INT1169

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2010
Negated 2
Speculated 7
Reported most in Abstract
Documents 322
Total Number 330
Disease Relevance 149.22
Pain Relevance 61.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Bche) endoplasmic reticulum (Bche)
Anatomy Link Frequency
plasma 16
brain 15
nerve 12
blood 7
muscle 5
Bche (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 216 100.00 Very High Very High Very High
antagonist 179 100.00 Very High Very High Very High
Pain 161 100.00 Very High Very High Very High
cerebral cortex 52 100.00 Very High Very High Very High
abdominal pain 13 100.00 Very High Very High Very High
intrathecal 171 99.98 Very High Very High Very High
anesthesia 98 99.98 Very High Very High Very High
agonist 196 99.92 Very High Very High Very High
headache 40 99.92 Very High Very High Very High
adenocard 99 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 262 100.00 Very High Very High Very High
Pain 151 100.00 Very High Very High Very High
Diarrhoea 150 100.00 Very High Very High Very High
Vomiting 129 100.00 Very High Very High Very High
Dizziness 80 100.00 Very High Very High Very High
Abdominal Pain 13 100.00 Very High Very High Very High
Disease 2375 99.96 Very High Very High Very High
Anxiety Disorder 91 99.96 Very High Very High Very High
Cognitive Disorder 1412 99.92 Very High Very High Very High
Delirium 68 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cholinesterase activity was inhibited in a dose-dependent manner in brain and plasma after administration of the organophosphates and CTA was correlated with the degree of plasma cholinesterase inhibition.
Negative_regulation (inhibition) of cholinesterase in plasma associated with appetite loss
1) Confidence 0.59 Published 1986 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 3703907 Disease Relevance 0.78 Pain Relevance 0.14
Cholinesterase activity was inhibited in a dose-dependent manner in brain and plasma after administration of the organophosphates and CTA was correlated with the degree of plasma cholinesterase inhibition.
Negative_regulation (inhibited) of Cholinesterase in plasma associated with appetite loss
2) Confidence 0.59 Published 1986 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 3703907 Disease Relevance 0.81 Pain Relevance 0.14
CONCLUSIONS: Donepezil, a well-tolerated cholinesterase inhibitor used in the treatment of Alzheimer dementia, reduces hypersensitivity in this rat model of neuropathic pain by actions on muscarinic receptors in the spinal cord.
Negative_regulation (inhibitor) of cholinesterase in spinal cord
3) Confidence 0.59 Published 2007 Journal Anesthesiology Section Body Doc Link 17457135 Disease Relevance 0.11 Pain Relevance 0
Lack of tolerance to this effect, in contrast to rapid tolerance to direct receptor agonists, suggests that cholinesterase inhibition may be useful in the treatment of neuropathic pain.


Negative_regulation (inhibition) of cholinesterase
4) Confidence 0.59 Published 2007 Journal Anesthesiology Section Body Doc Link 17457135 Disease Relevance 0 Pain Relevance 0
Activity of blood cholinesterase was reduced in young and mature rats at 30 and 60 min following carbaryl exposure.
Negative_regulation (reduced) of blood cholinesterase in blood
5) Confidence 0.59 Published 1991 Journal Neurotoxicol Teratol Section Abstract Doc Link 1904531 Disease Relevance 0.18 Pain Relevance 0
These results indicate that carbaryl can induce an age-related impairment on some behavioral and autonomic functions in rats correlated to the inhibition of cholinesterase activity.
Negative_regulation (inhibition) of cholinesterase in autonomic
6) Confidence 0.59 Published 1991 Journal Neurotoxicol Teratol Section Abstract Doc Link 1904531 Disease Relevance 0.16 Pain Relevance 0
The results suggest that DMSO enhances the slow ventral root potential through mechanisms based on the inhibition of cholinesterase activity and other action(s) involved in increasing transmitter release from nerve endings in nociceptive transmission pathways in the isolated spinal cord of the newborn rat.
Negative_regulation (inhibition) of cholinesterase in nerve associated with nociception and spinal cord
7) Confidence 0.59 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9687000 Disease Relevance 0.22 Pain Relevance 0.35
The purpose of the present work was to verify the effect of pyridostigmine bromide, a reversible cholinesterase inhibitor, on the increases in cardiac work and myocardial oxygen demand produced by central sympathetic stimulation in pentobarbital-anesthetized Wistar rats.
Negative_regulation (inhibitor) of cholinesterase in sympathetic
8) Confidence 0.59 Published 1999 Journal Clin. Auton. Res. Section Abstract Doc Link 10225612 Disease Relevance 0 Pain Relevance 0.16
In rat fundus homogenates, metoclopramide and ranitidine showed a significant cholinesterase inhibition.
Negative_regulation (inhibition) of cholinesterase in fundus
9) Confidence 0.59 Published 1988 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 3245740 Disease Relevance 0 Pain Relevance 0.08
The data suggest that some alterations in the brain functional state may outlast the CVP induced depression of cholinesterase activity.
Negative_regulation (depression) of cholinesterase in brain associated with depression
10) Confidence 0.59 Published 1990 Journal Pol J Occup Med Section Abstract Doc Link 2130875 Disease Relevance 0.18 Pain Relevance 0.13
These results seem to cast a doubt on the generally held ACh release hypothesis for the action mechanism of metoclopramide on one hand, and suggest, on the other hand, that cholinesterase inhibition contributes to some extent to the gastrokinetic effects of metoclopramide and ranitidine.
Negative_regulation (inhibition) of cholinesterase
11) Confidence 0.59 Published 1988 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 3245740 Disease Relevance 0 Pain Relevance 0.07
Thus, the apparent histochemical diminution of endplate length after denervation was artefactual, probably due to loss of cholinesterase activity and impeded access of substrate.
Negative_regulation (loss) of cholinesterase
12) Confidence 0.59 Published 1984 Journal Neuroscience Section Abstract Doc Link 6738862 Disease Relevance 0.18 Pain Relevance 0.07
Morphine hydrochloride (10 mg/kg,i.p.) induced marked catalepsy in rats, which was associated with significantly enhanced striatal acetylcholine levels and reduced cholinesterase activity.
Negative_regulation (reduced) of cholinesterase associated with catalepsy and morphine
13) Confidence 0.59 Published 1979 Journal Neurosci. Lett. Section Abstract Doc Link 575200 Disease Relevance 0.27 Pain Relevance 0.59
In conclusion, the increases in endogenous acetylcholine induced by cholinesterase inhibition blunted the centrally-evoked increases in myocardial oxygen demand in anesthetized rats.
Negative_regulation (inhibition) of cholinesterase
14) Confidence 0.59 Published 1999 Journal Clin. Auton. Res. Section Abstract Doc Link 10225612 Disease Relevance 0 Pain Relevance 0.18
Effectiveness of alpha 2-adrenergic receptor stimulation in reducing the central toxicity following cholinesterase inhibition.
Negative_regulation (inhibition) of cholinesterase associated with toxicity
15) Confidence 0.58 Published 1992 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Title Doc Link 1352646 Disease Relevance 0.61 Pain Relevance 0.33
Paraoxon, an irreversible organophosphorus inhibitor of cholinesterase, produces a myopathy beginning at the neuromuscular junction in rat diaphragm muscles.
Negative_regulation (inhibitor) of cholinesterase in neuromuscular junction associated with muscle disease
16) Confidence 0.58 Published 1975 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1151764 Disease Relevance 0.10 Pain Relevance 0
Recent data indicate that the neurotoxic effects of organophosphate compounds, including those of the nerve agents VX and sarin, are not solely due to irreversible cholinesterase inhibition.
Negative_regulation (inhibition) of cholinesterase in nerve
17) Confidence 0.58 Published 1998 Journal Drug Chem Toxicol Section Abstract Doc Link 10028411 Disease Relevance 0 Pain Relevance 0.31
It seems that remifentanil dosage does not need to be changed in patients with butyrylcholinesterase deficiency.
Negative_regulation (deficiency) of butyrylcholinesterase associated with ultiva
18) Confidence 0.58 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 12401616 Disease Relevance 0 Pain Relevance 0.55
Cholinesterase inhibitors should be prescribed judiciously, and because these drugs carry a risk of serious adverse events, they should be continued only if the benefits outweigh the risks.
Negative_regulation (inhibitors) of Cholinesterase
19) Confidence 0.57 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2742897 Disease Relevance 0.35 Pain Relevance 0
Among these cases, 848 (84%) received a cholinesterase inhibitor in both the risk and reference periods, leaving 161 cases to inform our matched pairs analysis of individuals who had received a cholinesterase inhibitor in either the risk or reference period, but not both.
Negative_regulation (inhibitor) of cholinesterase
20) Confidence 0.57 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2742897 Disease Relevance 0.08 Pain Relevance 0

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