INT116892

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Context Info
Confidence 0.00
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.10
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Phax) transport (TRPV1) cytoplasm (Phax)
lipid metabolic process (TRPV1) cytosol (TRPV1) RNA binding (Phax)
Anatomy Link Frequency
TM3 2
TRPV1 (Homo sapiens)
Phax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 13 100.00 Very High Very High Very High
antagonist 10 100.00 Very High Very High Very High
agonist 21 89.96 High High
Analgesic 1 87.92 High High
Pain 4 84.72 Quite High
nociceptor 1 83.96 Quite High
Nicotine 16 68.24 Quite High
Glutamate 28 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Acupuncture 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sensation Disorders 2 96.24 Very High Very High Very High
Targeted Disruption 14 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low
Taste Disorders 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Blister 1 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To identify the structural features responsible for this difference in affinity, [(3)H]RTX binding to chimeras between hTRPV1 and rTRPV1 was characterized.
hTRPV1 Binding (binding) of RTX
1) Confidence 0.00 Published 2004 Journal Biochemistry Section Abstract Doc Link 14992587 Disease Relevance 0 Pain Relevance 0.61
Based on our data we propose a model of the TM3/4 region of TRPV1 bound to capsaicin or RTX that may aid in the development of potent TRPV1 antagonists with utility in the treatment of sensory disorders.
TRPV1 Binding (bound) of RTX in TM3 associated with qutenza, antagonist and sensation disorders
2) Confidence 0.02 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14996838 Disease Relevance 0.10 Pain Relevance 0.25
Here we identify key residues (Met(547) and Thr(550)) in transmembrane regions 3 and 4 (TM3/4) of rat and human TRPV1 that confer vanilloid sensitivity, [(3)H]RTX binding and competitive antagonist binding to rabbit TRPV1.
TRPV1 Binding (binding) of RTX in TM3 associated with antagonist
3) Confidence 0.01 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14996838 Disease Relevance 0 Pain Relevance 0.28
These results suggest that the binding of RTX or CAP to an intracellular-binding site on the TRPV1t alters the conformation of the channel and sensitizes the channel to further stimulation by GalA-MRP.
TRPV1t Binding (binding) of RTX
4) Confidence 0.01 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0 Pain Relevance 0.10

General Comments

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