INT116744

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 12.77
Pain Relevance 5.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Pik3r1) protein complex (Pik3r1) cytoplasm (Pik3r1)
cytosol (Pik3r1) signal transduction (Pik3r1) nucleus (Pik3r1)
Anatomy Link Frequency
platelet 2
testis 1
neuron 1
oligodendrocyte 1
T cell 1
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 101 100.00 Very High Very High Very High
Arthritis 241 99.18 Very High Very High Very High
Central grey 2 98.20 Very High Very High Very High
agonist 5 95.16 Very High Very High Very High
opioid receptor 89 94.80 High High
Morphine 83 93.72 High High
cINOD 21 92.48 High High
chemokine 39 92.12 High High
Inflammation 248 90.80 High High
cytokine 146 89.36 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 101 100.00 Very High Very High Very High
Cancer 371 99.84 Very High Very High Very High
Sprains And Strains 139 99.48 Very High Very High Very High
Arthritis 256 99.18 Very High Very High Very High
Death 30 98.76 Very High Very High Very High
Urological Neuroanatomy 24 98.68 Very High Very High Very High
Apoptosis 58 97.80 Very High Very High Very High
Breast Cancer 42 97.56 Very High Very High Very High
Disease 153 97.44 Very High Very High Very High
Pressure And Volume Under Development 70 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the polyclonal antibody recognizing a p110gamma catalytic subunit of PI3Kgamma, PI3Kgamma-like immunoreactivity (IR) was mostly seen in the membrane of the cell labeled by anti-neuron-specific nuclear protein.
PI3K Binding (recognizing) of in neuron
1) Confidence 0.36 Published 2004 Journal Neuroscience Section Abstract Doc Link 14980723 Disease Relevance 0.42 Pain Relevance 0.68
The second step in the activation of mTORC1 by growth factors is the recruitment of IRS1/2 and PI3K to the receptor.
PI3K Binding (recruitment) of
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.11 Pain Relevance 0
B) complex, platelet-derived growth factor BB (PDGF BB), p38 mitogen- activated protein kinase (MAPK) and the phosphoinositide 3-kinase (PI3K) complex.
PI3K Binding (complex) of in platelet
3) Confidence 0.23 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 0.39 Pain Relevance 0.13
B) complex, platelet-derived growth factor BB (PDGF BB), p38 mitogen- activated protein kinase (MAPK) and the phosphoinositide 3-kinase (PI3K) complex.
PI3K Binding (complex) of in platelet
4) Confidence 0.23 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 0.38 Pain Relevance 0.13
Interestingly, Sco1, Sco5 and Whc1 displayed essentially normal gametogenesis suggesting that the M623, V667 in the ATP binding site and the F809 in the activation loop domain are not as important as the Y719 bound by the phosphatidylinositol 3'-kinase (PI3K) that is essential for Kit function in testis [20].
PI3K Binding (bound) of in testis
5) Confidence 0.19 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.30 Pain Relevance 0
The Ras/mitogen activated protein kinase (MAPK) pathway and the phosphoinositide 3-kinase (PI3K) pathway are activated primarily through SHC/FRS-2 binding to phosphorylated tyrosine (Y)515, whereas phosphorylated Y816 activates a calcium/calmodulin-dependent protein kinase II (CaMKII) pathway through PLC?.
PI3K Binding (binding) of
6) Confidence 0.17 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0 Pain Relevance 0.07
Binding to heterodimeric PI3K translocates this lipid kinase to the membrane (3) in contact with its substrates [61].
PI3K Binding (Binding) of
7) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.91
Indeed, co-immunoprecipitation assays demonstrated a constitutive interaction between JAK2 and the p85 subunit of PI3K (data not shown).
PI3K Binding (interaction) of
8) Confidence 0.15 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.03
Indeed, the action of PI3K in these cases appears to be mediated, at least in part, through the regulation of STAT1 serine 727 phosphorylation [11].
PI3K Binding (action) of
9) Confidence 0.15 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.48 Pain Relevance 0.04
AIA: antigen-induced arthritis; CIA: collagen-induced arthritis; mBSA: methylated bovine serum albumin; PI3K: phosphoinositide 3-kinase; RA: Rheumatoid arthritis

Competing interests

PI3K Binding (arthritis) of associated with rheumatoid arthritis and arthritis
10) Confidence 0.14 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 1.23 Pain Relevance 0.62
AIA: antigen-induced arthritis; CIA: collagen-induced arthritis; mBSA: methylated bovine serum albumin; PI3K: phosphoinositide 3-kinase; RA: Rheumatoid arthritis

Competing interests

PI3K Binding (interests) of associated with rheumatoid arthritis and arthritis
11) Confidence 0.14 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 1.23 Pain Relevance 0.62
These findings are in line with studies on PI3K?
PI3K Binding (line) of
12) Confidence 0.13 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 1.69 Pain Relevance 0.62
No differences between the strains could be detected, again pointing to normal T cell responses in the PI3K?
PI3K Binding (pointing) of in T cell associated with sprains and strains
13) Confidence 0.13 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.84 Pain Relevance 0.20
activating PI3K, Cdc42, and p21-activated kinase (PAK), which in turn
PI3K Binding (which) of
14) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.34 Pain Relevance 0
This is mediated through CD74, the subsequent engagement of p38 MAPK, ERK, Src kinase, phospholipase A2 and PI3K pathways [104-108], and the binding of NF-?
PI3K Binding (engagement) of
15) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.61 Pain Relevance 0.24
protects GC function appears to be mediated through the protection of HDAC-2 activity, it is also likely to include modulation of other corepressors, such as Mi-2 and mSin3a.55,97 The mechanism by which PI3K?
PI3K Spec (likely) Binding (mechanism) of
16) Confidence 0.10 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.74 Pain Relevance 0.07
The binding of growth factors or insulin to cell surface receptors activates the class 1a PI3K.
PI3K Binding (binding) of
17) Confidence 0.09 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.16 Pain Relevance 0
Recently, by the help of high-throughput genome and transcriptome analyses, human secondary GBs were shown to be similar to the proneural type of primary GBs and associated with PDGFRA amplification, TP53 and PTEN deletion/mutation, IDH1 mutation and also disturbances in the PI3K signaling pathway, and finally by the expression of oligodendrocyte markers [133].
PI3K Binding (associated) of in oligodendrocyte
18) Confidence 0.08 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.79 Pain Relevance 0
Thus, PI3K appears to link the spirochete-M?
PI3K Binding (link) of
19) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0 Pain Relevance 0
When combined with TNFalpha, Sulindac inhibited TNFalpha-induced tRXRalpha/p85alpha interaction, leading to activation of the death receptor-mediated apoptotic pathway.
p85alpha Binding (interaction) of associated with apoptosis and death
20) Confidence 0.05 Published 2010 Journal Cancer Cell Section Abstract Doc Link 20541701 Disease Relevance 0.72 Pain Relevance 0.31

General Comments

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