INT116815

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.86
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pias1) molecular_function (Ppbp) enzyme binding (Pias1)
DNA binding (Pias1) biological_process (Ppbp) ligase activity (Pias1)
Pias1 (Mus musculus)
Ppbp (Mus musculus)
Pain Link Frequency Relevance Heat
Gabapentin 36 100.00 Very High Very High Very High
antiepileptic Drug 12 98.80 Very High Very High Very High
anticonvulsant 2 85.36 High High
Neurotransmitter 1 32.28 Quite Low
GABAergic 1 31.60 Quite Low
Disease Link Frequency Relevance Heat
Convulsion 15 98.88 Very High Very High Very High
Epilepsy 2 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From a preclinical point of view, the interactions observed experimentally showed that the combination of TGB and GBP, due to a synergistic anti-seizure activity of the drugs, might provide adequate seizure control in patients with refractory epilepsy.
GBP Spec (might) Binding (combination) of TGB associated with epilepsy, convulsion and gabapentin
1) Confidence 0.36 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14985937 Disease Relevance 0.51 Pain Relevance 0.65
The aim of this study was to characterise the types of interactions between gabapentin (GBP), tiagabine (TGB) and three second-generation antiepileptic drugs (AEDs) with different mechanisms of action (felbamate [FBM], loreclezole [LCZ], and oxcarbazepine [OXC]) by isobolographic analysis.
GBP Binding (interactions) of TGB associated with antiepileptic drug and gabapentin
2) Confidence 0.18 Published 2005 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 16133488 Disease Relevance 0.14 Pain Relevance 0.50
Also, the combinations of GBP with FBM, GBP with LCZ, and TGB with OXC are beneficial.
GBP Binding (combinations) of TGB associated with gabapentin
3) Confidence 0.16 Published 2005 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 16133488 Disease Relevance 0.21 Pain Relevance 0.77

General Comments

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