INT116900

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.00
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (PRF1) extracellular region (PRF1) cytoplasmic membrane-bounded vesicle (PRF1)
plasma membrane (PRF1)
Anatomy Link Frequency
T cells 3
PRF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 92 99.28 Very High Very High Very High
chemokine 48 87.00 High High
drug abuse 1 79.12 Quite High
depression 1 78.44 Quite High
headache 1 72.96 Quite High
Pain 2 70.56 Quite High
cytokine 16 67.12 Quite High
Inflammation 19 67.08 Quite High
addiction 2 66.96 Quite High
Inflammatory response 5 65.76 Quite High
Disease Link Frequency Relevance Heat
Cerebral Malaria 39 99.88 Very High Very High Very High
Low Back Pain 104 99.28 Very High Very High Very High
Malaria 48 98.64 Very High Very High Very High
Chronic Fatigue Syndrome 78 95.28 Very High Very High Very High
Epstein-barr Virus 32 92.72 High High
Cytomegalovirus Infection 42 92.00 High High
Disease 38 90.84 High High
Infection 53 88.68 High High
Sprains And Strains 3 82.08 Quite High
Appetite Loss 1 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other more recent studies, using malaria animal models, showed that experimental cerebral malaria (ECM) was induced in perforin-deficient mice (PFP-/-) after adoptive transfer of cytotoxic CD8+ T cells from infected C57BL/6 mice, which were directed to the brains of PFP-/-mice.
Positive_regulation (induced) of perforin in T cells associated with malaria and cerebral malaria
1) Confidence 0.49 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.24 Pain Relevance 0.32
Some studies have suggested that these decreases in NK function may involve low levels of granzymes, perforin proteins and increases in the expression of the granzyme gene GZMA [6,8].
Positive_regulation (increases) of perforin
2) Confidence 0.45 Published 2010 Journal J Transl Med Section Body Doc Link PMC2829521 Disease Relevance 1.47 Pain Relevance 0.26
For functional characterization of CD8+ CD28- T cells in AS patients, flow cytometric single cell analysis was used, and the intracellular accumulation of perforin and IFN-?
Positive_regulation (accumulation) of perforin in T cells associated with spinal inflammation
3) Confidence 0.08 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 0.70 Pain Relevance 0.53
The Mann–Whitney test was used to compare the percentages of CD8+CD28- T cells between AS patients and healthy controls, the percentages of perforin or IFN-?
Positive_regulation (percentages) of perforin in T cells associated with spinal inflammation
4) Confidence 0.07 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 0.50 Pain Relevance 0.29
CD4+CD28null cells were separated by flow cytometry and assessed for antigen recognition using upregulation of interferon-gamma and perforin mRNA transcription as criteria for activation.
Positive_regulation (upregulation) of perforin mRNA
5) Confidence 0.00 Published 2004 Journal Circulation Section Body Doc Link 14993140 Disease Relevance 0.08 Pain Relevance 0

General Comments

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