INT116831

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 0.12
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ryr1) plasma membrane (Ryr1) cytoplasm (Ryr1)
Anatomy Link Frequency
skeletal muscle 1
reticulum 1
Ryr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 3 98.20 Very High Very High Very High
member 8 7 94.96 High High
tail-flick 1 93.12 High High
anesthesia 7 90.00 High High
Glutamate 8 75.00 Quite High
agonist 2 74.00 Quite High
antagonist 2 50.08 Quite High
c fibre 1 25.00 Low Low
Adelta 1 25.00 Low Low
nociceptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Disease 14 63.24 Quite High
Hypokalemic Periodic Paralysis 29 61.04 Quite High
Channelopathies 17 50.00 Quite Low
Malignant Hyperthermia 8 41.60 Quite Low
Renal Failure 1 35.60 Quite Low
Myoglobinuria 1 34.08 Quite Low
Hyperkalemia 1 32.64 Quite Low
Rhabdomyolysis 1 30.12 Quite Low
Acidosis 1 28.00 Quite Low
Hypercapnia 1 26.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results support the hypothesis that TRPC3 and RyR1 are functionally engaged via linker proteins in skeletal muscle.
RyR1 Binding (engaged) of in skeletal muscle
1) Confidence 0.47 Published 2008 Journal Biochem. J. Section Abstract Doc Link 18215135 Disease Relevance 0 Pain Relevance 0
However, it has not been possible to demonstrate direct protein-protein interactions between TRPC3 and RyR1.
RyR1 Binding (interactions) of
2) Confidence 0.47 Published 2008 Journal Biochem. J. Section Abstract Doc Link 18215135 Disease Relevance 0 Pain Relevance 0.09
TRPC1 was identified as a potential physical link between TRPC3 and RyR1, as it interacted with both TRPC3 and RyR1, and JPs showed subtype-specific interactions with both RyR1 and TRPC3 (JP1-RyR1 and JP2-TRPC3).
RyR1 Binding (interactions) of
3) Confidence 0.47 Published 2008 Journal Biochem. J. Section Abstract Doc Link 18215135 Disease Relevance 0 Pain Relevance 0.05
TRPC1 was identified as a potential physical link between TRPC3 and RyR1, as it interacted with both TRPC3 and RyR1, and JPs showed subtype-specific interactions with both RyR1 and TRPC3 (JP1-RyR1 and JP2-TRPC3).
RyR1 Binding (interacted) of
4) Confidence 0.47 Published 2008 Journal Biochem. J. Section Abstract Doc Link 18215135 Disease Relevance 0 Pain Relevance 0.05
The hypothesis was tested that drugs that bind RyR or IP3 channels would affect the anesthetic potency of bupivacaine.
RyR Binding (bind) of associated with potency
5) Confidence 0.44 Published 2004 Journal Eur J Pain Section Abstract Doc Link 14987625 Disease Relevance 0 Pain Relevance 0.47
However we again found no direct interaction between TRPC3 and RyR1.
RyR1 Neg (no) Binding (interaction) of
6) Confidence 0.37 Published 2008 Journal Biochem. J. Section Abstract Doc Link 18215135 Disease Relevance 0 Pain Relevance 0.06
TRPC1 was identified as a potential physical link between TRPC3 and RyR1, as it interacted with both TRPC3 and RyR1, and JPs showed subtype-specific interactions with both RyR1 and TRPC3 (JP1-RyR1 and JP2-TRPC3).
RyR1 Binding (interactions) of
7) Confidence 0.37 Published 2008 Journal Biochem. J. Section Abstract Doc Link 18215135 Disease Relevance 0 Pain Relevance 0.05
1S subunit interacts closely with RyR1 and is an important determinant of skeletal type EC coupling [4, 5].
RyR1 Spec (determinant) Binding (interacts) of
8) Confidence 0.34 Published 2001 Journal BMC Physiol Section Body Doc Link PMC37314 Disease Relevance 0 Pain Relevance 0
Further, the interactions between DHPR subunits and RyR1 also are incompletely understood.
RyR1 Binding (interactions) of
9) Confidence 0.34 Published 2001 Journal BMC Physiol Section Body Doc Link PMC37314 Disease Relevance 0 Pain Relevance 0
In addition to this orthograde coupling, there is also a retrograde signaling because the activity of DHPRs is strongly influenced by its RyR1 interaction.
RyR1 Binding (interaction) of
10) Confidence 0.30 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.12 Pain Relevance 0
In mouse skeletal myotubes, functional interaction between TRPC3 and RyR1 (ryanodine receptor type 1/Ca(2+)-release channel on sarcoplasmic reticulum membrane) regulates the gain of excitation-contraction coupling.
RyR1 Binding (interaction) of in reticulum
11) Confidence 0.29 Published 2009 Journal Mol. Cell. Biochem. Section Abstract Doc Link 19277847 Disease Relevance 0 Pain Relevance 0.13
Domains in the cytoplasmic linker between repeats II and III have been clearly implicated [14-19], and some regions such as Thr671-Lue690 were suggested to trigger RyR1 opening by binding to RyR1 [15].
RyR1 Binding (binding) of
12) Confidence 0.19 Published 2001 Journal BMC Physiol Section Body Doc Link PMC64647 Disease Relevance 0 Pain Relevance 0

General Comments

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