INT116842

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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.31
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2J2) endoplasmic reticulum (CYP2J2)
Anatomy Link Frequency
renal artery 1
CYP2J2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 16 33.68 Quite Low
anesthesia 1 25.00 Low Low
Inflammation 68 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Nicotine 2 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 233 99.84 Very High Very High Very High
Nicotine Addiction 68 98.78 Very High Very High Very High
Adenocarcinoma 2 98.28 Very High Very High Very High
Metastasis 6 96.96 Very High Very High Very High
Skin Cancer 2 96.20 Very High Very High Very High
Prostate Cancer 14 92.44 High High
Adhesions 2 90.48 High High
Malignant Neoplastic Disease 6 88.72 High High
Carcinoma 7 83.72 Quite High
Increased Venous Pressure Under Development 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specific CYP2J2 inhibitors suppress human tumor cell proliferation [122].
Negative_regulation (inhibitors) of CYP2J2 associated with cancer
1) Confidence 0.39 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.50 Pain Relevance 0
These results showing that CYP2J2 can be suppressed in tumors were confirmed by Leclerc et al. [128].
Negative_regulation (suppressed) of CYP2J2 associated with cancer
2) Confidence 0.39 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 1.17 Pain Relevance 0
A significant decrease (30–90%) was observed in the formation of various metabolites following incubation of verapamil with sulfaphenazole (10 µM), a CYP2C inhibitor, or ketoconazole (1 µM), a compound known to inhibit CYP3As and CYP2J2.
Negative_regulation (inhibit) of CYP2J2
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0 Pain Relevance 0
In bronchial biopsies of smokers, CYP1A1, CYP1B1, CYP2C9, GSTP1, and GSTA2 were induced, but CYP2J2 and EPHX1 were repressed.
Negative_regulation (repressed) of CYP2J2 associated with nicotine addiction
4) Confidence 0.13 Published 2006 Journal Environ Health Perspect Section Abstract Doc Link PMC1665420 Disease Relevance 0.56 Pain Relevance 0
This study examined the effects of renal arterial infusion of a selective cytochrome P-450 epoxygenase inhibitor, N-methylsulfonyl-6-(2-propargyloxyphenyl)hexanamide (MS-PPOH; 2 mg/kg plus 1.5 mg.kg(-1).h(-1)), on renal hemodynamic responses to infusions of [Phe(2),Ile(3),Orn(8)]vasopressin and ANG II into the renal artery of anesthetized rabbits.
Spec (examined) Negative_regulation (inhibitor) of epoxygenase in renal artery
5) Confidence 0.00 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14988086 Disease Relevance 0.07 Pain Relevance 0

General Comments

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