INT116716

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 6.92
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CCR7) intracellular (CCR7) signal transducer activity (CCR7)
Anatomy Link Frequency
lymph nodes 6
CD86 2
PDL-1 2
muscle 2
arm 2
CCR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 8 94.96 High High
Inflammation 38 90.76 High High
Chronic pancreatitis 10 89.68 High High
Intercostal nerve 10 84.40 Quite High
abdominal pain 1 75.36 Quite High
chemokine 33 75.00 Quite High
agonist 24 63.52 Quite High
cytokine 29 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 10 99.84 Very High Very High Very High
Infection 385 99.58 Very High Very High Very High
Adenocarcinoma 90 99.42 Very High Very High Very High
Pleural Effusion 2 98.60 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 168 95.64 Very High Very High Very High
Injury 36 95.56 Very High Very High Very High
INFLAMMATION 46 94.60 High High
Disease Progression 56 90.76 High High
Paralysis 6 89.80 High High
Pancreatitis 10 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results for CCR7 expression of lymphoma cells in the lung and pleural effusion were negative.
Positive_regulation (results) of Gene_expression (expression) of CCR7 in lung associated with pleural effusion and lymphatic system cancer
1) Confidence 0.68 Published 2004 Journal Int. J. Hematol. Section Abstract Doc Link 14979477 Disease Relevance 1.15 Pain Relevance 0.15
We now provide evidence of a functional link between CCL19 upregulation in lymph nodes and increased expression of CCR7 on circulating mDC that promotes mDC recruitment to lymph nodes in progressive SIV infection.
Positive_regulation (increased) of Gene_expression (expression) of CCR7 in lymph nodes associated with infection
2) Confidence 0.34 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.01 Pain Relevance 0.08
Progressive SIV infection was associated with increased CCR7 expression on blood mDC and an 8-fold increase in expression of CCL19 mRNA in lymph nodes, consistent with increased mDC recruitment.
Positive_regulation (increased) of Gene_expression (expression) of CCR7 in lymph nodes associated with infection
3) Confidence 0.34 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC3009592 Disease Relevance 1.33 Pain Relevance 0.06
The increase in CD80 at week 32 suggested mDC were again activated during the period of ART discontinuation, although no increase in CCR7 or CD86 expression was noted at this time (Figure 3A–C).
Neg (no) Positive_regulation (increase) of Gene_expression (expression) of CCR7 in CD86
4) Confidence 0.34 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.69 Pain Relevance 0.04
Therefore, we decided to perform a CC7 transfer to the median nerve, expecting it to serve as the motor source of a free functioning muscle transfer as well as for recovery of the sensation of the hand.
Positive_regulation (transfer) of Gene_expression (transfer) of CC7 in muscle
5) Confidence 0.32 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2080628 Disease Relevance 0.24 Pain Relevance 0.04
We found a partial maturation of the blood MDCs and PDCs in PDAC patients with significantly enhanced expression of CD83, CD40, B7H3, PDL-1, CCR6, and CCR7 and decreased expression of ICOSL, and DCIR.
Positive_regulation (enhanced) of Gene_expression (expression) of CCR7 in PDL-1 associated with adenocarcinoma
6) Confidence 0.31 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955544 Disease Relevance 1.30 Pain Relevance 0.23
As the first step of the reconstruction, the CC7 was transferred to the median nerve through a vascularized ulnar nerve taken from the affected arm.
Positive_regulation (transferred) of Gene_expression (transferred) of CC7 in arm
7) Confidence 0.30 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2080628 Disease Relevance 0.17 Pain Relevance 0
We now provide evidence of a functional link between CCL19 upregulation in lymph nodes and increased expression of CCR7 on circulating mDC that promotes mDC recruitment to lymph nodes in progressive SIV infection.
Positive_regulation (upregulation) of Gene_expression (expression) of CCR7 in lymph nodes associated with infection
8) Confidence 0.25 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.02 Pain Relevance 0.08

General Comments

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