INT116717

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Context Info
Confidence 0.76
First Reported 2004
Last Reported 2010
Negated 3
Speculated 4
Reported most in Body
Documents 37
Total Number 49
Disease Relevance 34.10
Pain Relevance 7.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CCR7) intracellular (CCR7) signal transducer activity (CCR7)
Anatomy Link Frequency
lymph node 10
CD86 4
blood 4
T cells 4
lungs 3
CCR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 910 100.00 Very High Very High Very High
Inflammation 541 100.00 Very High Very High Very High
Intercostal nerve 35 99.52 Very High Very High Very High
rheumatoid arthritis 441 99.48 Very High Very High Very High
endometriosis 70 97.44 Very High Very High Very High
Inflammatory response 30 93.28 High High
abdominal pain 6 93.04 High High
Chronic pancreatitis 80 91.68 High High
Arthritis 102 89.92 High High
Paresthesia 7 89.52 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 592 100.00 Very High Very High Very High
Enteropathy 8 99.92 Very High Very High Very High
Lymphatic System Cancer 42 99.84 Very High Very High Very High
Adenocarcinoma 726 99.48 Very High Very High Very High
Rheumatoid Arthritis 443 99.48 Very High Very High Very High
Infection 1044 99.38 Very High Very High Very High
Pleural Effusion 8 98.60 Very High Very High Very High
Disease 412 98.30 Very High Very High Very High
Cancer 782 98.24 Very High Very High Very High
Metastasis 88 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We present a case of ETCL with involvement of the lungs and kidneys and report CC chemokine receptor 7 (CCR7) expression of lymphoma cells.
Gene_expression (expression) of CCR7 in lungs associated with chemokine and lymphatic system cancer
1) Confidence 0.76 Published 2004 Journal Int. J. Hematol. Section Abstract Doc Link 14979477 Disease Relevance 1.10 Pain Relevance 0.18
The results for CCR7 expression of lymphoma cells in the lung and pleural effusion were negative.
Gene_expression (expression) of CCR7 in lung associated with pleural effusion and lymphatic system cancer
2) Confidence 0.76 Published 2004 Journal Int. J. Hematol. Section Abstract Doc Link 14979477 Disease Relevance 1.15 Pain Relevance 0.15
Extranodal multiple involvement of enteropathy-type T-cell lymphoma without expression of CC chemokine receptor 7.
Gene_expression (expression) of chemokine receptor 7 in T-cell associated with chemokine, lymphatic system cancer and enteropathy
3) Confidence 0.66 Published 2004 Journal Int. J. Hematol. Section Title Doc Link 14979477 Disease Relevance 1.28 Pain Relevance 0.18
We present a case of ETCL with involvement of the lungs and kidneys and report CC chemokine receptor 7 (CCR7) expression of lymphoma cells.
Gene_expression (expression) of chemokine receptor 7 in lungs associated with chemokine and lymphatic system cancer
4) Confidence 0.66 Published 2004 Journal Int. J. Hematol. Section Abstract Doc Link 14979477 Disease Relevance 1.11 Pain Relevance 0.18
The detection of CCR7 and CCR9 in RA was only possible after extended exposure times, but at the time points used for quantification no regulation was demonstrated.
Gene_expression (detection) of CCR7 associated with rheumatoid arthritis
5) Confidence 0.65 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.08 Pain Relevance 0.73
Therefore, we decided to perform a CC7 transfer to the median nerve, expecting it to serve as the motor source of a free functioning muscle transfer as well as for recovery of the sensation of the hand.
Gene_expression (transfer) of CC7 in muscle
6) Confidence 0.49 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2080628 Disease Relevance 0.24 Pain Relevance 0.04
Blood PDCs express many different chemokine receptors including CCR2, CCR5, CCR6, CCR7, CXCR3, and CXCR4 [40], whereas MDC express CCR1, CCR2, CCR3, CCR5, CCR6, CCR7 and CCR8 [19], [20], [21].
Gene_expression (express) of CCR7 in Blood associated with chemokine
7) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.28 Pain Relevance 0.14
We found a partial maturation of the blood MDCs and PDCs in PDAC patients with significantly enhanced expression of CD83, CD40, B7H3, PDL-1, CCR6, and CCR7 and decreased expression of ICOSL, and DCIR.
Gene_expression (expression) of CCR7 in PDL-1 associated with adenocarcinoma
8) Confidence 0.48 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955544 Disease Relevance 1.30 Pain Relevance 0.23
To address the question of B cell migration into the inflamed synovial tissue of patients with rheumatoid arthritis (RA), peripheral blood naive B cells, memory B cells and plasma cells were analyzed for cell surface expression of the chemokine receptors CXCR3, CXCR4, CXCR5, CCR5, CCR6, CCR7 and CCR9.
Spec (analyzed) Gene_expression (expression) of CCR7 in B cell associated with chemokine and rheumatoid arthritis
9) Confidence 0.46 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257429 Disease Relevance 0.89 Pain Relevance 0.43
The memory population may be further divided by the expression or loss of expression of CCR7 [12].
Gene_expression (expression) of CCR7
10) Confidence 0.43 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.07 Pain Relevance 0.17
We analysed expression of CCR7, CD28 and CD45RA on the CD8 cells from the joint, which were producing CCL5.
Spec (analysed) Gene_expression (expression) of CCR7 in joint
11) Confidence 0.43 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.15 Pain Relevance 0.17
Moreover, for this patient no motor source was available without the vascularized nerve connecting CC7.
Gene_expression (connecting) of CC7 in nerve
12) Confidence 0.43 Published 2007 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2080628 Disease Relevance 0.17 Pain Relevance 0.05
CCR6 regulates the migration and recruitment of DCs and T cells during inflammation, whereas CCR7 controls the migration of DCs and T cells to lymphoid organs due to production of CCL19 and CCL21 at these sites [44].
Gene_expression (controls) of CCR7 in T cells associated with inflammation
13) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.04 Pain Relevance 0.19
Significantly increased levels of CCR6 were found on MDCs pre and post surgery (pre: median 380, post: median 398) compared to healthy individuals (median 255) (Figure 5C), and for CCR7 (pre: median 1.6%, post: median 1.6%, control: median 0%) (Figure 5D) but not for CCR2 (Figure 5A).
Neg (not) Gene_expression (found) of CCR7
14) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.17 Pain Relevance 0.12
Using CD45RA with CD27 or CCR7 coexpression to define the naive subsets, rhIL-7 therapy preferentially expanded naive CD4+ and CD8+ T cells, leading to increased frequency (Fig. 5, A and C) and absolute numbers (Fig. 6, A and D).
Gene_expression (coexpression) of CCR7 in T cells
15) Confidence 0.41 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0 Pain Relevance 0
The analysis of chemokine receptor expression showed that the majority of peripheral blood B cells is positive for CXCR3, CXCR4, CXCR5, CCR6 and CCR7.
Gene_expression (positive) of CCR7 in blood associated with chemokine
16) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257429 Disease Relevance 1.02 Pain Relevance 0.54
In contrast to stable infection, mDC in lymph nodes of animals with progressive infection showed essentially no difference in expression of CCR7 and activation markers relative to naïve animals, although the proportion of cells expressing these markers was substantially greater than in blood.
Gene_expression (expression) of CCR7 in blood associated with infection
17) Confidence 0.38 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.91 Pain Relevance 0.03
Progressive SIV infection was associated with increased CCR7 expression on blood mDC and an 8-fold increase in expression of CCL19 mRNA in lymph nodes, consistent with increased mDC recruitment.
Gene_expression (expression) of CCR7 in lymph nodes associated with infection
18) Confidence 0.38 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC3009592 Disease Relevance 1.32 Pain Relevance 0.06
The increase in CD80 at week 32 suggested mDC were again activated during the period of ART discontinuation, although no increase in CCR7 or CD86 expression was noted at this time (Figure 3A–C).
Gene_expression (expression) of CCR7 in CD86
19) Confidence 0.38 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.68 Pain Relevance 0.04
We now provide evidence of a functional link between CCL19 upregulation in lymph nodes and increased expression of CCR7 on circulating mDC that promotes mDC recruitment to lymph nodes in progressive SIV infection.
Gene_expression (expression) of CCR7 in lymph nodes associated with infection
20) Confidence 0.38 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.01 Pain Relevance 0.08

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