INT116882

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 10.64
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
testis 3
ovary 2
SCP 1
CTAG1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 11 97.20 Very High Very High Very High
cytokine 48 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
positron emission tomography 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Testicular Cancer 27 100.00 Very High Very High Very High
Pancreatic Cancer 15 99.90 Very High Very High Very High
Cancer 366 99.32 Very High Very High Very High
Pancreatitis 11 97.20 Very High Very High Very High
Skin Cancer 28 97.04 Very High Very High Very High
Adenocarcinoma 4 94.56 High High
Immunotherapy Of Cancer 5 84.64 Quite High
Malignant Neoplastic Disease 10 84.56 Quite High
Disease 64 73.44 Quite High
Sprains And Strains 4 65.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While all CT genes were frequently expressed in cell lines derived from pancreatic cancer, no expression of MAGE-3, SSX-1, SSX-2, NY-ESO-1 and CT-7 was detected in fresh tumor biopsies, and MAGE-4 (1/52), SSX-4 (1/39) and CT-8 (2/41) were only rarely expressed.
Gene_expression (expression) of NY-ESO-1 associated with cancer, pancreatic cancer and testicular cancer
1) Confidence 0.45 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14991579 Disease Relevance 1.78 Pain Relevance 0.28
In order to define antigens that might be suitable as vaccines for pancreatic carcinoma, we investigated the composite expression of 10 cancer testis (CT) antigens (SCP-1, NY-ESO-1, SSX-1, SSX-2, SSX-4, GAGE, MAGE-3, MAGE-4, CT-7 and CT-8) by Reverse Transcriptase-PCR (RT-PCR) in fresh biopsies of human pancreatic adenocarcinoma, chronic pancreatitis and pancreatic carcinoma cell lines.
Spec (investigated) Gene_expression (expression) of NY-ESO-1 in SCP associated with adenocarcinoma, pancreatic cancer, testicular cancer and chronic pancreatitis
2) Confidence 0.45 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14991579 Disease Relevance 1.50 Pain Relevance 0.17
Therefore, we investigated the IgG antibody response against 11 cancer testis antigens (SCP-1, GAGE, LAGE-1a,-1b, CT-7, NY-ESO-1, SSX-1-5) recombinantly expressed on yeast surface (RAYS) in patients with pancreatic cancer (n = 96), chronic pancreatitis (n = 18) and healthy donors (n = 48).
Gene_expression (expressed) of NY-ESO-1 in testis associated with pancreatic cancer, testicular cancer and chronic pancreatitis
3) Confidence 0.29 Published 2006 Journal Int. J. Cancer Section Abstract Doc Link 16432832 Disease Relevance 1.40 Pain Relevance 0.10
Antigen from NY-ESO-1, a gene expressed in normal ovary and testis, is highly expressed in a variety of tumor types [59], including HNSCC [60].
Gene_expression (expressed) of NY-ESO-1 in ovary associated with cancer
4) Confidence 0.10 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2723756 Disease Relevance 1.51 Pain Relevance 0
Antigen from NY-ESO-1, a gene expressed in normal ovary and testis, is highly expressed in a variety of tumor types [59], including HNSCC [60].
Gene_expression (expressed) of NY-ESO-1 in ovary associated with cancer
5) Confidence 0.10 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2723756 Disease Relevance 1.47 Pain Relevance 0
Antigen from NY-ESO-1, a gene expressed in normal ovary and testis, is highly expressed in a variety of tumor types [59], including HNSCC [60].
Gene_expression (expressed) of NY-ESO-1 in testis associated with cancer
6) Confidence 0.03 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2723756 Disease Relevance 1.51 Pain Relevance 0
Antigen from NY-ESO-1, a gene expressed in normal ovary and testis, is highly expressed in a variety of tumor types [59], including HNSCC [60].
Gene_expression (expressed) of NY-ESO-1 in testis associated with cancer
7) Confidence 0.03 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2723756 Disease Relevance 1.47 Pain Relevance 0

General Comments

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