INT116710

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Context Info
Confidence 0.11
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 5.45
Pain Relevance 4.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Mapk4) cell cycle (Mapk4) cytoplasm (Mapk4)
Anatomy Link Frequency
spinal cord 4
dorsal horn 4
microglia 2
Mapk4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 13 99.84 Very High Very High Very High
Dorsal horn 3 99.42 Very High Very High Very High
Spontaneous pain 4 98.82 Very High Very High Very High
cytokine 4 98.68 Very High Very High Very High
Brush evoked pain 17 98.40 Very High Very High Very High
Cancer pain 10 96.64 Very High Very High Very High
allodynia 9 95.36 Very High Very High Very High
Neuropathic pain 3 95.00 High High
Inflammation 2 94.16 High High
Pain 10 93.52 High High
Disease Link Frequency Relevance Heat
Cancer 6 99.48 Very High Very High Very High
Injury 2 98.90 Very High Very High Very High
Pain 19 98.82 Very High Very High Very High
Neuropathic Pain 29 98.40 Very High Very High Very High
Cancer Pain 10 96.64 Very High Very High Very High
INFLAMMATION 2 94.16 High High
Nervous System Injury 11 93.52 High High
Hyperalgesia 2 92.72 High High
Hypersensitivity 2 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the rats, activated microglia were detected in the injured side of the dorsal horn and the level of the dually-phosphorylated active form of p38MAPK (phospho-p38MAPK) in these microglia was increased.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of p38MAPK in microglia associated with dorsal horn
1) Confidence 0.11 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14978347 Disease Relevance 0.93 Pain Relevance 1.07
In the rats, activated microglia were detected in the injury side of the dorsal horn where the level of the dually phosphorylated active form of p38MAPK (phospho-p38MAPK) was increased.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of p38MAPK in dorsal horn associated with injury and dorsal horn
2) Confidence 0.07 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469044 Disease Relevance 1.19 Pain Relevance 0.99
These results demonstrate that TLR4-dependent phosphorylation of p38MAPK in spinal cord of rats might contribute to the development and maintenance of bone cancer pain, and p38MAPK and TLR4 would possibly be the potential targets for pain therapy.
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of p38MAPK in spinal cord associated with pain, cancer pain and spinal cord
3) Confidence 0.06 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.05 Pain Relevance 0.88
We have demonstrated that tactile allodynia and spontaneous pain of female rats with tibia tumors were correlated with the increase of both phosphorylated-p38MAPK (p-p38MAPK) and proinflammatory cytokines (IL-1beta and TNF-alpha) in the spinal cord 6 days after Walker 256 cells' inoculation.
Positive_regulation (increase) of Phosphorylation (phosphorylated) of p38MAPK in spinal cord associated with pain, brush evoked pain, cancer, spontaneous pain, spinal cord and cytokine
4) Confidence 0.06 Published 2010 Journal Brain Res. Section Abstract Doc Link 20478276 Disease Relevance 1.08 Pain Relevance 0.92
In the rats, activated microglia were detected in the injury side of the dorsal horn where the level of the dually phosphorylated active form of p38MAPK (phospho-p38MAPK) was increased.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of p38MAPK in dorsal horn associated with injury and dorsal horn
5) Confidence 0.05 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469044 Disease Relevance 1.19 Pain Relevance 0.99

General Comments

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