INT116856

Context Info Confidence 0.75 First Reported 2003 Last Reported 2011 Negated 1 Speculated 7 Reported most in Body Documents 110 Total Number 117 Disease Relevance 115.76 Pain Relevance 21.48

signal transduction (TNFSF10) extracellular space (TNFSF10) extracellular region (TNFSF10) cell-cell signaling (TNFSF10)

Anatomy Link Frequency T cells 20 fibroblasts 6 articular 6 macrophages 5 lymphocytes 4 TNFSF10 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 1090 100.00 spinal inflammation 44 99.80 Morphine 19 99.62 Arthritis 2125 99.52 cytokine 260 98.86 rheumatoid arthritis 677 98.84 cINOD 86 98.24 Chronic pancreatitis 11 97.12 Multiple sclerosis 44 90.80 cva 7 89.08

Disease Link Frequency Relevance Heat Apoptosis 4213 100.00 Cancer 2456 100.00 INFLAMMATION 1111 100.00 Death 975 100.00 Colon Cancer 641 100.00 Necrosis 152 100.00 Skin Cancer 11 99.88 Diabetes Mellitus 545 99.84 Autoimmune Disease 301 99.84 Low Back Pain 53 99.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These in vivo experimental results are consistent with our previous results using an adenoviral vector expressing TRAIL protein.

Gene_expression (expressing) of TRAIL

1) Confidence 0.75 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.90 Pain Relevance 0.15

Analysis of the purified rTRAIL protein demonstrated that both trimeric and dimeric TRAIL were present at a ratio of 4:1 [13] (data not shown).

Gene_expression (present) of TRAIL

2) Confidence 0.75 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.18 Pain Relevance 0.09

It appears as if the apoptotic effect of the over-expression of TRAIL on the synovial fibroblasts from RA patients is mediated predominantly by TRAIL R1 as its expression varied from patient to patient and the extent of apoptosis following TRAIL gene transfer seemed to correlate with its expression intensity (data not shown).

Gene_expression (transfer) of TRAIL in fibroblasts associated with rheumatoid arthritis and apoptosis

3) Confidence 0.75 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.76 Pain Relevance 0.13

It is possible that the proliferating rabbit synovium in vivo expresses higher levels of TRAIL receptors.

Gene_expression (expresses) of TRAIL in synovium

4) Confidence 0.75 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.81 Pain Relevance 0.11

Although these previous results suggest that gene transfer of TRAIL could be therapeutic to treat certain pathologies associated with RA, there currently is no appropriate gene transfer system that could be used clinically to deliver TRAIL intra-articularly.

Gene_expression (transfer) of TRAIL associated with rheumatoid arthritis

5) Confidence 0.75 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.19 Pain Relevance 0.15

It appears as if the apoptotic effect of the over-expression of TRAIL on the synovial fibroblasts from RA patients is mediated predominantly by TRAIL R1 as its expression varied from patient to patient and the extent of apoptosis following TRAIL gene transfer seemed to correlate with its expression intensity (data not shown).

Gene_expression (over) of TRAIL in fibroblasts associated with rheumatoid arthritis and apoptosis

6) Confidence 0.75 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.84 Pain Relevance 0.16

We did not observe any consistent pattern of expression of the TRAIL decoy receptors in the limited number of human synovial fibroblast cultures examined, suggesting that susceptibility to TRAIL is conferred through the level of expression of TRAIL R1 (data not shown).

Gene_expression (expression) of TRAIL in fibroblast

7) Confidence 0.75 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.83 Pain Relevance 0.14

The extent of apoptosis observed was similar to that observed following adenoviral gene transfer of TRAIL and FasL.

Gene_expression (transfer) of TRAIL associated with apoptosis

8) Confidence 0.75 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.90 Pain Relevance 0.05

In this study, we investigated the association between the expression of TRAIL and AS.

Gene_expression (expression) of TRAIL associated with spinal inflammation

9) Confidence 0.75 Published 2008 Journal J. Clin. Lab. Anal. Section Abstract Doc Link 18348311 Disease Relevance 1.53 Pain Relevance 0.68

The results indicated that the expression levels of TRAIL mRNA, and serum sTRAIL were significantly elevated in AS patients, compared with RA patients and healthy controls, and there was a close association between TRAIL mRNA and sTRAIL levels.

Gene_expression (expression) of TRAIL associated with spinal inflammation and rheumatoid arthritis

10) Confidence 0.75 Published 2008 Journal J. Clin. Lab. Anal. Section Abstract Doc Link 18348311 Disease Relevance 1.51 Pain Relevance 0.81

In conclusion, upregulated expression of TRAIL might be somewhat specific for evaluation of AS.

Gene_expression (expression) of TRAIL associated with spinal inflammation

11) Confidence 0.75 Published 2008 Journal J. Clin. Lab. Anal. Section Abstract Doc Link 18348311 Disease Relevance 1.16 Pain Relevance 0.73

OBJECTIVE: The present study investigated, through immunohistochemistry, the regional expression of TRAIL and in temporomandibular joint (TMJ) disc of anterior disc displacement with reduction (ADDwR) and without reduction (ADDwoR) patients, to help determine the relationship between TMJ disc displacement and apoptosis.

Spec (investigated) Gene_expression (expression) of TRAIL in anterior

12) Confidence 0.71 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20123409 Disease Relevance 0.09 Pain Relevance 0

CONCLUSIONS: TRAIL and DR5 are overexpressed in displaced human TMJ disc, especially in the posterior disc attachment.

Gene_expression (overexpressed) of TRAIL in TMJ

13) Confidence 0.71 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20123409 Disease Relevance 0.05 Pain Relevance 0

A human TRAIL cDNA fragment (corresponding to amino acids 114 to 281) obtained by PCR was cloned into the pET-23d (Novagen, Madison, WI, USA) plasmid, and expressed protein was purified using the His-band Resin and Buffer Kit (Novagen) [13].

Gene_expression (expressed) of TRAIL in band

14) Confidence 0.65 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.39 Pain Relevance 0.11

We did not observe any consistent pattern of expression of the TRAIL decoy receptors in the limited number of human synovial fibroblast cultures examined, suggesting that susceptibility to TRAIL is conferred through the level of expression of TRAIL R1 (data not shown).

Gene_expression (expression) of TRAIL in fibroblast

15) Confidence 0.65 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.80 Pain Relevance 0.14

It is possible that TRAIL reduces the leukocytic infiltrate through the direct induction of apoptosis of intra-articular leukocytes [21].

Gene_expression (reduces) of TRAIL in leukocytes associated with inflammation and apoptosis

16) Confidence 0.65 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.29 Pain Relevance 0.16

Our previous studies with adenoviral gene transfer of membrane bound TRAIL, however, showed that it too was relatively inefficient in inducing synovial apoptosis, requiring a high multiplicity of infection to confer apoptosis in culture.

Gene_expression (transfer) of TRAIL associated with apoptosis and infection

17) Confidence 0.65 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.92 Pain Relevance 0.05

Cell sensitivity to TRAIL can be affected by TRAIL-receptor expression at the cell membrane, DR4/DR5 ratio and functionality of TRAIL-receptors.

Gene_expression (expression) of TRAIL

18) Confidence 0.65 Published 2004 Journal Drug Resist. Updat. Section Abstract Doc Link 15790545 Disease Relevance 1.13 Pain Relevance 0.06

Isolated disk cells were analyzed by flow cytometry for Fas, FasL, TRAIL, DR4 and DR5 expression.

Spec (analyzed) Gene_expression (expression) of TRAIL

19) Confidence 0.65 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19305384 Disease Relevance 0.74 Pain Relevance 0.10

Expression of TRAIL and the death receptors DR4 and DR5 correlates with progression of degeneration in human intervertebral disks.

Gene_expression (Expression) of TRAIL associated with death

20) Confidence 0.65 Published 2009 Journal Mod. Pathol. Section Title Doc Link 19305384 Disease Relevance 0.77 Pain Relevance 0.13

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