INT11685

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1980
Last Reported 2010
Negated 7
Speculated 5
Reported most in Body
Documents 99
Total Number 106
Disease Relevance 58.82
Pain Relevance 15.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF2) extracellular region (CSF2)
Anatomy Link Frequency
CSF 14
plasma 10
brain 5
macrophage 4
blood 4
CSF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 183 100.00 Very High Very High Very High
Pain 47 100.00 Very High Very High Very High
Enkephalin 8 99.98 Very High Very High Very High
Dynorphin 5 99.94 Very High Very High Very High
transcutaneous nerve stimulation 4 99.92 Very High Very High Very High
Central nervous system 489 99.84 Very High Very High Very High
Inflammation 434 99.84 Very High Very High Very High
Multiple sclerosis 381 99.84 Very High Very High Very High
headache 110 99.84 Very High Very High Very High
cINOD 24 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 1591 100.00 Very High Very High Very High
Disease 1325 100.00 Very High Very High Very High
Sleep Disorders 300 100.00 Very High Very High Very High
Parkinson's Disease 155 100.00 Very High Very High Very High
Infection 1573 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 102 99.90 Very High Very High Very High
INFLAMMATION 478 99.84 Very High Very High Very High
Demyelinating Disease 473 99.84 Very High Very High Very High
Headache 205 99.84 Very High Very High Very High
Pain 47 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results strongly suggest that oxytocin levels in human plasma and CSF are controlled by different mechanisms and that the increased oxytocin could have some specific central actions.
Regulation (controlled) of CSF in CSF
1) Confidence 0.59 Published 1985 Journal Endocrinol. Jpn. Section Abstract Doc Link 3833528 Disease Relevance 0.08 Pain Relevance 0.08
Our findings demonstrate that GM-CSF is regulated by NSAIDs and NO-NSAIDs via inhibition of COX and appears to be mediated via the cAMP pathway.
Regulation (regulated) of GM-CSF associated with cinod
2) Confidence 0.53 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680249 Disease Relevance 0.05 Pain Relevance 0.77
These results suggest that brain/CSF sodium rhythms are differentially regulated from the systemic circulation.
Regulation (regulated) of CSF in brain
3) Confidence 0.52 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2822736 Disease Relevance 0 Pain Relevance 0
The regulation responsible for these CSF sodium rhythms is of interest.
Regulation (regulation) of CSF
4) Confidence 0.52 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2822736 Disease Relevance 0.10 Pain Relevance 0
The change of CSF [Na+] that we report (10 mM from the data in Figure 5, and over 40 mM in Figure 1) will reflect changes in brain sodium.
Regulation (change) of CSF in brain
5) Confidence 0.52 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2822736 Disease Relevance 0.05 Pain Relevance 0
NKAT rhythms have been reported in the mammalian brain [27], and NKAT is clearly involved in [Na+]csf regulation [31-33].
Regulation (regulation) of csf in brain
6) Confidence 0.52 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2822736 Disease Relevance 0.07 Pain Relevance 0
The alterations in CSF beta-endorphin levels may play a role in these neurologic disorders and/or in central nervous system (CNS) infections.
Regulation (alterations) of CSF in CSF associated with neurological disease, central nervous system and infection
7) Confidence 0.46 Published 1993 Journal Kurume Med J Section Abstract Doc Link 8007632 Disease Relevance 0.94 Pain Relevance 0.12
While the ANOVA analysis that include all of the groups did not show a difference between the successes and failures, a simple comparison between these two groups suggested a significant difference (p = 0.0004 using Mann Whitney test) consistent with the view that more effective viral control had an effect on CSF neopterin.
Regulation (effect) of CSF
8) Confidence 0.43 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 0.34 Pain Relevance 0.18
Additionally, longitudinal changes in CSF cystatin C levels may be useful as a biomarker of fast versus slow rates of disease progression.
Regulation (changes) of CSF associated with disease progression
9) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.79 Pain Relevance 0
We completed a similar analysis and also found no evidence for a patterned directional change in CSF cystatin C levels over time in ALS patients (Figure 1).
Regulation (change) of CSF associated with motor neuron diseases
10) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 1.12 Pain Relevance 0.04
For comparison, we also assessed the longitudinal change in CSF cystatin C levels in 10 healthy controls, each with two CSF samples drawn 1.5–2 years apart.
Regulation (change) of CSF
11) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.17 Pain Relevance 0
In conclusion, the results of the reported studies suggest that a treatment designed to modulate intestinal mucosa immune homeostasis (including innate immunity and the T regulatory network) with colony-stimulating factors such as G-CSF and GM-CSF might have a role in patients with Crohn’s disease.



Regulation (modulate) of G-CSF associated with disease
12) Confidence 0.41 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621411 Disease Relevance 0.57 Pain Relevance 0
In conclusion, the results of the reported studies suggest that a treatment designed to modulate intestinal mucosa immune homeostasis (including innate immunity and the T regulatory network) with colony-stimulating factors such as G-CSF and GM-CSF might have a role in patients with Crohn’s disease.



Regulation (modulate) of GM-CSF associated with disease
13) Confidence 0.41 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621411 Disease Relevance 0.57 Pain Relevance 0
Furthermore, Harbord and colleagues (2006) have examined the composition of exudate in patients with CD and ulcerative colitis (UC), and assessed the effect of G-CSF administration on tissue penetration of neutrophils in patients.
Regulation (effect) of G-CSF in neutrophils associated with inflammatory bowel disease and disease
14) Confidence 0.41 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621411 Disease Relevance 1.40 Pain Relevance 0.20
A lumbar puncture demonstrated a significant lymphocytic response and an elevated CSF protein level on the day of and 24 days after the headache despite the absence of any other clinical symptoms.
Regulation (response) of CSF in puncture associated with headache and lumbar puncture related headaches
15) Confidence 0.39 Published 1980 Journal Arch. Neurol. Section Abstract Doc Link 7387469 Disease Relevance 0.37 Pain Relevance 0.36
Effects of recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndromes.
Regulation (Effects) of granulocyte-macrophage colony-stimulating factor in macrophage associated with myelodysplastic syndromes
16) Confidence 0.39 Published 1987 Journal N. Engl. J. Med. Section Title Doc Link 3500414 Disease Relevance 0.47 Pain Relevance 0
While this allows axial spread of the administered agent, our results show that subtle factors such as drug speed of injection, orientation of the injecting needle, and the amount of fluid administered will have a differentiating effect on the pattern of drug distribution in the CSF.
Regulation (effect) of CSF
17) Confidence 0.39 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC3005107 Disease Relevance 0 Pain Relevance 0.14
The refined model, updated using flow scans from MRI, allows us to address the motivating question of this project to understand the influence of CSF dynamics on the resulting drug concentration levels measured in sparse data from clinical trials.
Regulation (influence) of CSF
18) Confidence 0.39 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC3005107 Disease Relevance 0 Pain Relevance 0.13
Results from initial cine MRI measurements for the oscillating CSF mass flow in the cervical region due to intracranial pressure changes were in the same order as what we determined in the cervical region using our model based on literature.
Regulation (oscillating) of CSF in cervical region associated with cva
19) Confidence 0.39 Published 2010 Journal J Pharmacokinet Pharmacodyn Section Body Doc Link PMC3005107 Disease Relevance 0.10 Pain Relevance 0.05
Two patients died within the first 3 days after starting GM-CSF, although both seemed to have some response to GM-CSF (increasing blood neutrophils in one, and increasing macrophages in the bone marrow on autopsy in the other).
Regulation (response) of GM-CSF in macrophages
20) Confidence 0.39 Published 1990 Journal Clin Invest Med Section Abstract Doc Link 2191816 Disease Relevance 0.69 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox