INT116760

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.95
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Ikbkap) nucleus (Ikbkap) cytoplasm (Ikbkap)
Ikbkap (Mus musculus)
Pain Link Frequency Relevance Heat
unmyelinated 1 84.08 Quite High
Pain 2 71.92 Quite High
imagery 2 5.00 Very Low Very Low Very Low
Peripheral nervous system 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rare Diseases 2 97.68 Very High Very High Very High
Familial Dysautonomia 125 97.14 Very High Very High Very High
Pain 2 71.92 Quite High
Dysphagia 1 66.96 Quite High
Vomiting 1 66.08 Quite High
Ataxia 1 56.40 Quite High
Death 1 46.40 Quite Low
Renal Failure 1 41.12 Quite Low
Disease 11 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Second, a potential source of variability among transcriptome analyses derives from the technical manipulations employed to downregulate IKBKAP (presence of the FD mutation in its original context compared to WT IKBKAP knockdown using different interfering RNAs), resulting in differential residual IKBKAP/IKAP expression.
Gene_expression (expression) of IKAP associated with familial dysautonomia
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.34 Pain Relevance 0
Mutations result in tissue-specific expression of mutant IkappaB kinase-associated protein (IKAP).
Gene_expression (expression) of mutant IkappaB kinase-associated protein
2) Confidence 0.59 Published 2004 Journal Muscle Nerve Section Abstract Doc Link 14981733 Disease Relevance 0.61 Pain Relevance 0.11

General Comments

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