INT116802

Context Info Confidence 0.20 First Reported 2004 Last Reported 2010 Negated 0 Speculated 2 Reported most in Abstract Documents 4 Total Number 5 Disease Relevance 1.77 Pain Relevance 3.29

cytosol (Camk4) nucleoplasm (Camk4) signal transduction (Camk4) nucleocytoplasmic transport (Camk4) nucleus (Camk4) cytoplasm (Camk4)

Anatomy Link Frequency NAc 1 spinal 1 cortex 1 Camk4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Calcitonin gene-related peptide 11 100.00 Kinase C 9 100.00 Eae 1 100.00 isoflurane 8 99.66 Nucleus accumbens 4 99.24 Inflammation 12 98.92 long-term potentiation 16 97.80 IPN 4 97.52 c fibre 6 96.76 spinal dorsal horn 8 95.36

Disease Link Frequency Relevance Heat Hypoxia 1 99.44 INFLAMMATION 8 98.92 Inflammatory Pain 4 97.52 Nociception 34 96.28 Schizophrenia 3 89.64 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super / Visceral Pain 27 78.28 Ganglion Cysts 6 77.68 Hyperalgesia 1 65.48 Pain 5 54.12 Anaerobic Bacterial Infections 1 16.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

AIM: To investigate the effects of chronic ethanol intake on the locomotor activity and the levels of calcium/calmodulin-dependent protein kinase IV (CaM kinase IV) in the nucleus accumbens (NAc) of rats.

Spec (investigate) Regulation (effects) of kinase IV in NAc associated with nucleus accumbens and eae

1) Confidence 0.20 Published 2008 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 18501110 Disease Relevance 0 Pain Relevance 0.45

[Role of phospho-calcium/ calmodulin-dependent protein kinase II in the induction and maintenance of long-term potentiation of C-fiber-evoked field potentials in spinal dorsal horn of the rat].

Regulation ([Role) of calmodulin-dependent in spinal associated with c fibre, spinal dorsal horn and long-term potentiation

2) Confidence 0.04 Published 2004 Journal Sheng Li Xue Bao Section Title Doc Link 14985835 Disease Relevance 0 Pain Relevance 0.74

In conclusion, our results suggest that inflammatory acidic environments activate Trpv1, leading to an up-regulation of CGRP expression via CaMK-CREB cascade, a series of events that may be associated with inflammatory pain.

Regulation (regulation) of CaMK associated with inflammation, ipn and calcitonin gene-related peptide

3) Confidence 0.03 Published 2010 Journal Mol. Biol. Cell Section Abstract Doc Link 20534813 Disease Relevance 1.02 Pain Relevance 1.12

In the current study, the effects of selected psychoactive drugs were investigated using Western blotting, in situ hybridization and immunocytochemistry to determine if they target CaM, calmodulin-dependent protein kinases (CaMK) or calcineurin.

Regulation (target) of CaMK

4) Confidence 0.02 Published 2009 Journal Neuroscience Section Abstract Doc Link 19289156 Disease Relevance 0.17 Pain Relevance 0

Additionally, it has been reported that isoflurane or propofol may influence various signaling transduction pathways such as PKC, CaMK, ERK, etc in hypoxic or normal cortex neurons [85-88].

Spec (may) Regulation (influence) of CaMK in cortex associated with kinase c, hypoxia and isoflurane

5) Confidence 0.00 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.43 Pain Relevance 0.99

General Comments

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