INT116798

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Context Info
Confidence 0.77
First Reported 2004
Last Reported 2011
Negated 2
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.74
Pain Relevance 3.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Osm) extracellular region (Osm)
Anatomy Link Frequency
neurons 3
joints 2
dorsal root ganglia 2
ciliary 1
Osm (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 100 99.98 Very High Very High Very High
nociceptor 6 99.82 Very High Very High Very High
Arthritis 176 99.12 Very High Very High Very High
rheumatoid arthritis 103 98.88 Very High Very High Very High
Inflammation 96 96.00 Very High Very High Very High
antagonist 3 95.68 Very High Very High Very High
chemokine 10 94.32 High High
Inflammatory response 14 84.72 Quite High
Spinal cord 3 82.80 Quite High
Visceral pain 2 57.84 Quite High
Disease Link Frequency Relevance Heat
Leukemia 2 100.00 Very High Very High Very High
Arthritis 183 99.12 Very High Very High Very High
Rheumatoid Arthritis 107 98.88 Very High Very High Very High
INFLAMMATION 112 96.00 Very High Very High Very High
Disease 123 91.56 High High
Anaemia 1 82.04 Quite High
Fever 1 81.64 Quite High
Necrosis 6 75.92 Quite High
Cancer 7 75.56 Quite High
Nociception 7 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oncostatin M (OSM) is a member of the interleukin-6 family of cytokines, and we have reported previously that the murine OSM receptor beta subunit (OSMR) was expressed in some neurons in the adult trigeminal and dorsal root ganglia (DRGs) and in the perineonatal hypoglossal nucleus.
Gene_expression (expressed) of OSM receptor in neurons associated with cytokine
1) Confidence 0.77 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14985435 Disease Relevance 0.07 Pain Relevance 0.05
In the present study, we investigated the development of OSMR-positive neurons of DRGs in OSM-deficient mice.
Gene_expression (deficient) of OSM in DRGs
2) Confidence 0.60 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14985435 Disease Relevance 0.07 Pain Relevance 0.10
We previously demonstrated OSMRbeta-expressing neurons to decrease, however, they were not found to disappear in oncostatin M (OSM) -deficient mice.
Neg (not) Gene_expression (-deficient) of oncostatin M in neurons
3) Confidence 0.57 Published 2006 Journal Neuroscience Section Abstract Doc Link 16926070 Disease Relevance 0.14 Pain Relevance 0.04
We previously demonstrated OSMRbeta-expressing neurons to decrease, however, they were not found to disappear in oncostatin M (OSM) -deficient mice.
Neg (not) Gene_expression (-deficient) of OSM in neurons
4) Confidence 0.57 Published 2006 Journal Neuroscience Section Abstract Doc Link 16926070 Disease Relevance 0.13 Pain Relevance 0.04
Complete overlap of interleukin-31 receptor A and oncostatin M receptor beta in the adult dorsal root ganglia with distinct developmental expression patterns.
Gene_expression (overlap) of oncostatin M in dorsal root ganglia associated with nociceptor
5) Confidence 0.57 Published 2006 Journal Neuroscience Section Title Doc Link 16926070 Disease Relevance 0.07 Pain Relevance 0.29
Overexpression of oncostatin M in the mouse joints induced synovial pathology [61] and anti-oncostatin M treatment suppressed arthritis [62], except in one study in which human oncostatin M treatment was shown to inhibit CAIA [63].
Gene_expression (Overexpression) of oncostatin M in joints associated with arthritis
6) Confidence 0.22 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.48 Pain Relevance 0.85
Overexpression of oncostatin M in the mouse joints induced synovial pathology [61] and anti-oncostatin M treatment suppressed arthritis [62], except in one study in which human oncostatin M treatment was shown to inhibit CAIA [63].
Gene_expression (Overexpression) of anti-oncostatin M in joints associated with arthritis
7) Confidence 0.17 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.48 Pain Relevance 0.86
IL-6 family cytokines consist of IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CP-1).
Gene_expression (consist) of oncostatin M in ciliary associated with leukemia and cytokine
8) Confidence 0.13 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 1.22 Pain Relevance 0.77

General Comments

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