INT116880

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Context Info
Confidence 0.73
First Reported 2004
Last Reported 2006
Negated 1
Speculated 1
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 13.37
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (SYCP1) nucleus (SYCP1) cell cycle (SYCP1)
DNA binding (SYCP1) cell division (SYCP1)
Anatomy Link Frequency
SCP 7
testis 1
SYCP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 32 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Testicular Cancer 74 100.00 Very High Very High Very High
Pancreatic Cancer 40 99.60 Very High Very High Very High
Cancer 22 99.36 Very High Very High Very High
Pancreatitis 32 99.24 Very High Very High Very High
Malignant Neoplastic Disease 6 97.60 Very High Very High Very High
Adenocarcinoma 12 94.16 High High
Immunotherapy Of Cancer 2 85.92 High High
Metastasis 2 69.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to define antigens that might be suitable as vaccines for pancreatic carcinoma, we investigated the composite expression of 10 cancer testis (CT) antigens (SCP-1, NY-ESO-1, SSX-1, SSX-2, SSX-4, GAGE, MAGE-3, MAGE-4, CT-7 and CT-8) by Reverse Transcriptase-PCR (RT-PCR) in fresh biopsies of human pancreatic adenocarcinoma, chronic pancreatitis and pancreatic carcinoma cell lines.
Spec (investigated) Gene_expression (expression) of SCP-1 in SCP associated with adenocarcinoma, pancreatic cancer, testicular cancer and chronic pancreatitis
1) Confidence 0.73 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14991579 Disease Relevance 1.49 Pain Relevance 0.17
SCP-1 protein expression correlated well with mRNA expression.
Gene_expression (expression) of SCP-1 in SCP
2) Confidence 0.73 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14991579 Disease Relevance 1.76 Pain Relevance 0.39
In contrast, HOM-TES-14/SCP-1 was expressed in 48% (29/61) and GAGE in 21% (13/61) of cases, respectively.
Gene_expression (expressed) of SCP-1 in SCP
3) Confidence 0.73 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14991579 Disease Relevance 1.80 Pain Relevance 0.35
Whether SCP-1 and GAGE expression identify cases of chronic pancreatitis with a high risk of malignant transformation remains to be shown.
Gene_expression (expression) of SCP-1 in SCP associated with malignant neoplastic disease and chronic pancreatitis
4) Confidence 0.73 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14991579 Disease Relevance 1.76 Pain Relevance 0.42
Therefore, we investigated the IgG antibody response against 11 cancer testis antigens (SCP-1, GAGE, LAGE-1a,-1b, CT-7, NY-ESO-1, SSX-1-5) recombinantly expressed on yeast surface (RAYS) in patients with pancreatic cancer (n = 96), chronic pancreatitis (n = 18) and healthy donors (n = 48).
Gene_expression (expressed) of SCP-1 in testis associated with pancreatic cancer, testicular cancer and chronic pancreatitis
5) Confidence 0.62 Published 2006 Journal Int. J. Cancer Section Abstract Doc Link 16432832 Disease Relevance 1.41 Pain Relevance 0.10
Antibody response correlated with the expression of SCP-1 in the primary tumor of the respective patient as shown by RT-PCR, immunohistochemistry and Western blot.
Gene_expression (expression) of SCP-1 in SCP associated with cancer
6) Confidence 0.62 Published 2006 Journal Int. J. Cancer Section Abstract Doc Link 16432832 Disease Relevance 1.59 Pain Relevance 0.09
In contrast, HOM-TES-14/SCP-1 was expressed in 48% (29/61) and GAGE in 21% (13/61) of cases, respectively.
Gene_expression (expressed) of HOM-TES-14 in SCP
7) Confidence 0.56 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14991579 Disease Relevance 1.81 Pain Relevance 0.35
While SCP-1 and GAGE were absent in normal pancreas, they were found in 2/8 (SCP-1) and 1/8 (GAGE) samples of chronic pancreatitis, respectively, supporting the concept of chronic pancreatitis as a premalignant condition.
Neg (absent) Gene_expression (absent) of SCP-1 in SCP associated with chronic pancreatitis
8) Confidence 0.56 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14991579 Disease Relevance 1.74 Pain Relevance 0.42

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