INT11689

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 2.77
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (PSMD2) cytosol (PSMD2) nucleoplasm (PSMD2)
small molecule metabolic process (PSMD2) cellular nitrogen compound metabolic process (PSMD2)
Anatomy Link Frequency
internal 1
parasympathetic 1
PSMD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 6 79.12 Quite High
Pain 23 75.32 Quite High
cva 3 73.04 Quite High
nud 1 71.20 Quite High
Paracetamol 8 59.04 Quite High
headache 3 35.28 Quite Low
Calcium channel 1 34.52 Quite Low
abdominal pain 1 34.48 Quite Low
sodium channel 10 31.60 Quite Low
ischemia 6 23.84 Low Low
Disease Link Frequency Relevance Heat
Post-exercise Hypotension 18 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 99.98 Very High Very High Very High
Stress 111 93.36 High High
Infection 52 92.56 High High
Sprains And Strains 30 91.24 High High
Coccidioides Infection 17 89.80 High High
Cardiovascular Disease 70 77.64 Quite High
Pain 25 75.32 Quite High
Gingival Hemorrhage 1 73.04 Quite High
Nose Bleeds 3 72.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The sensation of rectal distension travels with the parasympathetic system to S2, S3 and S4.
S2 Binding (travels) of in parasympathetic
1) Confidence 0.36 Published 1992 Journal Baillieres Clin. Gastroenterol. Section Abstract Doc Link 1586768 Disease Relevance 0.21 Pain Relevance 0.17
When relaxation was hyperactive, decreasing T less than 65% of control, S2 intensity was increased.
S2 Binding (intensity) of
2) Confidence 0.32 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2531180 Disease Relevance 0.10 Pain Relevance 0
Several scenarios can occur for S2 amplitude. 1 – With constant ventricular relaxation rate, S2 amplitude is directly related to the diastolic aortic pressure: 2 – With constant aortic diastolic pressure, S2 amplitude is directly related to the ventricular relaxation rate.
S2 Binding (occur) of
3) Confidence 0.32 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2531180 Disease Relevance 0.14 Pain Relevance 0
Crosstabs' statistics and measures of association for post exercise hypotension vs. post exercise S2 amplitude undershoot were performed in 75 selected patients.


S2 Binding (association) of associated with post-exercise hypotension
4) Confidence 0.30 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2531180 Disease Relevance 0.57 Pain Relevance 0
Consider three associated SNPs, S1, S2, and S3, each with two alleles denoted by 1 and 0.
S2 Binding (associated) of
5) Confidence 0.17 Published 2008 Journal Mol Pain Section Body Doc Link PMC2422840 Disease Relevance 0 Pain Relevance 0
Nevertheless, animals in the vicinity of S1, S2, and S3, were found to be infected (5/7, 5/8, and 3/10 animals, respectively).
S2 Binding (vicinity) of
6) Confidence 0.08 Published 2007 Journal Emerging Infectious Diseases Section Body Doc Link PMC2878230 Disease Relevance 1.18 Pain Relevance 0.04
Importantly, the docked pose also suggested that one of the ligand rings binds in a previously uncharacterized, druggable pocket immediately beyond the S2 subsite (Figure 3).


S2 subsite Binding (binds) of
7) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2867933 Disease Relevance 0 Pain Relevance 0
The cruzain S2 subsite, like that of cathepsin B, differs from other cysteine proteases in that it can bind both hydrophobic and basic amino acids [2], [53].
S2 subsite Binding (bind) of
8) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2867933 Disease Relevance 0 Pain Relevance 0
The S2 subsite, critical for specificity, is an important exception; this site, like the S2 subsite of cathepsin B, differs from other cysteine proteases in that it can bind both hydrophobic and basic amino acids [2], [53].
S2 subsite Binding (bind) of
9) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2867933 Disease Relevance 0.07 Pain Relevance 0.06
Four subsites on the acyl side of the cleaved peptide bond, named S4, S3, S2, and S1, bind the peptide amino acids P4, P3, P2, and P1.
S2 Binding (bind) of
10) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2867933 Disease Relevance 0 Pain Relevance 0
When a basic amino acid like arginine occupies the S2 subsite, the acidic E205 carboxylate group swings into S2 to interact with the guanidino group, a conformation that can be seen in the crystal structure of cruzain bound to benzoyl-arginine-alanine-methyl ketone (PDB: 2AIM) [2], [53].
S2 Binding (interact) of
11) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2867933 Disease Relevance 0 Pain Relevance 0
When a basic amino acid like arginine occupies the S2 subsite, the acidic E205 carboxylate group swings into S2 to interact with the guanidino group, a conformation that can be seen in the crystal structure of cruzain bound to benzoyl-arginine-alanine-methyl ketone (PDB: 2AIM) [2], [53].
S2 Binding (bound) of
12) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2867933 Disease Relevance 0 Pain Relevance 0
When a basic amino acid like arginine occupies the S2 subsite, the acidic E205 carboxylate group swings into S2 to interact with the guanidino group, a conformation that can be seen in the crystal structure of cruzain bound to benzoyl-arginine-alanine-methyl ketone (PDB: 2AIM) [2], [53].
S2 subsite Binding (occupies) of
13) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2867933 Disease Relevance 0 Pain Relevance 0
When a basic amino acid like arginine occupies the S2 subsite, the acidic E205 carboxylate group swings into S2 to interact with the guanidino group, a conformation that can be seen in the crystal structure of cruzain bound to benzoyl-arginine-alanine-methyl ketone (PDB: 2AIM) [2], [53].
S2 subsite Binding (bound) of
14) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2867933 Disease Relevance 0 Pain Relevance 0
For quantitative traits (Figure S2), combining both cohorts provides a power of 75% for detecting a 0.3 standard deviation difference at allele frequency of 0.2 in men at p?
S2 Binding (combining) of
15) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 0.41 Pain Relevance 0
It has been suggested that: (i) voltage-gating domains have a large amount of internal flexibility compared with the pore domains, (ii) the V-paddle is situated on the periphery of the V-domain with some cationic sidechains interacting with anionic elements of adjacent subunits S1, S2 and S3; (iii) S2 and S3 are situated more proximal than V-paddle to the P-domain, and (iv) some S4 arginine residues interact in a critical fashion with the lipid membrane [2], [4], [16], [17], [18], [19], [20].
S2 Binding (interacting) of in internal
16) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2766034 Disease Relevance 0 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox