INT116725

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 16.33
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (CETP) transport (CETP) extracellular space (CETP)
small molecule metabolic process (CETP) extracellular region (CETP) lipid metabolic process (CETP)
Anatomy Link Frequency
plasma 4
liver 2
coronary artery 1
CETP (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 34 99.44 Very High Very High Very High
Inflammation 101 81.28 Quite High
cva 1 75.00 Quite High
Angina 34 66.16 Quite High
Bile 8 48.48 Quite Low
Potency 2 13.12 Low Low
agonist 30 5.00 Very Low Very Low Very Low
alcohol 29 5.00 Very Low Very Low Very Low
fibrosis 10 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 1687 100.00 Very High Very High Very High
Coronary Heart Disease 77 99.22 Very High Very High Very High
Liver Disease 70 98.72 Very High Very High Very High
Targeted Disruption 54 98.56 Very High Very High Very High
Cancer 12 97.84 Very High Very High Very High
Atherosclerosis 183 97.28 Very High Very High Very High
Coronary Artery Disease 152 96.56 Very High Very High Very High
Cirrhosis 85 88.04 High High
Pressure And Volume Under Development 49 87.56 High High
INFLAMMATION 108 81.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A study of patients with the “B1” variant of the CETP gene showed high levels of baseline CETP activity and low levels of HDL-C with corresponding progression of atherosclerosis.
Positive_regulation (levels) of CETP associated with atherosclerosis and disorder of lipid metabolism
1) Confidence 0.49 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.82 Pain Relevance 0
A nested case control study known as the European Prospective Investigation into Cancer and nutrition (EPIC)-Norfolk cohort study suggested an increased CHD risk in patients with elevated TG and elevated CETP levels (Boekholdt et al 2004).
Positive_regulation (elevated) of CETP associated with cancer and coronary heart disease
2) Confidence 0.43 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.96 Pain Relevance 0
The plasma levels of apoB, apo CIII, Ox-LDL, CETP, hs-CRP and homocysteine were equally increased in both the VSA and CAD groups.
Positive_regulation (increased) of CETP in plasma
3) Confidence 0.43 Published 2003 Journal Nutr Metab Cardiovasc Dis Section Body Doc Link 14979683 Disease Relevance 0.23 Pain Relevance 0
The increases in plasma CETP, Ox-LDL, hs-CRP and homocysteine were equally important markers of VAS and CAD.


Positive_regulation (increases) of CETP in plasma
4) Confidence 0.43 Published 2003 Journal Nutr Metab Cardiovasc Dis Section Body Doc Link 14979683 Disease Relevance 0.18 Pain Relevance 0
The increases in plasma RLP-C, CETP, hs-CRP and homocysteine were not significantly different between stable and unstable states of angina pectoris in either the VSA or CAD group.
Positive_regulation (increases) of CETP in plasma
5) Confidence 0.43 Published 2003 Journal Nutr Metab Cardiovasc Dis Section Body Doc Link 14979683 Disease Relevance 0.21 Pain Relevance 0
High PLTP activity might promote CETP activity, thus decreasing HDL levels in human plasma.
Spec (might) Positive_regulation (promote) of CETP in plasma associated with disorder of lipid metabolism
6) Confidence 0.42 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2793253 Disease Relevance 1.26 Pain Relevance 0.04
Phospholipid transfer protein (PLTP) and cholesterol ester transfer protein (CETP) activity and Hs-CRP concentrations were also elevated in patients.


Positive_regulation (elevated) of cholesterol ester transfer protein
7) Confidence 0.40 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1360085 Disease Relevance 0.75 Pain Relevance 0
Phospholipid transfer protein (PLTP) and cholesterol ester transfer protein (CETP) activity and Hs-CRP concentrations were also elevated in patients.


Positive_regulation (elevated) of CETP
8) Confidence 0.40 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1360085 Disease Relevance 0.74 Pain Relevance 0
The current study presents additional safety data for an agent that targets CETP ahead of the ongoing large phase III dal-OUTCOMES trial.23 In this analysis, dalcetrapib was found not to be associated with any clinically relevant safety concerns with regard to overall or cardiovascular AEs.
Positive_regulation (targets) of CETP
9) Confidence 0.38 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2821630 Disease Relevance 0.61 Pain Relevance 0.03
Dalcetrapib increased HDL-C (33.4%, Week 24; 33.8%, Week 48), decreased CETP activity (–53.5%, Week 24; –56.5%, Week 48), and increased apolipoprotein A-I (11.4%, Week 24; 16.4%, Week 48).
Positive_regulation (increased) of CETP associated with disorder of lipid metabolism
10) Confidence 0.38 Published 2010 Journal European Heart Journal Section Abstract Doc Link PMC2821630 Disease Relevance 0.35 Pain Relevance 0.05
Dalcetrapib increased HDL-C (33.4%, Week 24; 33.8%, Week 48), decreased CETP activity (–53.5%, Week 24; –56.5%, Week 48), and increased apolipoprotein A-I (11.4%, Week 24; 16.4%, Week 48).
Positive_regulation (increased) of CETP associated with disorder of lipid metabolism
11) Confidence 0.38 Published 2010 Journal European Heart Journal Section Abstract Doc Link PMC2821630 Disease Relevance 0.35 Pain Relevance 0.05
A very high concentration of HDL-C with a defect of CETP activity may be a specific biochemical indicator pointing to an increased risk of premature coronary artery disease, and the lipid profile can be improved by use of lipid-lowering drugs.
Positive_regulation (concentration) of CETP in coronary artery associated with coronary artery disease and disorder of lipid metabolism
12) Confidence 0.36 Published 2005 Journal Circ. J. Section Abstract Doc Link 15849450 Disease Relevance 0.50 Pain Relevance 0.10
Many previous studies have indicated that enhanced CETP and HL activities are correlated with various levels of HDL-C[24,25].
Positive_regulation (enhanced) of CETP associated with disorder of lipid metabolism
13) Confidence 0.31 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2920871 Disease Relevance 1.69 Pain Relevance 0
Although PLTP has no CE transfer activity, it can promote CETP activity [25].
Positive_regulation (promote) of CETP
14) Confidence 0.28 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2793253 Disease Relevance 1.46 Pain Relevance 0.03
The concerted action of CETP and HL converts larger HDL2 into smaller HDL3 and releases lipid-free apoA-I and/or pre?
Positive_regulation (action) of CETP
15) Confidence 0.22 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2920871 Disease Relevance 1.38 Pain Relevance 0
The mechanisms leading to increased CETP and PLTP activities in chronic liver disease are also unclear at present.
Positive_regulation (increased) of CETP in liver associated with liver disease
16) Confidence 0.20 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.80 Pain Relevance 0
Although reduced LCAT activity is common in a variety of liver diseases [46], the current report is, to the best of our knowledge, the first to identify increased CETP and PLTP activities as being associated with chronic liver impairment.
Positive_regulation (increased) of CETP in liver associated with liver disease
17) Confidence 0.20 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.74 Pain Relevance 0
An increase in PLTP would lead to larger HDL particles, while an enhancement in CETP and a decrease in LCAT would result in smaller HDL particles with an increase in the HDL3 sub-fraction.
Positive_regulation (enhancement) of CETP associated with disorder of lipid metabolism
18) Confidence 0.18 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.05 Pain Relevance 0.04
The combination of decreased LCAT and increased CETP activities in the patients probably resulted in the increase in small HDL particles.
Positive_regulation (increased) of CETP associated with disorder of lipid metabolism
19) Confidence 0.18 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.91 Pain Relevance 0
Assays were carried out concurrently with measurements of CETP.
Positive_regulation (measurements) of CETP
20) Confidence 0.18 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1262701 Disease Relevance 0.25 Pain Relevance 0

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