INT116736

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 40
Total Number 55
Disease Relevance 31.93
Pain Relevance 15.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) cell proliferation (Mif) extracellular space (Mif)
aging (Mif) extracellular region (Mif) nucleus (Mif)
Anatomy Link Frequency
bladder 17
brain 3
urothelial cells 3
urine 3
lung 2
Mif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX2 5 100.00 Very High Very High Very High
ischemia 602 99.92 Very High Very High Very High
agonist 102 99.70 Very High Very High Very High
Inflammation 929 99.68 Very High Very High Very High
lidocaine 144 99.30 Very High Very High Very High
Spinal cord 164 99.04 Very High Very High Very High
Dorsal horn 72 98.56 Very High Very High Very High
dorsal root ganglion 55 97.72 Very High Very High Very High
cytokine 233 97.12 Very High Very High Very High
Inflammatory stimuli 97 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sepsis 44 100.00 Very High Very High Very High
Pressure And Volume Under Development 34 100.00 Very High Very High Very High
Cv Unclassified Under Development 602 99.92 Very High Very High Very High
Ocular Hypertension 94 99.84 Very High Very High Very High
INFLAMMATION 1009 99.68 Very High Very High Very High
Injury 366 99.44 Very High Very High Very High
Cystitis 248 99.44 Very High Very High Very High
Peptic Ulcer 7 99.20 Very High Very High Very High
Adult Respiratory Distress Syndrome 28 99.12 Very High Very High Very High
Frailty 7 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, neurons in the brain appear to synthesize MIF and quickly release it so that nearby glial cells accumulate MIF protein, without synthesizing it.
Positive_regulation (accumulate) of MIF protein in brain
1) Confidence 0.70 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0 Pain Relevance 0.42
Intravesical LPS induced bladder edema and leukocyte infiltration, as well as increased MIF protein and mRNA in the bladder and lumbosacral spinal cord.
Positive_regulation (induced) of MIF protein in bladder associated with pressure and volume under development and spinal cord
2) Confidence 0.70 Published 2004 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 14980085 Disease Relevance 0.61 Pain Relevance 0.38
Intravesical LPS induced bladder edema and leukocyte infiltration, as well as increased MIF protein and mRNA in the bladder and lumbosacral spinal cord.
Positive_regulation (increased) of MIF protein in bladder associated with pressure and volume under development and spinal cord
3) Confidence 0.70 Published 2004 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 14980085 Disease Relevance 0.60 Pain Relevance 0.38
RESULTS: SP and intravesical capsaicin increased the total amount of MIF in ILF.
Positive_regulation (increased) of MIF
4) Confidence 0.70 Published 2005 Journal J. Urol. Section Body Doc Link 15947686 Disease Relevance 0 Pain Relevance 0
Although SP and capsaicin increased the total amount of MIF detected by enzyme-linked immunosorbent assay in ILF, the patterns of MIF complexes elicited by these 2 treatments were different.
Positive_regulation (increased) of MIF
5) Confidence 0.70 Published 2005 Journal J. Urol. Section Body Doc Link 15947686 Disease Relevance 0 Pain Relevance 0
We cannot rule out a contribution of renal or ureteral MIF release to increased urine MIF levels observed in this study after CYP-treatment, Yet our current findings of increased urine MIF with concomitant decrease in bladder MIF protein levels are consistent with earlier findings where, in animals with bladders isolated from the kidneys (thus removing potential renal and ureteral contributions), we observed similar results [7], [9]).
Positive_regulation (increased) of MIF in urine
6) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.42 Pain Relevance 0.25
We showed that MIF, CD44 and CD74 are all upregulated in the urothelium after experimental inflammation in rats [6], [17].
Positive_regulation (upregulated) of MIF associated with inflammation
7) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.94 Pain Relevance 0.46
In addition, real-time RT-PCR results showed that stimulation with thrombin (100 nM) for 1 hour resulted in an increase in MIF mRNA in UROtsa cells (3.3-fold increase; p0.05; Table 1) when compared to untreated UROtsa cells.


Positive_regulation (increase) of MIF
8) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0
We consider it a likely explanation that direct stimulation of MIF and PAR1 containing cells in the urothelium is involved in thrombin-stimulated MIF release in the rat bladder.
Positive_regulation (stimulation) of MIF in bladder
9) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.55 Pain Relevance 0.53
We investigated the effect of stimulation with thrombin, a Protease Activated Receptor-1 (PAR1) agonist, on MIF release and MIF mRNA upregulation in urothelial cells.


Positive_regulation (upregulation) of MIF in urothelial cells associated with agonist
10) Confidence 0.61 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3013117 Disease Relevance 0.28 Pain Relevance 0.23
Furthermore, intravesical LPS (another commonly used cystitis model in rodents) actually increased total bladder MIF protein and mRNA content [10].
Positive_regulation (increased) of MIF protein in bladder associated with cystitis
11) Confidence 0.61 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.70 Pain Relevance 0.21
In addition, MIF upregulation may represent a neural response to visceral inflammation.
Positive_regulation (upregulation) of MIF in neural associated with inflammation
12) Confidence 0.61 Published 2004 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 14980085 Disease Relevance 0.57 Pain Relevance 0.44
We cannot rule out a contribution of renal or ureteral MIF release to increased urine MIF levels observed in this study after CYP-treatment, Yet our current findings of increased urine MIF with concomitant decrease in bladder MIF protein levels are consistent with earlier findings where, in animals with bladders isolated from the kidneys (thus removing potential renal and ureteral contributions), we observed similar results [7], [9]).
Positive_regulation (increased) of MIF in urine
13) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.42 Pain Relevance 0.25
Our current results suggest that one component of PAR1-mediated bladder inflammation may be release of MIF from urothelial cells and MIF upregulation.
Positive_regulation (upregulation) of MIF in bladder associated with inflammation
14) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 1.21 Pain Relevance 0.71
Media collected from UROtsa cells after thrombin stimulation showed a statistically significant increase in the median amount of MIF at 15 minutes of exposure and reached a maximal effect at 60 minutes of exposure (Fig. 3B).
Positive_regulation (increase) of MIF
15) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0
Bladder/urothelial MIF upregulation during inflammation is a consistent finding regardless of the initiating inflammatory stimulus [6], [8], [39].
Positive_regulation (upregulation) of MIF in Bladder associated with inflammation and inflammatory stimuli
16) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 1.17 Pain Relevance 0.71
MIF ELISA was also tested for its ability to detect serum MIF.
Positive_regulation (tested) of MIF
17) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
MIF mRNA was increased immediately in livers during cold ischemia (data not included).
Positive_regulation (increased) of MIF in livers associated with ischemia
18) Confidence 0.47 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010695 Disease Relevance 1.55 Pain Relevance 0.29
MIF is upregulated in neurons in the brain and released into the CSF following intracisternal LPS or spinal cord injury [7,21].
Positive_regulation (upregulated) of MIF in brain associated with spinal cord
19) Confidence 0.47 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.64 Pain Relevance 0.54
Further examination showed that levels of both MIF and the MIF receptor CD74 were substantially increased within the ipsilateral spinal cord dorsal horn after formalin administration.
Positive_regulation (increased) of MIF in spinal cord dorsal horn associated with dorsal horn and spinal cord
20) Confidence 0.45 Published 2010 Journal Pain Section Abstract Doc Link 20005040 Disease Relevance 0.57 Pain Relevance 0.61

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