INT116802

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Context Info
Confidence 0.20
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.77
Pain Relevance 3.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Camk4) nucleoplasm (Camk4) signal transduction (Camk4)
nucleocytoplasmic transport (Camk4) nucleus (Camk4) cytoplasm (Camk4)
Anatomy Link Frequency
NAc 1
spinal 1
cortex 1
Camk4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 11 100.00 Very High Very High Very High
Kinase C 9 100.00 Very High Very High Very High
Eae 1 100.00 Very High Very High Very High
isoflurane 8 99.66 Very High Very High Very High
Nucleus accumbens 4 99.24 Very High Very High Very High
Inflammation 12 98.92 Very High Very High Very High
long-term potentiation 16 97.80 Very High Very High Very High
IPN 4 97.52 Very High Very High Very High
c fibre 6 96.76 Very High Very High Very High
spinal dorsal horn 8 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 1 99.44 Very High Very High Very High
INFLAMMATION 8 98.92 Very High Very High Very High
Inflammatory Pain 4 97.52 Very High Very High Very High
Nociception 34 96.28 Very High Very High Very High
Schizophrenia 3 89.64 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

27 78.28 Quite High
Ganglion Cysts 6 77.68 Quite High
Hyperalgesia 1 65.48 Quite High
Pain 5 54.12 Quite High
Anaerobic Bacterial Infections 1 16.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AIM: To investigate the effects of chronic ethanol intake on the locomotor activity and the levels of calcium/calmodulin-dependent protein kinase IV (CaM kinase IV) in the nucleus accumbens (NAc) of rats.
Spec (investigate) Regulation (effects) of kinase IV in NAc associated with nucleus accumbens and eae
1) Confidence 0.20 Published 2008 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 18501110 Disease Relevance 0 Pain Relevance 0.45
[Role of phospho-calcium/ calmodulin-dependent protein kinase II in the induction and maintenance of long-term potentiation of C-fiber-evoked field potentials in spinal dorsal horn of the rat].
Regulation ([Role) of calmodulin-dependent in spinal associated with c fibre, spinal dorsal horn and long-term potentiation
2) Confidence 0.04 Published 2004 Journal Sheng Li Xue Bao Section Title Doc Link 14985835 Disease Relevance 0 Pain Relevance 0.74
In conclusion, our results suggest that inflammatory acidic environments activate Trpv1, leading to an up-regulation of CGRP expression via CaMK-CREB cascade, a series of events that may be associated with inflammatory pain.
Regulation (regulation) of CaMK associated with inflammation, ipn and calcitonin gene-related peptide
3) Confidence 0.03 Published 2010 Journal Mol. Biol. Cell Section Abstract Doc Link 20534813 Disease Relevance 1.02 Pain Relevance 1.12
In the current study, the effects of selected psychoactive drugs were investigated using Western blotting, in situ hybridization and immunocytochemistry to determine if they target CaM, calmodulin-dependent protein kinases (CaMK) or calcineurin.
Regulation (target) of CaMK
4) Confidence 0.02 Published 2009 Journal Neuroscience Section Abstract Doc Link 19289156 Disease Relevance 0.17 Pain Relevance 0
Additionally, it has been reported that isoflurane or propofol may influence various signaling transduction pathways such as PKC, CaMK, ERK, etc in hypoxic or normal cortex neurons [85-88].
Spec (may) Regulation (influence) of CaMK in cortex associated with kinase c, hypoxia and isoflurane
5) Confidence 0.00 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.43 Pain Relevance 0.99

General Comments

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