INT116784

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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.76
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
lateral 4
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 5 100.00 Very High Very High Very High
nMDA receptor 1 100.00 Very High Very High Very High
qutenza 18 99.84 Very High Very High Very High
Hyperalgesia 6 99.76 Very High Very High Very High
Inflammation 35 99.04 Very High Very High Very High
nociceptor 2 97.16 Very High Very High Very High
adenocard 1 97.12 Very High Very High Very High
Root ganglion neuron 1 95.36 Very High Very High Very High
dorsal root ganglion 107 94.40 High High
noradrenaline 7 90.60 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 7 99.76 Very High Very High Very High
INFLAMMATION 35 99.04 Very High Very High Very High
Nervous System Injury 10 98.24 Very High Very High Very High
Ganglion Cysts 108 94.96 High High
Fever 1 74.12 Quite High
Nociception 3 62.12 Quite High
Arthritis 30 54.80 Quite High
Pain 11 50.00 Quite Low
Arthralgia 3 5.00 Very Low Very Low Very Low
Inflammatory Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate: (a) an enhanced adrenergic regulation of P2X3 receptor activity at lateral sites following SNI where signaling afferents are directly influenced by injured neurons; (b) differential effects on adrenergic regulation of TRPV1 receptors under the same conditions; (c) lack of such changes when agents are administered into medial sites following SNI.
Regulation (effects) of Regulation (regulation) of TRPV1 in lateral associated with nervous system injury
1) Confidence 0.60 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18722504 Disease Relevance 0.77 Pain Relevance 0.57
These findings suggest the involvement of tachykinin NK2, CGRP and non-NMDA receptor systems in the vanilloid VR1 receptor-mediated regulation of gastric acid secretion in the rat brain regions close to the lateral cerebroventricle.
Regulation (involvement) of Regulation (regulation) of VR1 in lateral associated with nmda receptor and calcitonin gene-related peptide
2) Confidence 0.44 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14985054 Disease Relevance 0 Pain Relevance 0.58
In a second approach, we tested whether soluble mediators are responsible for the up-regulation of NK1, B2, and TRPV1 receptors that is observed in co-culture with FLS cells.
Spec (whether) Regulation (responsible) of Regulation (regulation) of TRPV1
3) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860064 Disease Relevance 0.54 Pain Relevance 0.27
On this basis, effects of baicalin on both the expression of TRPV1 mRNA and on the function of TRPV1 in vitro under two various temperature conditions were studied.
Regulation (effects) of Regulation (under) of TRPV1
4) Confidence 0.27 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 20380875 Disease Relevance 0.15 Pain Relevance 0
The responsiveness of TRPV1 is regulated by a series of intracellular signalling molecules including the cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA); increased or decreased PKA activity results in TRPV1 sensitisation or desensitisation, respectively.
Regulation (regulated) of Regulation (responsiveness) of TRPV1 associated with adenocard
5) Confidence 0.27 Published 2010 Journal Acta Physiol Hung Section Abstract Doc Link 20511124 Disease Relevance 0.20 Pain Relevance 0.37
In this study, we examined the role of the nonreceptor cellular tyrosine kinase c-Src kinase in the modulation of the rat TRPV1.
Spec (examined) Regulation (role) of Regulation (modulation) of TRPV1
6) Confidence 0.27 Published 2004 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 15084474 Disease Relevance 0.09 Pain Relevance 0.38

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