INT116836

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.76
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (FAP) extracellular space (FAP) plasma membrane (FAP)
Anatomy Link Frequency
colon 1
cavity 1
FAP (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 7 99.82 Very High Very High Very High
spastic colon 4 99.32 Very High Very High Very High
Opioid 2 97.00 Very High Very High Very High
cINOD 17 95.84 Very High Very High Very High
Pain 3 91.76 High High
nud 1 75.00 Quite High
COX-2 inhibitor 3 71.36 Quite High
Inflammation 5 50.00 Quite Low
Potency 2 25.76 Quite Low
nociceptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 102 100.00 Very High Very High Very High
Familial Adenomatous Polyposis 74 100.00 Very High Very High Very High
Desmoid Disease 59 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

4 100.00 Very High Very High Very High
Abdominal Pain 7 99.82 Very High Very High Very High
Syndrome 39 97.96 Very High Very High Very High
Polyps 36 96.44 Very High Very High Very High
Colorectal Cancer 50 95.68 Very High Very High Very High
Functional Bowel Disorder 1 95.00 High High
Adenomatous Polyps 6 86.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both IBS and FAP are associated with rectal hypersensitivity.
FAP Binding (associated) of associated with abdominal pain
1) Confidence 0.37 Published 2008 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 18376243 Disease Relevance 0.63 Pain Relevance 1.00
The association between desmoid tumors and FAP is particularly strong in patients with Gardner's syndrome [2].
FAP Binding (association) of associated with syndrome, cancer, familial adenomatous polyposis and desmoid disease
2) Confidence 0.31 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2955058 Disease Relevance 1.69 Pain Relevance 0
However, surgical excision provides for only a narrow therapeutic window, when desmoid tumours are located in the abdominal cavity and recur even if they are not associated with FAP.
FAP Binding (associated) of in cavity associated with cancer, familial adenomatous polyposis and desmoid disease
3) Confidence 0.19 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2270274 Disease Relevance 1.27 Pain Relevance 0.29
Patients with FAP present with total colonic polyposis, initially affecting the colon, with the number of polyps increasing over time to between 100-5000.
FAP Binding (Patients) of in colon associated with familial adenomatous polyposis and polyps
4) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 2.87 Pain Relevance 0
The structure activity research revealed that hemorphins N-terminus sequence influences nature of the interaction between hemorphins and DPPIV.
DPPIV Binding (interaction) of
5) Confidence 0.03 Published 2004 Journal Biochimie Section Abstract Doc Link 14987798 Disease Relevance 0 Pain Relevance 0.09
Hemorphins N-terminus sequence influence on the interaction between hemorphins and DPPIV.
DPPIV Binding (interaction) of
6) Confidence 0.03 Published 2004 Journal Biochimie Section Title Doc Link 14987798 Disease Relevance 0 Pain Relevance 0.10

General Comments

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