INT116797

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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.12
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 3
DRGs 2
trigeminal ganglia 1
nucleus 1
adipocyte 1
Osmr (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 20 99.96 Very High Very High Very High
cytokine 14 98.46 Very High Very High Very High
mu opioid receptor 27 98.30 Very High Very High Very High
Spinal cord 14 97.36 Very High Very High Very High
Substantia nigra 5 62.52 Quite High
Visceral pain 1 40.24 Quite Low
Hippocampus 3 34.88 Quite Low
nociceptor 12 25.00 Low Low
Pain 2 25.00 Low Low
imagery 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 8 98.88 Very High Very High Very High
Rheumatoid Arthritis 4 95.32 Very High Very High Very High
Hematological Disease 2 85.28 High High
Obesity 5 83.84 Quite High
Leukemia 3 81.32 Quite High
Targeted Disruption 59 74.48 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 40.24 Quite Low
Syndrome 70 5.00 Very Low Very Low Very Low
Congenital Anomalies 24 5.00 Very Low Very Low Very Low
Convulsion 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast with the CNS, OSMRbeta was strongly expressed in small-sized non-peptidergic neurons of the dorsal root ganglia (DRG) and trigeminal ganglia (TG).
Gene_expression (expressed) of OSMRbeta in trigeminal ganglia associated with central nervous system
1) Confidence 0.73 Published 2005 Journal Anat Sci Int Section Abstract Doc Link 15794131 Disease Relevance 0.15 Pain Relevance 0.25
Oncostatin M (OSM) is a member of the interleukin-6 family of cytokines, and we have reported previously that the murine OSM receptor beta subunit (OSMR) was expressed in some neurons in the adult trigeminal and dorsal root ganglia (DRGs) and in the perineonatal hypoglossal nucleus.
Gene_expression (expressed) of OSMR in neurons associated with cytokine
2) Confidence 0.66 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14985435 Disease Relevance 0.07 Pain Relevance 0.05
In the CNS of neonatal mice, OSMRbeta was also expressed in the ventral subnucleus of the hypoglossal nucleus, but disappeared at post-natal day (P) 14.
Gene_expression (expressed) of OSMRbeta in nucleus associated with central nervous system
3) Confidence 0.57 Published 2005 Journal Anat Sci Int Section Abstract Doc Link 15794131 Disease Relevance 0.17 Pain Relevance 0.26
MEFs (Table S3) could also be found, through literature searches, to exhibit expression positively correlated with adipocyte differentiation, including Adm, Lpar1, Osmr, and Ptx3 [69],[71],[72].
Gene_expression (expression) of Osmr in adipocyte
4) Confidence 0.48 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730539 Disease Relevance 0.17 Pain Relevance 0.03
We previously demonstrated OSMRbeta-expressing neurons to decrease, however, they were not found to disappear in oncostatin M (OSM) -deficient mice.
Gene_expression (expressing) of OSMRbeta in neurons
5) Confidence 0.44 Published 2006 Journal Neuroscience Section Abstract Doc Link 16926070 Disease Relevance 0.14 Pain Relevance 0.04
These findings suggest that IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons.
Gene_expression (expressing) of OSMRbeta in neurons
6) Confidence 0.44 Published 2006 Journal Neuroscience Section Abstract Doc Link 16926070 Disease Relevance 0.08 Pain Relevance 0.04
In our previous reports, we demonstrated that OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).
Gene_expression (expressed) of OSMRbeta in DRGs associated with nociception
7) Confidence 0.44 Published 2006 Journal Neuroscience Section Abstract Doc Link 16926070 Disease Relevance 0.10 Pain Relevance 0.09
We also found that the developmental expression pattern of IL-31RA was different from that of OSMRbeta; IL31RA-positive neurons in DRGs first appeared at postnatal day (PN) 10 and reached the adult level at PN14, whereas OSMRbeta-positive neurons were observed at PN0 for the first time.
Gene_expression (expression) of OSMRbeta in DRGs
8) Confidence 0.38 Published 2006 Journal Neuroscience Section Abstract Doc Link 16926070 Disease Relevance 0.17 Pain Relevance 0.10
Mismatches have been observed for mu opioid receptors when comparing in situ hybridization, immunoreactivity and receptor binding between receptor mRNA and protein expression [59,60].
Gene_expression (expression) of receptor mRNA associated with mu opioid receptor
9) Confidence 0.01 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.07 Pain Relevance 0.14

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