INT116829

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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Itpr3) transport (Itpr3) endoplasmic reticulum (Itpr3)
nucleolus (Itpr3) nucleus (Itpr3) transmembrane transport (Itpr3)
Itpr3 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 2 99.64 Very High Very High Very High
anesthesia 6 98.76 Very High Very High Very High
agonist 2 96.56 Very High Very High Very High
Potency 3 94.04 High High
Adelta 1 78.56 Quite High
c fibre 1 77.68 Quite High
nociceptor 1 77.04 Quite High
tail-flick 1 69.84 Quite High
member 8 6 46.64 Quite Low
Disease Link Frequency Relevance Heat
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 3 5.00 Very Low Very Low Very Low
Adenoma 3 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, bupivacaine was unaffected by the IP3 channel antagonists xestospongin C or low molecular weight heparin.
Neg (unaffected) Regulation (unaffected) of IP3 associated with antagonist
1) Confidence 0.39 Published 2004 Journal Eur J Pain Section Abstract Doc Link 14987625 Disease Relevance 0 Pain Relevance 1.02
In taste cells, calmyrin/CIB1 has been suggested to interact with T1r2 and modulates IP3-evoked calcium release, recently (Hennigs et al. 2008).
Regulation (modulates) of IP3
2) Confidence 0.37 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0
A number of IP3Rs-binding proteins are known to regulate the IP3-Ca2+ signal cascade (Choe and Ehrlich 2006), and their differential distribution is thought to produce various signal transduction in various organs, although little is known about such regulators in taste cells.
Regulation (regulate) of IP3
3) Confidence 0.22 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0
In this paper, we describe the selective expression patterns in taste tissues and the novel molecular properties of Lrmp/Jaw1 and discuss its possible role as a candidate regulator of IP3-Ca2+ signal cascade in sweet, bitter, and umami taste signal transduction.


Spec (possible) Regulation (regulator) of IP3
4) Confidence 0.22 Published 2010 Journal Chemical Senses Section Body Doc Link PMC2805811 Disease Relevance 0 Pain Relevance 0

General Comments

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