INT116861

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2011
Negated 4
Speculated 4
Reported most in Body
Documents 182
Total Number 191
Disease Relevance 100.41
Pain Relevance 27.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
brain 9
macrophages 8
neurons 7
astrocyte 5
microglia 4
Apoe (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1699 100.00 Very High Very High Very High
cytokine 722 100.00 Very High Very High Very High
Neuritis 519 100.00 Very High Very High Very High
antagonist 63 100.00 Very High Very High Very High
Abeta 8 100.00 Very High Very High Very High
chemokine 97 99.76 Very High Very High Very High
cINOD 1417 99.74 Very High Very High Very High
withdrawal 297 99.64 Very High Very High Very High
dexamethasone 2578 99.58 Very High Very High Very High
Multiple sclerosis 289 99.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1996 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 1560 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 519 100.00 Very High Very High Very High
Adhesions 308 100.00 Very High Very High Very High
Infection 178 100.00 Very High Very High Very High
Atherosclerotic Plaque 140 100.00 Very High Very High Very High
Sprains And Strains 64 100.00 Very High Very High Very High
Disease 6178 99.92 Very High Very High Very High
Atherosclerosis 971 99.92 Very High Very High Very High
Targeted Disruption 2664 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As there is limited permeability of the BBB to lipoproteins [14, 128, 129], this change might be due to a decrease of local apoE synthesis and secretion by brain tissue, as part of systemic decrease of apoE synthesis in acute phage reaction [4].
Gene_expression (synthesis) of apoE in brain
1) Confidence 0.78 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.71 Pain Relevance 0.13
ApoE is synthesized predominantly in the liver, but also by cells in the spleen, brain, lung, kidney, ovary, adrenal, and muscle tissues.
Gene_expression (synthesized) of ApoE in lung
2) Confidence 0.78 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.41 Pain Relevance 0.13
As reported by a variety of studies, apoE produced by mammalian cells exists in different forms, monomers, dimers, modified, unmodified, lipid-rich, and lipid-poor, and so forth [9–13].
Gene_expression (produced) of apoE
3) Confidence 0.78 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.44 Pain Relevance 0.06
As there is limited permeability of the BBB to lipoproteins [14, 128, 129], this change might be due to a decrease of local apoE synthesis and secretion by brain tissue, as part of systemic decrease of apoE synthesis in acute phage reaction [4].
Gene_expression (synthesis) of apoE in brain
4) Confidence 0.78 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.76 Pain Relevance 0.12
The next series of experiments used primary cultures derived from transgenic mice that express apoE3 or apo4 under the glial fibrillary acidic protein promoter.
Gene_expression (express) of apoE3 associated with targeted disruption
5) Confidence 0.78 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0.33 Pain Relevance 0.07
One of the most profound implications of the production of soluble apoE receptors is the possible dominant negative effect on apoE receptor function.
Gene_expression (production) of apoE
6) Confidence 0.76 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.10 Pain Relevance 0.03
In humans, decreased expression of apoE caused by some types of genetic disease (Type III hyperlipoproteinaemia associated with familial apolipoprotein E deficiency) leads to an altered lipid profile and an increase in the prevalence of atherosclerosis in these patients [26, 27].
Gene_expression (expression) of apoE associated with atherosclerosis, hyperlipidemia, disease and disorder of lipid metabolism
7) Confidence 0.75 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2975993 Disease Relevance 0.90 Pain Relevance 0.04
One may raise the issue that apoE-HDL/EM internalization via several apoE receptors expressed on neurons and recycled-apoE-mediated cholesterol efflux may explain apoE-isoform-dependent cholesterol efflux induced by apoE-HDL/EM.
Gene_expression (expressed) of apoE in neurons associated with disorder of lipid metabolism
8) Confidence 0.74 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.77 Pain Relevance 0
In brain, apoE is mainly synthesized and secreted by astrocytes and microglia (Boyles et al., 1985).
Gene_expression (synthesized) of apoE in microglia
9) Confidence 0.71 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912027 Disease Relevance 0.61 Pain Relevance 0.28
Hepatic parenchyma cells are the main apoE producing cells in mammalian body, probably accounting for two thirds to three fourths of the plasma apoE [5].
Gene_expression (producing) of apoE in Hepatic parenchyma
10) Confidence 0.68 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.37 Pain Relevance 0.11
Using these same transgenic mice aged 1 to 2 years, a final in vivo study demonstrated greater spine density in transgenic mice expressing human apoE3 than human apoE4 [59].
Gene_expression (expressing) of apoE4 in spine associated with targeted disruption
11) Confidence 0.68 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0.41 Pain Relevance 0.07
Using these same transgenic mice aged 1 to 2 years, a final in vivo study demonstrated greater spine density in transgenic mice expressing human apoE3 than human apoE4 [59].
Gene_expression (expressing) of apoE3 in spine associated with targeted disruption
12) Confidence 0.68 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0.41 Pain Relevance 0.07
In addition, apoE deficiency results in elevated autoimmune activity in mice, which can be detected as early as 7 weeks of age, and might explain the susceptibility of deficient mice to either EAN or EAE [119].
Gene_expression (deficiency) of apoE associated with multiple sclerosis and neuritis
13) Confidence 0.67 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.51 Pain Relevance 0.14
Also of note is that apoE levels in the CNS vary during the estrous cycle and estrogen could increase ApoE levels [76, 167–169].
Gene_expression (levels) of apoE
14) Confidence 0.67 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.30 Pain Relevance 0.09
The difference might either be due to the increased susceptibility to proinflammatory stimulation, resulting in the high expression of MHC class II molecules and costimulatory molecules on innate immune cells like macrophages, or be due to tendency to Th1 cytokine production in apoE-deficient mice.
Gene_expression (production) of apoE in macrophages associated with cytokine
15) Confidence 0.67 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.29 Pain Relevance 0.18
Increased CC chemokine receptor 3 expression on microglia in apoE-deficient mice after KA administration appeared to facilitate the microglial recruitment and accumulation in the injured areas [90].
Gene_expression (expression) of apoE in microglia associated with chemokine
16) Confidence 0.67 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.34 Pain Relevance 0.05
A series of studies demonstrated both apoE containing lipoproteins and multimers of synthetic apoE peptides inhibited proliferation of cultured lymphocytes by inhibiting DNA synthesis and reducing phospholipid turnover in T cells [26, 45–48].
Gene_expression (containing) of apoE in T cells
17) Confidence 0.67 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.59 Pain Relevance 0.16
A variety of studies demonstrated an isoform-specific effect of apoE on macrophage functions, including NO production and cytokine secretion [28, 30, 79].
Gene_expression (effect) of apoE in macrophage associated with cytokine
18) Confidence 0.67 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.82 Pain Relevance 0.79
Again, these showed greater relative neurotrophism of apoE3 expression compared to apoE4 that was largely LRP-dependent [57,58].
Gene_expression (expression) of apoE3
19) Confidence 0.67 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0.39 Pain Relevance 0.07
While apoE isoform-specific interactions with A?
Gene_expression (isoform) of apoE
20) Confidence 0.67 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 1.18 Pain Relevance 0.06

General Comments

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