INT11684

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Context Info
Confidence 0.36
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.30
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF2, IL3) extracellular region (CSF2, IL3) cell-cell signaling (IL3)
Anatomy Link Frequency
granulocyte 4
platelet 1
CSF2 (Homo sapiens)
IL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 99.46 Very High Very High Very High
headache 4 88.92 High High
Paracetamol 4 76.24 Quite High
ischemia 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heparin-induced Thrombocytopenia 12 99.82 Very High Very High Very High
Disease 5 98.74 Very High Very High Very High
Ovarian Cancer 4 98.16 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 4 97.48 Very High Very High Very High
Dyspnea 2 93.36 High High
Rigor 1 92.84 High High
Chills 1 92.56 High High
Increased Venous Pressure Under Development 1 89.32 High High
Headache 4 88.92 High High
Fever 1 88.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report on four cases (two of metastatic breast cancer, one of metastatic ovarian cancer and one of Hodgkin's disease) with prolonged chemotherapy-induced thrombocytopenia in whom rhIL-3 in combination with either recombinant human (rh) granulocyte macrophage colony stimulating factor (GM-CSF) or rh granulocyte colony stimulating factor (G-CSF) was administered.
G-CSF Binding (combination) of rhIL-3 in granulocyte associated with ovarian cancer, heparin-induced thrombocytopenia, disease and advanced or metastatic breast cancer
1) Confidence 0.36 Published 1997 Journal Anticancer Drugs Section Abstract Doc Link 9095335 Disease Relevance 0.68 Pain Relevance 0.12
We report on four cases (two of metastatic breast cancer, one of metastatic ovarian cancer and one of Hodgkin's disease) with prolonged chemotherapy-induced thrombocytopenia in whom rhIL-3 in combination with either recombinant human (rh) granulocyte macrophage colony stimulating factor (GM-CSF) or rh granulocyte colony stimulating factor (G-CSF) was administered.
granulocyte macrophage colony stimulating factor Binding (combination) of rhIL-3 in granulocyte associated with ovarian cancer, heparin-induced thrombocytopenia, disease and advanced or metastatic breast cancer
2) Confidence 0.31 Published 1997 Journal Anticancer Drugs Section Abstract Doc Link 9095335 Disease Relevance 0.62 Pain Relevance 0.12
We report on four cases (two of metastatic breast cancer, one of metastatic ovarian cancer and one of Hodgkin's disease) with prolonged chemotherapy-induced thrombocytopenia in whom rhIL-3 in combination with either recombinant human (rh) granulocyte macrophage colony stimulating factor (GM-CSF) or rh granulocyte colony stimulating factor (G-CSF) was administered.
GM-CSF Binding (combination) of rhIL-3 in granulocyte associated with ovarian cancer, heparin-induced thrombocytopenia, disease and advanced or metastatic breast cancer
3) Confidence 0.31 Published 1997 Journal Anticancer Drugs Section Abstract Doc Link 9095335 Disease Relevance 0.62 Pain Relevance 0.12
We report on four cases (two of metastatic breast cancer, one of metastatic ovarian cancer and one of Hodgkin's disease) with prolonged chemotherapy-induced thrombocytopenia in whom rhIL-3 in combination with either recombinant human (rh) granulocyte macrophage colony stimulating factor (GM-CSF) or rh granulocyte colony stimulating factor (G-CSF) was administered.
granulocyte colony stimulating factor Binding (combination) of rhIL-3 in granulocyte associated with ovarian cancer, heparin-induced thrombocytopenia, disease and advanced or metastatic breast cancer
4) Confidence 0.31 Published 1997 Journal Anticancer Drugs Section Abstract Doc Link 9095335 Disease Relevance 0.68 Pain Relevance 0.12
These results indicate that sequential treatment with rhIL-3 and rhGM-CSF is as effective as single-factor treatment with rhIL-3 in stimulating platelet counts, whereas the effect of combination therapy on neutrophil counts and circulating progenitor cells is superior.
rhGM-CSF Binding (treatment) of rhIL-3 in platelet
5) Confidence 0.28 Published 1992 Journal Blood Section Abstract Doc Link 1586711 Disease Relevance 0.69 Pain Relevance 0.15
Its receptor (EPOR) is a homodimeric transmembrane protein of 508 amino acids in humans (507 in mice) that belongs to a superfamily of cytokine receptors, which includes receptors for GM-CSF and interleukin-3 and -6 [1].
GM-CSF Binding (receptors) of interleukin-3 associated with cytokine
6) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0 Pain Relevance 0.09

General Comments

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