INT116728

Context Info Confidence 0.13 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 9.67 Pain Relevance 0.27

Anatomy Link Frequency plasma 1 leukocytes 1 ARSH (Homo sapiens)

Pain Link Frequency Relevance Heat endometriosis 1 96.64 Pain 3 92.16 Central nervous system 10 67.80 addiction 1 66.32 nud 3 60.88 Spinal cord 24 5.00 cva 24 5.00 intrathecal 18 5.00 anesthesia 13 5.00 Antihistamine 6 5.00

Disease Link Frequency Relevance Heat Multiple Sulfatase Deficiency Disease 56 100.00 Disease 221 99.78 Ichthyosis 8 99.74 Mucopolysaccharidosis Ii 17 99.66 Endometriosis 3 99.48 Syndrome 10 98.48 Pruritus 1 98.24 Sialidosis 21 97.92 Gangliosidoses 3 97.88 Mucopolysaccharidoses 446 97.62

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Inhibition of steroid sulfatase activity in endometriotic implants by STX64 (667Coumate): a potential new therapy.

Negative_regulation (Inhibition) of sulfatase associated with endometriosis

1) Confidence 0.13 Published 2008 Journal ScientificWorldJournal Section Title Doc Link 19112542 Disease Relevance 0.38 Pain Relevance 0.14

Absent or low 12S activity in males is diagnostic of Hunter syndrome, provided other sulfatase deficiency has been ruled out.

Negative_regulation (deficiency) of sulfatase associated with mucopolysaccharidosis ii

2) Confidence 0.10 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2890619 Disease Relevance 1.45 Pain Relevance 0

Recessive X-linked ichthyosis is due to a deficiency of cholesterol sulfatase.

Negative_regulation (deficiency) of sulfatase associated with ichthyosis

3) Confidence 0.04 Published 2004 Journal Am J Clin Dermatol Section Abstract Doc Link 14979740 Disease Relevance 0.64 Pain Relevance 0

In either NC or DC group, no prominent peak corresponding to quercetin aglycone appeared in the chromatogram of the extract from rat plasma treated with sulfatase H-5, which possesses both sulfatase activity and glucuronidase activity.

Negative_regulation (possesses) of sulfatase in plasma

4) Confidence 0.03 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127222 Disease Relevance 0.53 Pain Relevance 0

The radiological findings that are characteristic of MPS VI, other MPS, mucolipidoses (ML II I-Cell disease/Leroy, ML III (pseudo-Hurler polydystrophy) and other storage diseases (multiple sulfatase deficiency, carbohydrate-deficient glycoprotein syndrome, GM I gangliosidosis and geleophysic dysplasia) are given the term "dysostosis multiplex".

Negative_regulation (deficiency) of sulfatase associated with gangliosidoses, sialidosis, syndrome, mucopolysaccharidoses, cleidocranial dysplasia, multiple sulfatase deficiency disease and disease

5) Confidence 0.03 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2873242 Disease Relevance 2.15 Pain Relevance 0.03

In addition to multiple sulfatase deficiency, the differential diagnosis should also include other forms of MPS (MPS I, II IVA, VII), sialidosis and mucolipidosis.

Negative_regulation (deficiency) of sulfatase associated with sialidosis, multiple sulfatase deficiency disease and lysosome storage disease

6) Confidence 0.03 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2873242 Disease Relevance 1.24 Pain Relevance 0.03

Diagnosis generally requires evidence of clinical phenotype, arylsulfatase B enzyme activity <10% of the lower limit of normal in cultured fibroblasts or isolated leukocytes, and demonstration of a normal activity of a different sulfatase enzyme (to exclude multiple sulfatase deficiency).

Negative_regulation (deficiency) of sulfatase in leukocytes associated with multiple sulfatase deficiency disease

7) Confidence 0.03 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2873242 Disease Relevance 1.37 Pain Relevance 0.03

Without this modification, sulfatase activity is impaired and the enzymes are therefore unable to degrade lysosomal contents.

Negative_regulation (impaired) of sulfatase

8) Confidence 0.00 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2597715 Disease Relevance 0.86 Pain Relevance 0.03

Without this modification, sulfatase activity is impaired and the enzymes are therefore unable to degrade lysosomal contents.

Negative_regulation (impaired) of sulfatase

9) Confidence 0.00 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 1.05 Pain Relevance 0

General Comments

This test has worked.