INT116819

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.75
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) transport (TRPV1) plasma membrane (TRPV1)
lipid metabolic process (TRPV1)
Anatomy Link Frequency
nerve 2
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
vanilloid receptor subtype 1 9 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
Botox 29 99.98 Very High Very High Very High
Kinase C 6 99.52 Very High Very High Very High
Dorsal horn 3 99.48 Very High Very High Very High
Glutamate receptor 1 96.96 Very High Very High Very High
trigger zone 2 96.24 Very High Very High Very High
qutenza 8 95.16 Very High Very High Very High
Glutamate 5 95.16 Very High Very High Very High
Face pain 4 93.60 High High
Disease Link Frequency Relevance Heat
Headache 6 93.60 High High
Pain 132 91.36 High High
Muscular Spasm 2 86.60 High High
Syndrome 5 84.84 Quite High
Plantar Fasciitis 1 84.08 Quite High
Skin Appendage Disease 1 83.24 Quite High
Spasticity 1 81.64 Quite High
Pruritus 2 81.36 Quite High
Cervical Cancer 1 80.76 Quite High
Ganglion Cysts 4 79.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, a description of VR1 localization in other cutaneous compartments in particular cutaneous nerve fibers is still lacking.
Negative_regulation (description) of Localization (localization) of VR1 in nerve associated with vanilloid receptor subtype 1
1) Confidence 0.43 Published 2004 Journal Exp. Dermatol. Section Abstract Doc Link 14987252 Disease Relevance 0.29 Pain Relevance 0.73
Botulinum neurotoxin A blocked the TRPV1 membrane translocation induced by PKC that was activated with a phorbol ester or the metabotropic glutamate receptor mGluR5.
Negative_regulation (blocked) of Localization (translocation) of TRPV1 associated with kinase c and glutamate receptor
2) Confidence 0.40 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15066994 Disease Relevance 0.14 Pain Relevance 0.63
Botox reduced the release of substance P, calcitonin gene-related protein, and vanilloid receptors (such as TRPV1).
Negative_regulation (reduced) of Localization (release) of TRPV1 associated with substance p and botox
3) Confidence 0.20 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2990447 Disease Relevance 1.31 Pain Relevance 1.35

General Comments

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