INT116836

Context Info Confidence 0.37 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 6.76 Pain Relevance 1.47

peptidase activity (FAP) extracellular space (FAP) plasma membrane (FAP)

Anatomy Link Frequency colon 1 cavity 1 FAP (Homo sapiens)

Pain Link Frequency Relevance Heat abdominal pain 7 99.82 spastic colon 4 99.32 Opioid 2 97.00 cINOD 17 95.84 Pain 3 91.76 nud 1 75.00 COX-2 inhibitor 3 71.36 Inflammation 5 50.00 Potency 2 25.76 nociceptor 1 25.00

Disease Link Frequency Relevance Heat Cancer 102 100.00 Familial Adenomatous Polyposis 74 100.00 Desmoid Disease 59 100.00 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 4 100.00 Abdominal Pain 7 99.82 Syndrome 39 97.96 Polyps 36 96.44 Colorectal Cancer 50 95.68 Functional Bowel Disorder 1 95.00 Adenomatous Polyps 6 86.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Both IBS and FAP are associated with rectal hypersensitivity.

FAP Binding (associated) of associated with abdominal pain

1) Confidence 0.37 Published 2008 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 18376243 Disease Relevance 0.63 Pain Relevance 1.00

The association between desmoid tumors and FAP is particularly strong in patients with Gardner's syndrome [2].

FAP Binding (association) of associated with syndrome, cancer, familial adenomatous polyposis and desmoid disease

2) Confidence 0.31 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2955058 Disease Relevance 1.69 Pain Relevance 0

However, surgical excision provides for only a narrow therapeutic window, when desmoid tumours are located in the abdominal cavity and recur even if they are not associated with FAP.

FAP Binding (associated) of in cavity associated with cancer, familial adenomatous polyposis and desmoid disease

3) Confidence 0.19 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2270274 Disease Relevance 1.27 Pain Relevance 0.29

Patients with FAP present with total colonic polyposis, initially affecting the colon, with the number of polyps increasing over time to between 100-5000.

FAP Binding (Patients) of in colon associated with familial adenomatous polyposis and polyps

4) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 2.87 Pain Relevance 0

The structure activity research revealed that hemorphins N-terminus sequence influences nature of the interaction between hemorphins and DPPIV.

DPPIV Binding (interaction) of

5) Confidence 0.03 Published 2004 Journal Biochimie Section Abstract Doc Link 14987798 Disease Relevance 0 Pain Relevance 0.09

Hemorphins N-terminus sequence influence on the interaction between hemorphins and DPPIV.

DPPIV Binding (interaction) of

6) Confidence 0.03 Published 2004 Journal Biochimie Section Title Doc Link 14987798 Disease Relevance 0 Pain Relevance 0.10

General Comments

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