INT11686

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Context Info
Confidence 0.45
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 8.69
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL3) extracellular region (IL3) cell-cell signaling (IL3)
Anatomy Link Frequency
CFU-GM 2
BFU-E 2
macrophage 1
leukocyte 1
bone marrow 1
IL3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 67 100.00 Very High Very High Very High
Inflammation 52 100.00 Very High Very High Very High
cva 4 100.00 Very High Very High Very High
Cholecystokinin 53 98.56 Very High Very High Very High
Paracetamol 2 76.44 Quite High
headache 11 72.28 Quite High
cINOD 3 62.88 Quite High
Pain 2 52.48 Quite High
Opioid 2 28.56 Quite Low
Neurotransmitter 1 18.72 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 53 100.00 Very High Very High Very High
Aplastic Anemia 3 99.84 Very High Very High Very High
Hypersensitivity 36 99.56 Very High Very High Very High
Myelodysplastic Syndromes 3 99.28 Very High Very High Very High
Hematological Disease 15 99.00 Very High Very High Very High
Heparin-induced Thrombocytopenia 4 98.84 Very High Very High Very High
Apoptosis 9 98.52 Very High Very High Very High
Death 2 97.92 Very High Very High Very High
Rhinitis 15 96.56 Very High Very High Very High
Lung Cancer 1 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of recombinant human interleukin-3 (rhIL-3) on persisting chemotherapy-induced thrombocytopenia.
Regulation (Effect) of rhIL-3 associated with heparin-induced thrombocytopenia and cva
1) Confidence 0.45 Published 1994 Journal Anticancer Drugs Section Title Doc Link 7949256 Disease Relevance 0.29 Pain Relevance 0.18
Effect of recombinant human interleukin-3 (rhIL-3) on persisting chemotherapy-induced thrombocytopenia.
Regulation (Effect) of interleukin-3 associated with heparin-induced thrombocytopenia and cva
2) Confidence 0.45 Published 1994 Journal Anticancer Drugs Section Title Doc Link 7949256 Disease Relevance 0.29 Pain Relevance 0.18
Effect of recombinant human interleukin-3 on haematological recovery from chemotherapy-induced myelosuppression.
Regulation (Effect) of interleukin-3
3) Confidence 0.45 Published 1994 Journal Br. J. Haematol. Section Title Doc Link 7986706 Disease Relevance 0.96 Pain Relevance 0.07
Effects of recombinant human interleukin-3 in patients with myelodysplastic syndromes.
Regulation (Effects) of interleukin-3 associated with myelodysplastic syndromes
4) Confidence 0.45 Published 1990 Journal Blood Section Title Doc Link 2378979 Disease Relevance 0.46 Pain Relevance 0.11
In contrast, both modes of cytokine therapy raised the platelet counts to the same degree. rhIL-3/GM-CSF treatment was more effective than rhIL-3 in increasing the number of circulating hematopoietic progenitor cells BFU-E and CFU-GM.
Regulation (effective) of rhIL-3 in BFU-E associated with cytokine
5) Confidence 0.45 Published 1992 Journal Blood Section Abstract Doc Link 1586711 Disease Relevance 0.77 Pain Relevance 0.16
In contrast, both modes of cytokine therapy raised the platelet counts to the same degree. rhIL-3/GM-CSF treatment was more effective than rhIL-3 in increasing the number of circulating hematopoietic progenitor cells BFU-E and CFU-GM.
Regulation (effective) of rhIL-3 in BFU-E associated with cytokine
6) Confidence 0.45 Published 1992 Journal Blood Section Abstract Doc Link 1586711 Disease Relevance 0.77 Pain Relevance 0.16
Both cytokines were administered by subcutaneous (SC) bolus injection. rhIL-3/rhGM-CSF treatment was more effective than rhIL-3 but equally effective to each other in increasing peripheral leukocyte counts, especially neutrophilic and eosinophilic granulocyte counts.
Regulation (effective) of rhIL-3 in leukocyte associated with rhinitis and cytokine
7) Confidence 0.45 Published 1992 Journal Blood Section Abstract Doc Link 1586711 Disease Relevance 0.42 Pain Relevance 0.09
Effects of recombinant human interleukin-3 in patients with normal hematopoiesis and in patients with bone marrow failure.
Regulation (Effects) of interleukin-3 in bone marrow associated with hematological disease
8) Confidence 0.45 Published 1990 Journal Blood Section Title Doc Link 2383650 Disease Relevance 0.45 Pain Relevance 0
Effects of recombinant human interleukin-3 in aplastic anemia.
Regulation (Effects) of interleukin-3 associated with aplastic anemia
9) Confidence 0.39 Published 1990 Journal Blood Section Title Doc Link 2207306 Disease Relevance 0.58 Pain Relevance 0.06
Haematopoietic cytokines such as IL-3, IL-5 and GM-CSF not only activate eosinophils but also prolong their life span by inhibiting their apoptotic cell death.
Regulation (prolong) of IL-3 in apoptotic cell associated with apoptosis, death and cytokine
10) Confidence 0.25 Published 1999 Journal Immunol. Invest. Section Abstract Doc Link 10574634 Disease Relevance 0.51 Pain Relevance 0.28
In contrast, both modes of cytokine therapy raised the platelet counts to the same degree. rhIL-3/GM-CSF treatment was more effective than rhIL-3 in increasing the number of circulating hematopoietic progenitor cells BFU-E and CFU-GM.
Regulation (effective) of rhIL-3 in CFU-GM associated with cytokine
11) Confidence 0.15 Published 1992 Journal Blood Section Abstract Doc Link 1586711 Disease Relevance 0.77 Pain Relevance 0.16
In contrast, both modes of cytokine therapy raised the platelet counts to the same degree. rhIL-3/GM-CSF treatment was more effective than rhIL-3 in increasing the number of circulating hematopoietic progenitor cells BFU-E and CFU-GM.
Regulation (effective) of rhIL-3 in CFU-GM associated with cytokine
12) Confidence 0.15 Published 1992 Journal Blood Section Abstract Doc Link 1586711 Disease Relevance 0.77 Pain Relevance 0.16
It contains two modified phosphorothioate anti-sense oligonucleotides designed to inhibit allergic inflammation by down-regulating human CCR3 and the common beta-chain of IL-3, IL-5 and GM CSF.
Regulation (regulating) of IL-3 associated with inflammation and hypersensitivity
13) Confidence 0.10 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.71 Pain Relevance 0.05
In a mouse model, McDermott and colleagues [29] demonstrated that upper gut inflammation, via specific control of CD4+ T lymphocytes and related inflammatory cytokines (interleukin-3 and interleukin-4), can upregulate CCK-expressing cells, increase plasma CCK concentrations, and reduce energy intake.
Regulation (control) of interleukin-3 in T lymphocytes associated with inflammation, cholecystokinin and cytokine
14) Confidence 0.04 Published 2006 Journal Crit Care Section Body Doc Link PMC1794491 Disease Relevance 0.84 Pain Relevance 0.67
The p38 MAPK pathway has been shown to affect the mRNA stability of proinflammatory genes, mainly that of mRNA for cytokines such as IL-2, IL-3, IL-6, IL-8, TNF, and GM-CSF [90-92] but also that of mRNA for cyclo-oxygenase 2 (COX-2) [93], vascular endothelial growth factor (VEGF) [94], macrophage inflammatory protein 2 (MIP-2) [91], urokinase-type plasminogen activator (uPAR) [95], and MKK6 [96].
Regulation (affect) of IL-3 in macrophage associated with inflammation and cytokine
15) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.09 Pain Relevance 0.21

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