INT116829

Context Info Confidence 0.39 First Reported 2004 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 2 Total Number 4 Disease Relevance 0 Pain Relevance 1.02

nucleoplasm (Itpr3) transport (Itpr3) endoplasmic reticulum (Itpr3) nucleolus (Itpr3) nucleus (Itpr3) transmembrane transport (Itpr3)

Itpr3 (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 2 99.64 anesthesia 6 98.76 agonist 2 96.56 Potency 3 94.04 Adelta 1 78.56 c fibre 1 77.68 nociceptor 1 77.04 tail-flick 1 69.84 member 8 6 46.64

Disease Link Frequency Relevance Heat Hypersensitivity 6 5.00 Diabetes Mellitus 3 5.00 Adenoma 3 5.00 Adhesions 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, bupivacaine was unaffected by the IP3 channel antagonists xestospongin C or low molecular weight heparin.

Neg (unaffected) Regulation (unaffected) of IP3 associated with antagonist

1) Confidence 0.39 Published 2004 Journal Eur J Pain Section Abstract Doc Link 14987625 Disease Relevance 0 Pain Relevance 1.02

In taste cells, calmyrin/CIB1 has been suggested to interact with T1r2 and modulates IP3-evoked calcium release, recently (Hennigs et al. 2008).

Regulation (modulates) of IP3

2) Confidence 0.37 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0

A number of IP3Rs-binding proteins are known to regulate the IP3-Ca2+ signal cascade (Choe and Ehrlich 2006), and their differential distribution is thought to produce various signal transduction in various organs, although little is known about such regulators in taste cells.

Regulation (regulate) of IP3

3) Confidence 0.22 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0

In this paper, we describe the selective expression patterns in taste tissues and the novel molecular properties of Lrmp/Jaw1 and discuss its possible role as a candidate regulator of IP3-Ca2+ signal cascade in sweet, bitter, and umami taste signal transduction.

Spec (possible) Regulation (regulator) of IP3

4) Confidence 0.22 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.