INT116737

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Context Info
Confidence 0.81
First Reported 2003
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 63
Total Number 113
Disease Relevance 52.97
Pain Relevance 28.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) cell proliferation (Mif) extracellular space (Mif)
aging (Mif) extracellular region (Mif) nucleus (Mif)
Anatomy Link Frequency
bladder 25
urothelial cells 9
macrophage 6
urine 6
brain 4
Mif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 2229 100.00 Very High Very High Very High
cytokine 542 100.00 Very High Very High Very High
agonist 321 99.90 Very High Very High Very High
Inflammatory stimuli 291 99.84 Very High Very High Very High
substance P 328 99.82 Very High Very High Very High
lidocaine 459 99.78 Very High Very High Very High
qutenza 10 99.78 Very High Very High Very High
ischemia 880 99.48 Very High Very High Very High
referred pain 19 99.48 Very High Very High Very High
Spinal cord 402 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2462 100.00 Very High Very High Very High
Cystitis 514 100.00 Very High Very High Very High
Endotoxemia 57 99.76 Very High Very High Very High
Ovarian Cancer 8 99.76 Very High Very High Very High
Neurogenic Inflammation 74 99.68 Very High Very High Very High
Cv Unclassified Under Development 880 99.48 Very High Very High Very High
Referred Pain 19 99.48 Very High Very High Very High
Stress 352 99.38 Very High Very High Very High
Cancer 338 99.32 Very High Very High Very High
Reprotox - General 1 41 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that MIF released from the bladder sustains or amplifies SP induced inflammation, a possibility that agrees with known MIF proinflammatory functions.
Localization (released) of MIF in bladder
1) Confidence 0.81 Published 2004 Journal J. Urol. Section Body Doc Link 15371880 Disease Relevance 0.12 Pain Relevance 0
Our previous studies reported the anatomical localization for MIF only in the bladder, while the location of MIF in the peripheral ganglia (MPG; DRG) and in the lumbosacral spinal cord was not determined since the focus was on the change in MIF amounts in these tissues following bladder inflammation [10,11].
Localization (localization) of MIF in bladder associated with inflammation and spinal cord
2) Confidence 0.80 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.51 Pain Relevance 0.42
In humans, MIF protein has been localized in the prostate of cancer patients [2].
Localization (localized) of MIF protein associated with cancer
3) Confidence 0.80 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 1.06 Pain Relevance 0.34
MIF was localized mainly to epithelia of the bladder and the prostate.
Localization (localized) of MIF in bladder
4) Confidence 0.80 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.24 Pain Relevance 0.11
These findings, although preliminary, suggest to us that MIF may be released from prostate epithelia because of inflammatory events in other pelvic viscera (in this case, the bladder) and this release may be mediated by neurogenic reflexes.
Localization (released) of MIF in viscera associated with inflammation
5) Confidence 0.80 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 1.02 Pain Relevance 0.28
Co-immunoprecipitations studied MIF-CXCR4 associations.Urothelial basal and intermediate (but not superficial) cells in saline-treated rats contained CXCR4, co-localized with MIF.
Localization (localized) of MIF
6) Confidence 0.76 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2588654 Disease Relevance 0.43 Pain Relevance 0.18
This raises the possibility that these cells will be activated by MIF present in the urine and in fact, CYP (present study) and other inflammatory stimuli [8]–[10] increase luminal MIF release.
Localization (release) of MIF in urine associated with inflammatory stimuli
7) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.37 Pain Relevance 0.23
CXCR4 and MIF are co-localized in cells in the urothelium and CYP induced co-localization of CXCR4 and MIF to superficial cells of the urothelium.
Localization (localization) of MIF
8) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.57 Pain Relevance 0.45
Using dual immunohistochemistry we show that MIF and CXCR4 are colocalized within the same cells in the urothelium and co-immunoprecipitation studies demonstrate MIF-CXCR4 associations in the bladder.
Localization (colocalized) of MIF in bladder
9) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.73 Pain Relevance 0.12
In saline-treated rats, both MIF and CXCR4 could be localized in the basal and intermediate layers of the urothelium (but not in superficial cells) (Fig 4A–C).
Localization (localized) of MIF
10) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
In this study we confirm these in vitro finding since we demonstrate 1) co-localization of CXCR4 and MIF in the urothelium, both in saline treated rats and after CYP treatment; 2) CXCR4-MIF associations are present in saline-treated bladder and increase after CYP treatment.
Localization (localization) of MIF in bladder
11) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.43 Pain Relevance 0.34
Thus, based on our experimental evidence we consider likely that MIF is released into the lumen from pre-formed stores in the bladder during inflammation.
Localization (released) of MIF in bladder associated with inflammation
12) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.50 Pain Relevance 0.28
The anatomical location of MIF mRNA and protein has been described for the adult rat brain [7,8,20].
Localization (location) of MIF mRNA in brain
13) Confidence 0.75 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.90 Pain Relevance 0.32
Results in the present study revealed the location of MIF protein in the bladder and prostate of the rat and in the central and peripheral nervous system tissues that innervate these organs.
Localization (location) of MIF protein in bladder associated with peripheral nervous system
14) Confidence 0.75 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.26 Pain Relevance 0.17
CXCR4 immunostaining in urothelium: co-localization with MIF and effect of treatment with cyclophosphamide
Localization (localization) of MIF
15) Confidence 0.71 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.25 Pain Relevance 0.06
CXCR4 and MIF are co-localized in cells in the urothelium and CYP induced co-localization of CXCR4 and MIF to superficial cells of the urothelium.
Localization (localized) of MIF
16) Confidence 0.71 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.64 Pain Relevance 0.49
We examined the co-localization of CXCR4 and MIF in the urothelium using dual-immunofluorescence.
Localization (localization) of MIF
17) Confidence 0.71 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
CXCR4 and MIF are co-localized in cells in the urothelium and CYP induced co-localization of CXCR4 and MIF to superficial cells of the urothelium.
Localization (localization) of MIF
18) Confidence 0.71 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.64 Pain Relevance 0.49
The bladder contains stores of preformed macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, which is released into the lumen in response to SP.
Localization (released) of MIF in lumen associated with substance p and cytokine
19) Confidence 0.71 Published 2004 Journal J. Urol. Section Abstract Doc Link 15371880 Disease Relevance 0.44 Pain Relevance 0.63
In the dorsal horn, although the great majority of the MIF cells also localized GFAP, indicating they were glial in origin, some cells also showed only MIF staining without GFAP suggesting that MIF could also be localized in neurons (Fig 4B,4C).
Localization (localized) of MIF in neurons associated with dorsal horn
20) Confidence 0.71 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.26 Pain Relevance 0.24

General Comments

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