INT116938

Context Info Confidence 0.10 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 0.41

cytoplasm (GLI2, MAPK8) nucleus (GLI2, MAPK8) nucleoplasm (MAPK8) cell differentiation (GLI2) mitochondrion (MAPK8) intracellular (GLI2)

Anatomy Link Frequency THP-1 2 GLI2 (Homo sapiens) MAPK8 (Homo sapiens)

Pain Link Frequency Relevance Heat Kappa opioid receptor 8 100.00 agonist 2 100.00 opioid receptor 1 96.68 Opioid 1 92.04

Disease Link Frequency Relevance Heat Adhesions 2 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Stimulation of the THP-1 cells with a kappa-opioid receptor-selective agonist exerted a Gi-dependent activation of c-Jun N-terminal kinase (JNK).

Positive_regulation (Stimulation) of THP-1 in THP-1 Positive_regulation (activation) of JNK associated with agonist and kappa opioid receptor

1) Confidence 0.10 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14996948 Disease Relevance 0.07 Pain Relevance 0.41

General Comments

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