INT116928

Context Info Confidence 0.20 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Title Documents 1 Total Number 1 Disease Relevance 0.15 Pain Relevance 0.46

cytosol (PTK2, JUN) nucleus (PTK2, JUN) nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN) DNA binding (JUN)

Anatomy Link Frequency THP-1 1 PTK2 (Homo sapiens) JUN (Homo sapiens)

Pain Link Frequency Relevance Heat Kappa opioid receptor 8 99.50 Opioid 1 96.80 opioid receptor 1 92.56 agonist 2 85.80

Disease Link Frequency Relevance Heat Adhesions 2 100.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Kappa-opioid receptor signals through Src and focal adhesion kinase to stimulate c-Jun N-terminal kinases in transfected COS-7 cells and human monocytic THP-1 cells.

focal adhesion kinase Positive_regulation (stimulate) of c-Jun in THP-1 associated with kappa opioid receptor and adhesions

1) Confidence 0.20 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 14996948 Disease Relevance 0.15 Pain Relevance 0.46

General Comments

This test has worked.