INT116748

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 9.83
Pain Relevance 4.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Pik3r1) protein complex (Pik3r1) cytoplasm (Pik3r1)
cytosol (Pik3r1) signal transduction (Pik3r1) nucleus (Pik3r1)
Anatomy Link Frequency
PAG 4
myoblast 2
external 2
skin 2
body 2
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 450 99.80 Very High Very High Very High
opioid receptor 10 99.70 Very High Very High Very High
Morphine 12 99.66 Very High Very High Very High
cytokine 186 99.22 Very High Very High Very High
Inflammatory response 32 98.94 Very High Very High Very High
Pain 25 96.56 Very High Very High Very High
Hyperalgesia 1 89.64 High High
Inflammation 177 89.08 High High
Peripheral sensitization 1 88.96 High High
Central grey 4 88.68 High High
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 8 100.00 Very High Very High Very High
Arthritis 474 99.80 Very High Very High Very High
Urological Neuroanatomy 12 99.44 Very High Very High Very High
INFLAMMATION 202 98.76 Very High Very High Very High
Lyme Disease 13 98.08 Very High Very High Very High
Pain 9 96.56 Very High Very High Very High
Immunization 24 94.84 High High
Disease 204 94.16 High High
Targeted Disruption 55 91.56 High High
Frailty 5 91.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Double immunolabeling assay showed that MOR-IR was mostly overlapped with PI3Kgamma-IR on the cell surface in the PAG section.
Positive_regulation (overlapped) of Gene_expression (overlapped) of PI3K in PAG associated with urological neuroanatomy and opioid receptor
1) Confidence 0.49 Published 2004 Journal Neuroscience Section Abstract Doc Link 14980723 Disease Relevance 0.44 Pain Relevance 0.88
A single s.c. injection of morphine caused a marked increase in the number of PI3Kgamma-IR expressing cells in the PAG.
Positive_regulation (increase) of Gene_expression (expressing) of PI3K in PAG associated with urological neuroanatomy and morphine
2) Confidence 0.49 Published 2004 Journal Neuroscience Section Abstract Doc Link 14980723 Disease Relevance 0.44 Pain Relevance 0.83
In skeletal muscle, enhanced PI3K expression or downstream signalling promotes myoblast differentiation [21] and skeletal muscle growth [6], [7] but does not result in transformation of terminally differentiated skeletal muscle [22], [23].
Positive_regulation (enhanced) of Gene_expression (expression) of PI3K in myoblast
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.14 Pain Relevance 0
Intraplantar injection of ephrinB1-Fc produced a time- and dose-dependent increase of PI3K-p110gamma expression and of phosphorylation of AKT in skin of injection site.
Positive_regulation (increase) of Gene_expression (expression) of PI3K in skin
4) Confidence 0.45 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20170671 Disease Relevance 0.33 Pain Relevance 0.38
Interestingly, a recent study investigating the mechanisms underlying the PI3K-mediated suppression of PMA-induced expression of p21WAF1/Cip1 showed that blocking of the PI3K/mTOR pathway was associated with increased binding by Sp1 [38].
Positive_regulation (induced) of Gene_expression (expression) of PI3K
5) Confidence 0.21 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.23 Pain Relevance 0.03
In conclusion, our studies provide novel insights into the role and mechanism of action of CK2 and PI3K signalling in the IFN-?
Positive_regulation (action) of Gene_expression (signalling) of PI3K
6) Confidence 0.21 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.07 Pain Relevance 0.03
An increasing body of evidence supports a role for the PI3K pathway in IFN-?
Positive_regulation (role) of Gene_expression (pathway) of PI3K in body
7) Confidence 0.21 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.40 Pain Relevance 0
, and IL-6, was not as strongly inhibited in this experiment, as was observed with PI3K?
Positive_regulation (observed) of Gene_expression (observed) of PI3K
8) Confidence 0.19 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.84 Pain Relevance 0.31
, and IL-6, was not as strongly inhibited in this experiment, as was observed with PI3K?
Positive_regulation (with) of Gene_expression (observed) of PI3K
9) Confidence 0.19 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.84 Pain Relevance 0.31
Thus, our results extend data of several groups, investigating PI3K?
Spec (investigating) Positive_regulation (investigating) of Spec (investigating) Gene_expression (investigating) of PI3K
10) Confidence 0.19 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.53 Pain Relevance 0.22
Randis et al. [21] induced arthritis by serum transfer from K/BxN mice to PI3K?
Positive_regulation (transfer) of Gene_expression (transfer) of PI3K associated with arthritis
11) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 1.51 Pain Relevance 0.52
It is important to note, that cytokine production in this experiment was not induced by external stimuli, specifically targeting GPCR receptors and PI3K?
Neg (not) Positive_regulation (induced) of Gene_expression (targeting) of PI3K in external associated with cytokine
12) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.70 Pain Relevance 0.29
Moreover, in two models of systemic lupus erythematosus, PI3K?
Positive_regulation (Moreover) of Gene_expression (Moreover) of PI3K associated with systemic lupus erythematosus
13) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.44 Pain Relevance 0.12
There were no significant differences observed between either anti-CD3-stimulated (data not shown) or mBSA-stimulated wildtype and PI3K?
Neg (no) Positive_regulation (stimulated) of Gene_expression (wildtype) of PI3K
14) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.69 Pain Relevance 0.22
By adding the selective PI3K?
Positive_regulation (selective) of Gene_expression (adding) of PI3K
15) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.41 Pain Relevance 0.13
Impaired insulin/IGF1 signalling results in the hyperphosphorylation of Tau due to reduced activation of PI3K/AKT and increased levels of GSK-3?
Positive_regulation (activation) of Gene_expression (/) of PI3K
16) Confidence 0.16 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.97 Pain Relevance 0.04
This was expected because the MAPK and PI-3-K
               pathways mediate the effect of mGlu3 receptor activation on TGF-? 
Positive_regulation (mediate) of Gene_expression (pathways) of PI-3-K
17) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0 Pain Relevance 0.06
Herein, this paradigm is challenged by demonstrating that recognition of live Borrelia burgdorferi not only triggers an inflammatory response in the absence of CD14, but one that is, in part, a consequence of altered PI3K/AKT/p38-MAPK signaling and impaired negative regulation of TLR2.
Positive_regulation (consequence) of Gene_expression (/) of PI3K associated with lyme disease and inflammatory response
18) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2781632 Disease Relevance 0.43 Pain Relevance 0.27
Zhang and colleagues [53] recently showed that the PI3-K/Akt axis activates OPN, which increases cell motility and anchorage independence.
Positive_regulation (activates) of Gene_expression (axis) of PI3-K
19) Confidence 0.04 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400667 Disease Relevance 0.44 Pain Relevance 0

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