INT116747

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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 9.33
Pain Relevance 4.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Pik3r1) protein complex (Pik3r1) cytoplasm (Pik3r1)
cytosol (Pik3r1) signal transduction (Pik3r1) nucleus (Pik3r1)
Anatomy Link Frequency
joint 1
stromal cells 1
gray matter 1
muscle 1
osteoblasts 1
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 224 99.78 Very High Very High Very High
cytokine 97 99.68 Very High Very High Very High
agonist 27 99.66 Very High Very High Very High
opioid receptor 89 99.48 Very High Very High Very High
Kinase C 67 99.48 Very High Very High Very High
Inflammation 189 99.36 Very High Very High Very High
Morphine 132 98.94 Very High Very High Very High
Central grey 2 98.92 Very High Very High Very High
Nerve growth factor 2 93.48 High High
Pyramidal cell 2 90.80 High High
Disease Link Frequency Relevance Heat
Arthritis 236 99.78 Very High Very High Very High
Obesity 162 99.40 Very High Very High Very High
INFLAMMATION 204 99.36 Very High Very High Very High
Urological Neuroanatomy 34 98.92 Very High Very High Very High
Pressure And Volume Under Development 66 98.36 Very High Very High Very High
Disease 183 95.48 Very High Very High Very High
Apoptosis 68 95.48 Very High Very High Very High
Osteoporosis 14 92.44 High High
Reprotox - General 1 10 92.04 High High
Rheumatoid Arthritis 38 90.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to investigate whether in vivo treatment with morphine, a mu-opioid receptor (MOR) agonist, could directly regulate PI3Kgamma isoform in the mouse periaqueductal gray matter (PAG).
Regulation (regulate) of PI3K in gray matter associated with agonist, urological neuroanatomy, opioid receptor, central grey and morphine
1) Confidence 0.60 Published 2004 Journal Neuroscience Section Abstract Doc Link 14980723 Disease Relevance 0.40 Pain Relevance 0.68
The findings of this investigation suggested that activation of the MEK/ERK and the PI3K/Akt pathways and inhibition of p38MAPK pathway were involved in RANKL expression induced by MIP-1alpha in bone-marrow stromal cells and osteoblasts.
Regulation (involved) of PI3K in stromal cells
2) Confidence 0.30 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.49 Pain Relevance 0.04
Significant downregulation of these CCR9-mediated antiapoptotic proteins in the presence of a PI3K inhibitor (wortmannin), further suggests that the antiapoptotic action of CCR9 is primarily regulated through PI3K.
Regulation (regulated) of PI3K
3) Confidence 0.20 Published 2010 Journal Int. J. Cancer Section Abstract Doc Link 20127861 Disease Relevance 0.77 Pain Relevance 0.11
We also confirmed lack of involvement of the EP4-stimulated PI3K pathway by testing the effect of the PI3K inhibitor LY294002 on mitochondrial cationic dye release (54).
Regulation (effect) of PI3K
4) Confidence 0.20 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 0.23 Pain Relevance 0
In response to HF diet stimulation insulin signal transduction was suppressed due to down-regulation of Pik3r1, Pik3r2, and Akt2 genes.
Regulation (regulation) of Pik3r1
5) Confidence 0.19 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.22 Pain Relevance 0
The CK2- and PI3K-mediated regulation of Sp1/Sp3 binding could represent one such mechanism.


Regulation (regulation) of PI3K
6) Confidence 0.18 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.06 Pain Relevance 0
To determine whether the PI3K pathway was also involved in the cytokine-mediated reduction of Sp1/Sp3 binding to its recognition sequence in the LPL gene, the effect of pre-treatment of the cells with three different concentrations of the PI3K inhibitor LY294002 on the IFN-?
Spec (whether) Regulation (involved) of PI3K associated with cytokine
7) Confidence 0.18 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.05
Moreover, in a transwell chemotaxis assay, wildtype cells were much more responsive to C5a stimulation than PI3K?
Regulation (responsive) of PI3K
8) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.46 Pain Relevance 0.15
These observations were in contrast to both other studies on PI3K?
Regulation (were) of PI3K
9) Confidence 0.15 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 1.67 Pain Relevance 0.59
Genes downstream of the integrins, including phosphatidylinositol 3-kinase (PI3K), were altered, as well as genes regulated by the phosphatidylinositol signaling system (3-phosphoinositide dependent protein kinase and Vav oncogene).
Regulation (regulated) of PI3K
10) Confidence 0.14 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.40 Pain Relevance 0.33
This regulation integrates the positive effects of PI3K, Akt, nNOS, PKC, Src, NMDAR and CaMKII on MOR inhibition.
Regulation (effects) of PI3K associated with kinase c and opioid receptor
11) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.07 Pain Relevance 0.95
These results demonstrate the potential of AS-605240, especially to alleviate clinical signs of acute AIA (joint swelling) and, once again, prove that chronic inflammatory processes in the AIA model are independent of PI3K?.


Neg (independent) Regulation (independent) of PI3K in joint associated with pressure and volume under development, inflammation and arthritis
12) Confidence 0.11 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 1.23 Pain Relevance 0.47
Thus, influence of PI3K?
Regulation (influence) of PI3K
13) Confidence 0.11 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 1.29 Pain Relevance 0.62
The findings of this investigation suggested that activation of the MEK/ERK and the PI3K/Akt pathways and inhibition of p38MAPK pathway were involved in RANKL expression induced by MIP-1alpha in bone-marrow stromal cells and osteoblasts.
Regulation (involved) of PI3K in osteoblasts
14) Confidence 0.10 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.49 Pain Relevance 0.04
PI3K is insulin regulated and activates protein kinase B (PKB), otherwise known as AKT.
Regulation (regulated) of PI3K
15) Confidence 0.09 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.27 Pain Relevance 0.05
Two important targets of PI3K in muscle and fat cells that have been shown to have a role in insulin-stimulated GLUT-4 translocation are the AKT and the protein kinase C (PKC).
Regulation (targets) of PI3K in fat cells associated with kinase c and obesity
16) Confidence 0.08 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.16 Pain Relevance 0.09
A recent study defined class IA phosphoinositide 3-kinase (PI3K) as another direct target of resveratrol thus confirming earlier findings of involvement of resveratrol in the PI3K pathway (Frojdo et al 2007).
Regulation (target) of PI3K
17) Confidence 0.08 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546476 Disease Relevance 0.36 Pain Relevance 0.03
The mammalian target of rapamycin (mTOR), one of the targets of the PTEN/Pi3K pathway, is a conserved kinase that regulates central cellular functions in response to environmental signals, such as transcription and translation, mRNA and protein turnover, or autophagy (reviewed in [190, 191]).
Regulation (targets) of Pi3K
18) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.58 Pain Relevance 0.03
Two important targets of PI3K in muscle and fat cells that have been shown to have a role in insulin-stimulated GLUT-4 translocation are the AKT and the protein kinase C (PKC).
Regulation (targets) of PI3K in muscle associated with kinase c and obesity
19) Confidence 0.03 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.16 Pain Relevance 0.09
Reflecting critical roles of PTKs and PI3-K in early membrane-proximal TCR signaling [18], PP2 and Wortmannin treatments strongly inhibited the F-actin polymerization (Supplementary Figure S3A).
Regulation (roles) of PI3-K in proximal
20) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0 Pain Relevance 0

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