INT1168

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Context Info
Confidence 0.38
First Reported 1975
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 62
Total Number 66
Disease Relevance 44.15
Pain Relevance 9.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PROC) extracellular space (PROC) extracellular region (PROC)
plasma membrane (PROC)
Anatomy Link Frequency
brain 2
monocyte 2
macrophages 1
lateral 1
lymphocytes 1
PROC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 417 100.00 Very High Very High Very High
Osteoarthritis 150 100.00 Very High Very High Very High
Paracetamol 5 100.00 Very High Very High Very High
Neurotransmitter 5 99.80 Very High Very High Very High
cINOD 43 99.68 Very High Very High Very High
Bile 39 99.28 Very High Very High Very High
diclofenac 10 99.04 Very High Very High Very High
mu opioid receptor 14 97.76 Very High Very High Very High
backache 14 97.54 Very High Very High Very High
Pain 37 96.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Prostate Cancer 598 100.00 Very High Very High Very High
INFLAMMATION 466 100.00 Very High Very High Very High
Papillomavirus Infection 407 100.00 Very High Very High Very High
Infection 289 100.00 Very High Very High Very High
Disease 285 100.00 Very High Very High Very High
Cancer 208 100.00 Very High Very High Very High
Viral Infection 202 100.00 Very High Very High Very High
Osteoarthritis 156 100.00 Very High Very High Very High
Pancreatic Cancer 88 100.00 Very High Very High Very High
Reprotox - General 1 82 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We could not identify previous reports describing ways to engage with PC patients around research prioritisation, likely related to the difficulty of carrying out research with people who suffer from a highly lethal cancer.
PC Binding (engage) of associated with cancer and pancreatic cancer
1) Confidence 0.38 Published 2010 Journal Cancer Causes Control Section Body Doc Link PMC2855814 Disease Relevance 0.82 Pain Relevance 0
Based on our studies, we postulate the formation of PC to be taking place in multilayers and multistages.
PC Binding (formation) of associated with calculi
2) Confidence 0.36 Published 1987 Journal Pancreas Section Abstract Doc Link 3628220 Disease Relevance 0.64 Pain Relevance 0.06
Human factors were involved in 41.9% of the patients reported, most commonly associated with unfamiliar technique/inexperience, inattention and inadequate communication.
factors Binding (associated) of associated with attention deficit hyperactivity disorder
3) Confidence 0.30 Published 1998 Journal Anaesthesia Section Abstract Doc Link 9797515 Disease Relevance 0.52 Pain Relevance 0.58
Acute pancreatitis (AP) has been recognized as a presentation of patients with pancreatic carcinoma (PC).
PC Binding (recognized) of associated with pancreatic cancer and pancreatitis
4) Confidence 0.30 Published 2000 Journal Pancreas Section Abstract Doc Link 11075985 Disease Relevance 1.41 Pain Relevance 0
The values of excess molar enthalpy of solutions are negative and very low in magnitude indicating no specific interaction between DS and PC in solution.
PC Neg (no) Binding (interaction) of in molar associated with paracetamol
5) Confidence 0.29 Published 2003 Journal J Pharm Biomed Anal Section Abstract Doc Link 12467923 Disease Relevance 0 Pain Relevance 0.50
The IIA and its side-branch were selectively catheterized with a 5 Fr Cobra 1 catheter (Cordis, Roden, The Netherlands).
IIA Binding (catheterized) of
6) Confidence 0.24 Published 2007 Journal Cardiovasc Intervent Radiol Section Body Doc Link PMC1964782 Disease Relevance 0.74 Pain Relevance 0.08
The total PC was measured by activating the bound PC in the wells by Protac (American Diagnostica, Greenwich, CT, USA) and then measuring the amidolytic activity with the chromogenic substrate S-2366 (Chromogenix AB).
PC Binding (bound) of
7) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0 Pain Relevance 0
There is no question that low-back pain is an extremely significant cause of disability and has a major socioeconomic impact, but many different personal and job factors are associated with the incidence and prevalence of these complaints.
factors Binding (associated) of associated with backache
8) Confidence 0.21 Published 1992 Journal Occup Med Section Abstract Doc Link 1411850 Disease Relevance 0.62 Pain Relevance 0.54
Association between clinician factors and a patient's wish to hasten death: terminally ill cancer patients and their doctors.
factors Binding (Association) of associated with cancer and death
9) Confidence 0.21 Published 2004 Journal Psychosomatics Section Title Doc Link 15232045 Disease Relevance 0.79 Pain Relevance 0.09
In severe AP, levels of PC and APC were moderately associated with monocyte activation status.
PC Binding (associated) of in monocyte associated with pancreatitis
10) Confidence 0.21 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 1.16 Pain Relevance 0.28
DISCUSSION: This study confirms results from a previous study that sociodemographic and economic status, preinjury health status, and collision-related factors are associated with participants' rating of initial neck pain intensity in WAD.
factors Binding (associated) of in neck
11) Confidence 0.20 Published 2007 Journal Clin J Pain Section Body Doc Link 17710009 Disease Relevance 0 Pain Relevance 0
In our present study, PC was associated with no mortality and low morbidity.
PC Binding (associated) of
12) Confidence 0.20 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2880266 Disease Relevance 0.70 Pain Relevance 0.16
Key messages

• Severe AP patients suffer from significant PC pathway pathology, which is associated with the development of organ failure. • Monocyte HLA-DR% correlated with PC and APC levels, indicating interaction between inflammation and the PC pathway in severe AP. • Modulating the PC pathway might improve the outcome of severe AP patients.


PC Binding (interaction) of in Monocyte associated with inflammation and pancreatitis
13) Confidence 0.18 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 1.69 Pain Relevance 0.17
Associations between general coagulation screening parameters and PC pathway components were analysed.
PC Spec (analysed) Binding (Associations) of
14) Confidence 0.18 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.06 Pain Relevance 0
This case demonstrates the use of an allograft and synthetic bone graft material with growth factors in the treatment of a benign tibial bone tumor, avoiding the comorbidity and risk factors associated with autogeneic grafting.
factors Binding (associated) of associated with bone cancer
15) Confidence 0.16 Published 2006 Journal J Am Podiatr Med Assoc Section Abstract Doc Link 16868330 Disease Relevance 0.53 Pain Relevance 0.09
Topics that are covered include the peroxisome proliferation caused by a wide variety of chemical compounds, the metabolic implications of this phenomenon, interactions between peroxisomal transcription factors and the eicosanoids, and the close relationships between peroxisomal metabolism and the control of functional damage caused by oxygen free radicals.
factors Binding (interactions) of
16) Confidence 0.16 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9751070 Disease Relevance 0 Pain Relevance 0.08
Non-steroidal anti-inflammatory drugs (NSAIDs) induce intestinal injury in direct proportion to their ability to be excreted into bile, and are known to chemically associate with PC.
PC Binding (associate) of in bile associated with bile, injury and cinod
17) Confidence 0.15 Published 2008 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 18086111 Disease Relevance 0.27 Pain Relevance 0.38
Analysis of choline-containing metabolites showed that the major label association with phosphocholine and PC was reduced to a similar extent which was also parallel to the inhibition of choline uptake.
PC Binding (association) of
18) Confidence 0.12 Published 1994 Journal Cell Biochem. Funct. Section Abstract Doc Link 8044894 Disease Relevance 0 Pain Relevance 0.48
Hepatocytes exposed to SDC showed injury that could be dose-dependently prevented by PC, and reversed by indomethacin.
PC Binding (prevented) of in Hepatocytes
19) Confidence 0.10 Published 2008 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 18086111 Disease Relevance 0.07 Pain Relevance 0
The multimodal and multi-region treatment approach delivered likely reflects the complex multi-factorial aetiology of hamstring and lower-limb injuries which have been said to result from a complex interaction of multiple risk factors and events, of which only a fraction have been identified [28].
factors Binding (interaction) of in limb associated with injury
20) Confidence 0.04 Published 2010 Journal Chiropr Osteopat Section Body Doc Link PMC2927600 Disease Relevance 0.32 Pain Relevance 0

General Comments

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