinflammatory cytokines (IL-1beta and TNF-alpha) in the spinal cord 6 days after Walker 256 cells' inoculation.
Phosphorylation (phosphorylated) of p38MAPK in spinal cord associated with pain, brush evoked pain, cancer, spontaneous pain, spinal cord and cytokine
5) Confidence 0.09 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.07 Pain Relevance 0.91
In the rats, activated microglia were detected in the injury side of the dorsal horn where the level of the dually phosphorylated active form of p38MAPK (phospho-p38MAPK) was increased.
Phosphorylation (phosphorylated) of p38MAPK in dorsal horn associated with injury and dorsal horn
6) Confidence 0.08 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469044 Disease Relevance 1.19 Pain Relevance 0.99
In the rats, activated microglia were detected in the injury side of the dorsal horn where the level of the dually phosphorylated active form of p38MAPK (phospho-p38MAPK) was increased.
Phosphorylation (phosphorylated) of p38MAPK in dorsal horn associated with injury and dorsal horn
7) Confidence 0.08 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469044 Disease Relevance 1.18 Pain Relevance 0.98
Consistent with the lack of forced swim on phosphorylation of p38MAPK, there appeared to be no change in levels of its activator, P-MKK3/6.
Phosphorylation (phosphorylation) of p38MAPK
8) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Abstract Doc Link PMC526203 Disease Relevance 0.29 Pain Relevance 0.14
In a previous study we tested this hypothesis and found indeed that acute restraint stress increased P-Erk concentrations in several stress-relevant brain areas; however, neither JNK nor p38MAPK phosphorylation were altered by restraint stress [37].
Phosphorylation (phosphorylation) of p38MAPK in brain associated with stress
9) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.74 Pain Relevance 0.09
In contrast to its effects on the Erk and JNK pathways, swim stress exhibited no effect on the phosphorylation of p38MAPK in any brain region, with the exception of a small but significant increase (55%) in the hippocampus (Figs. 5 and 6).
Phosphorylation (phosphorylation) of p38MAPK in brain associated with stress and hippocampus
10) Confidence 0.01 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC526203 Disease Relevance 0.49 Pain Relevance 0.15
NSAIDs target p38 mitogen-activated protein kinase (MAPK) in addition to their main target COX [23] and inhibition of p38MAPK phosphorylation blocks NO release from activated microglial cells [24].
Phosphorylation (phosphorylation) of p38MAPK in microglial cells associated with cinod
11) Confidence 0.01 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC483059 Disease Relevance 0.90 Pain Relevance 1.05

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