INT116879

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 22
Disease Relevance 5.82
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (MAGEA4) cellular_component (MAGEA4) biological_process (MAGEA4)
Anatomy Link Frequency
germ cells 15
testes 1
SCP 1
MAGEA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 10 95.64 Very High Very High Very High
analgesia 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Testicular Cancer 60 100.00 Very High Very High Very High
Cancer 22 99.70 Very High Very High Very High
Pancreatic Cancer 10 99.36 Very High Very High Very High
Adenocarcinoma 4 96.28 Very High Very High Very High
Pancreatitis 10 95.64 Very High Very High Very High
Carcinoma In Situ 80 95.22 Very High Very High Very High
Congenital Anomalies 100 89.52 High High
Syndrome 220 88.64 High High
Malignant Neoplastic Disease 22 87.32 High High
Cryptorchidism 20 84.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to define antigens that might be suitable as vaccines for pancreatic carcinoma, we investigated the composite expression of 10 cancer testis (CT) antigens (SCP-1, NY-ESO-1, SSX-1, SSX-2, SSX-4, GAGE, MAGE-3, MAGE-4, CT-7 and CT-8) by Reverse Transcriptase-PCR (RT-PCR) in fresh biopsies of human pancreatic adenocarcinoma, chronic pancreatitis and pancreatic carcinoma cell lines.
Gene_expression (expression) of MAGE-4 in SCP associated with adenocarcinoma, pancreatic cancer, testicular cancer and chronic pancreatitis
1) Confidence 0.41 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14991579 Disease Relevance 1.53 Pain Relevance 0.17
While all CT genes were frequently expressed in cell lines derived from pancreatic cancer, no expression of MAGE-3, SSX-1, SSX-2, NY-ESO-1 and CT-7 was detected in fresh tumor biopsies, and MAGE-4 (1/52), SSX-4 (1/39) and CT-8 (2/41) were only rarely expressed.
Gene_expression (expressed) of MAGE-4 associated with cancer, pancreatic cancer and testicular cancer
2) Confidence 0.28 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14991579 Disease Relevance 1.84 Pain Relevance 0.30
The gonocyte pluripotency marker OCT4 was expressed in most germ cells of first trimester testes prior to grafting, while after grafting some of the germ cells had ceased to express this protein, coincident with emerging expression of proteins associated with differentiation into pre-spermatogonia, such as MAGE-A4 and VASA (Fig. 4A).
Gene_expression (express) of MAGE-A4 in testes
3) Confidence 0.20 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0.06 Pain Relevance 0
Examples of proliferating germ cells expressing OCT4+/MAGE-A4?
Gene_expression (expressing) of MAGE-A4 in germ cells
4) Confidence 0.20 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
germ cells (i.e. undifferentiated) had the highest PI, while the subpopulations that expressed MAGE-A4 (i.e. differentiated) had a lower PI.
Gene_expression (expressed) of MAGE-A4 in germ cells
5) Confidence 0.20 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
(white arrows), OCT4+/MAGE-A4+ (white arrowheads) and OCT4?
Gene_expression (/) of MAGE-A4
6) Confidence 0.18 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
Quantification of the proliferation index (PI) for the different germ cell subpopulations showed that OCT4+/MAGE-A4?
Gene_expression (showed) of MAGE-A4 in germ cell
7) Confidence 0.18 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
The present study has shown that germ cell differentiation from gonocyte (OCT4+/MAGE-A4?
Gene_expression (/) of MAGE-A4 in germ cell
8) Confidence 0.18 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
(white arrows), OCT4+/MAGE-A4+ (white arrowheads) and OCT4?
Gene_expression (arrows) of MAGE-A4
9) Confidence 0.18 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
This demonstrated that a proportion of all three subpopulations of germ cells (OCT4+/MAGE-A4?
Gene_expression (/) of MAGE-A4 in germ cells
10) Confidence 0.18 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
(white arrows), OCT4+/MAGE-A4+ (white arrowheads) and OCT4?
Gene_expression (arrowheads) of MAGE-A4
11) Confidence 0.18 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
Quantification of the proliferation index (PI) for the different germ cell subpopulations showed that OCT4+/MAGE-A4?
Gene_expression (/) of MAGE-A4 in germ cell
12) Confidence 0.18 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
The present study has shown that germ cell differentiation from gonocyte (OCT4+/MAGE-A4?
Gene_expression (gonocyte) of MAGE-A4 in germ cell
13) Confidence 0.18 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
Examples of proliferating germ cells expressing OCT4+/MAGE-A4?
Gene_expression (expressing) of MAGE-A4 in germ cells
14) Confidence 0.18 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
This demonstrated that a proportion of all three subpopulations of germ cells (OCT4+/MAGE-A4?
Gene_expression (germ cells) of MAGE-A4 in germ cells
15) Confidence 0.18 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
, OCT4+/MAGE-A4+ and OCT4?
Gene_expression (/) of MAGE-A4
16) Confidence 0.15 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
Figure 5(A) Proliferation (Ki67, green) of germ cell subpopulations in a second trimester human fetal testis xenograft based on co-immunoexpression with either OCT4 (red), or MAGE-A4 (blue).
Gene_expression (immunoexpression) of MAGE-A4 in germ cell
17) Confidence 0.15 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
However, this could not account for the emergence of differentiated (VASA+ or MAGE-A4+) germ cells in first-trimester grafts compared with pre-graft controls (most of which had no VASA or MAGE-A4 expressing cells prior to grafting) or for the increase in proportion of differentiated germ cells in the second-trimester grafts.
Neg (no) Gene_expression (expressing) of MAGE-A4 in germ cells
18) Confidence 0.15 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0.11 Pain Relevance 0
Note that after grafting, the proportion of germ cells expressing OCT4 decreases as demonstrated by the presence of unstained germ cells (arrowhead), compared with the pre-graft control, whereas expression of MAGE-A4 and VASA (arrows, inset) increase (neither are expressed in the pre-graft control).
Gene_expression (expression) of MAGE-A4 in germ cells
19) Confidence 0.14 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
CIS cells are thought to originate because of failure of normal differentiation of fetal germ cells into prespermatogonia (Rajpert-De Meyts, 2006), a process that encompasses fetal and early post-natal life in humans and involves the loss of expression of pluripotency factors (OCT4 and NANOG) and expression of proteins indicative of differentiation (VASA and MAGE-A4) (Gaskell et al., 2004; Anderson et al., 2007; Mitchell et al., 2008).
Gene_expression (expression) of MAGE-A4 in germ cells associated with carcinoma in situ
20) Confidence 0.14 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 1.15 Pain Relevance 0

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