INT11679

Context Info Confidence 0.54 First Reported 1984 Last Reported 2010 Negated 2 Speculated 1 Reported most in Abstract Documents 55 Total Number 56 Disease Relevance 33.69 Pain Relevance 9.43

extracellular region (F13A1) transferase activity, transferring acyl groups (F13A1) cytoplasm (F13A1)

Anatomy Link Frequency platelet 3 joint 2 blood 2 cartilage 2 eyes 2 F13A1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 77 100.00 Pain 32 100.00 aspirin 49 99.92 rheumatoid arthritis 13 99.84 Angina 30 99.52 antagonist 8 99.40 Restless leg syndrome 60 99.28 withdrawal 6 99.06 metalloproteinase 9 98.74 abdominal pain 8 98.40

Disease Link Frequency Relevance Heat INFLAMMATION 94 100.00 Thrombosis 41 100.00 Pain 26 100.00 Coronary Artery Disease 3 99.92 Injury 75 99.90 Rheumatoid Arthritis 13 99.84 Infection 41 99.66 Adhesions 39 99.66 Cv General 3 Under Development 34 99.52 Purpura 26 99.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Three operated cases of congenital deficiency of factor XIII (fibrin-stabilizing factor) associated with intracranial hematomas were described and the diagnosis, replacement therapy of the factor were discussed.

Negative_regulation (deficiency) of factor XIII associated with hematoma

1) Confidence 0.54 Published 1984 Journal No Shinkei Geka Section Abstract Doc Link 6504254 Disease Relevance 0.63 Pain Relevance 0.10

Case 2: A 1.4-year-old boy with the history of umbilical bleeding on delivery and diagnosed as congenital deficiency of factor XIII in the other hospital fall down and struck his occiput on September 20, 1980.

Negative_regulation (deficiency) of factor XIII in occiput associated with hemorrhage

2) Confidence 0.54 Published 1984 Journal No Shinkei Geka Section Abstract Doc Link 6504254 Disease Relevance 1.51 Pain Relevance 0.15

[3 operated cases of congenital deficiency of Factor XIII associated with intracranial hematomas].

Negative_regulation (deficiency) of Factor XIII associated with hematoma

3) Confidence 0.54 Published 1984 Journal No Shinkei Geka Section Title Doc Link 6504254 Disease Relevance 1.16 Pain Relevance 0.12

Congenital deficiency of factor XIII is quite rare coagulation disorder and only 100 patients were reported in the literatures in which we could find only one case who had craniotomy for associated intracranial hemorrhage.

Negative_regulation (deficiency) of factor XIII associated with coagulation disorder and cva

4) Confidence 0.54 Published 1984 Journal No Shinkei Geka Section Abstract Doc Link 6504254 Disease Relevance 0.91 Pain Relevance 0.12

After 31 days, the relative wound area had reduced by 42%, with an associated decrease in fibrin and an increase in granulation tissue.

Negative_regulation (decrease) of fibrin in granulation

5) Confidence 0.47 Published 2008 Journal J Wound Care Section Body Doc Link 18546995 Disease Relevance 0.13 Pain Relevance 0

Fibrinolytic therapy, aimed at reducing pericapillary fibrin and restoring proper physiologic exchanges between blood and tissues, may benefit some patients with extensive and nonhealing ulcers.

Negative_regulation (reducing) of fibrin in blood associated with ulcers

6) Confidence 0.47 Published 1986 Journal J. Am. Acad. Dermatol. Section Abstract Doc Link 3519695 Disease Relevance 0.35 Pain Relevance 0.09

After precoating was accomplished with fibrinolytically inhibited fibrin glue, a 10 mm expanded polytetrafluoroethylene graft was confluently lined with the autologous endothelial cells at a seeding density of 1.2 x 10(5) cells/cm2.

Negative_regulation (inhibited) of fibrin in endothelial cells

7) Confidence 0.47 Published 1994 Journal J. Vasc. Surg. Section Abstract Doc Link 8126870 Disease Relevance 0.29 Pain Relevance 0.09

A prolonged increase in fibrinolysis may decrease joint fibrin deposition and lead to clinical improvement and we have therefore investigated stanozolol as a therapeutic agent.

Negative_regulation (decrease) of fibrin in joint

8) Confidence 0.38 Published 1986 Journal Q. J. Med. Section Abstract Doc Link 3517926 Disease Relevance 0.48 Pain Relevance 0.13

Fibrin deposition in rheumatoid arthritis may be responsible for some of the clinical manifestations of the disease.

Negative_regulation (deposition) of Fibrin associated with rheumatoid arthritis and disease

9) Confidence 0.38 Published 1986 Journal Q. J. Med. Section Abstract Doc Link 3517926 Disease Relevance 0.41 Pain Relevance 0.13

Protective fibrinolytic enzyme systems of the peritoneum, such as the plasmin system, can remove the fibrin gel matrix.

Negative_regulation (remove) of fibrin in peritoneum

10) Confidence 0.37 Published 1997 Journal Eur J Surg Suppl Section Abstract Doc Link 9076453 Disease Relevance 1.24 Pain Relevance 0.06

Significant alterations on vessel walls took place few minutes after venom application, characterised by increment in thickness, probably by deposition of fibrin.

Negative_regulation (deposition) of fibrin

11) Confidence 0.37 Published 2002 Journal Toxicon Section Abstract Doc Link 12165317 Disease Relevance 0.29 Pain Relevance 0.14

Although arthroscopy was not necessary, it facilitated fibrin removal, lavage, and partial synovectomy.

Spec (partial) Negative_regulation (removal) of fibrin

12) Confidence 0.35 Published 1991 Journal Vet Surg Section Abstract Doc Link 2008770 Disease Relevance 0.32 Pain Relevance 0.20

On day 4 granulation tissue covered the walls of the cavity and the amount of necrotic tissue and fibrin was reduced.

Negative_regulation (reduced) of fibrin in cavity

13) Confidence 0.35 Published 2009 Journal Tech Coloproctol Section Abstract Doc Link 19603139 Disease Relevance 0.52 Pain Relevance 0.09

The surgical approach included complete transection of the palmar/plantar annular ligament of the fetlock and proximal digital annular ligament, which facilitated the removal of fibrin, selective debridement and synovectomy, followed by lavage of the digital sheath.

Negative_regulation (removal) of fibrin in annular ligament

14) Confidence 0.35 Published 2000 Journal Vet. Rec. Section Abstract Doc Link 11073001 Disease Relevance 0.56 Pain Relevance 0.08

Postoperative adhesions are sequelae of impaired fibrinolysis of the fibrin and cellular exudate after peritoneal injury.

Negative_regulation (impaired) of fibrin associated with injury and adhesions

15) Confidence 0.34 Published 1994 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 8178880 Disease Relevance 1.71 Pain Relevance 0.14

A trauma of the penis with subsequent deposition of fibrin and formation of a fibrotic plaque in the tunica albuginea is the most likely pathophysiological mechanism.

Negative_regulation (deposition) of fibrin in tunica albuginea associated with fibrosis and injury

16) Confidence 0.34 Published 2004 Journal Expert Rev Pharmacoecon Outcomes Res Section Abstract Doc Link 19807528 Disease Relevance 0.93 Pain Relevance 0.20

A biomaterial composed of carboxymethylcellulose, poly(ethylene oxide), and calcium can be prepared in a variety of ways to reduce fibrin deposition and adhesion formation.

Negative_regulation (reduce) of fibrin in poly associated with adhesions

17) Confidence 0.34 Published 2007 Journal J. Biomed. Mater. Res. Part B Appl. Biomater. Section Abstract Doc Link 16969823 Disease Relevance 0.30 Pain Relevance 0.05

In chronic arteriopathy, the thrombus is lacking or almost lacking in fibrin and thrombolytic therapy is not indicated.

Negative_regulation (lacking) of fibrin associated with thrombosis

18) Confidence 0.34 Published 1985 Journal Angiology Section Abstract Doc Link 2932987 Disease Relevance 0.62 Pain Relevance 0.04

B. diffusa was found most effective in reducing stromal edema, inflammation, and tortuosity of glands, and in increasing the degree of deposition of fibrin and platelets in the vessel lumen.

Negative_regulation (deposition) of fibrin in lumen associated with pressure and volume under development and inflammation

19) Confidence 0.34 Published 1990 Journal Adv Contracept Section Abstract Doc Link 2403030 Disease Relevance 0.63 Pain Relevance 0.35

These have spurred the development of novel drugs, such as platelet fibrinogen receptor antagonists, plasminogen activators, and inhibitors of factor IIa (thrombin) and XIIIa.

Negative_regulation (inhibitors) of XIIIa in platelet associated with antagonist

20) Confidence 0.21 Published 1990 Journal FASEB J. Section Abstract Doc Link 2210155 Disease Relevance 0.40 Pain Relevance 0.16

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