INT116855

Context Info Confidence 0.04 First Reported 2003 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.78 Pain Relevance 0

signal transduction (TNFRSF10A) transcription factor binding (TNFRSF10A)

Anatomy Link Frequency liver 1 TNFRSF10A (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 1 27.20 palliative 2 5.00

Disease Link Frequency Relevance Heat Death 14 100.00 Hepatitis 1 99.30 Injury 1 98.00 Carcinoma 94 91.76 Apoptosis 114 91.48 Cancer 23 83.16 Necrosis 2 82.92 Targeted Disruption 4 71.56 Sepsis 1 61.16 Toxicity 4 60.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Modulation of death receptor pathways in oncology.

Regulation (Modulation) of death receptor associated with death

1) Confidence 0.04 Published 2003 Journal Drugs Today Section Title Doc Link 14988748 Disease Relevance 0.92 Pain Relevance 0

In a mouse model of fulminant hepatitis, intravenous application of siRNA targeting the death receptor CD95 (APO-1/Fas) was capable of preventing liver injury [57].

Regulation (targeting) of death receptor in liver associated with injury, death and hepatitis

2) Confidence 0.03 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.86 Pain Relevance 0

General Comments

This test has worked.