INT11696

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Context Info
Confidence 0.78
First Reported 1980
Last Reported 2010
Negated 3
Speculated 5
Reported most in Abstract
Documents 50
Total Number 57
Disease Relevance 41.25
Pain Relevance 14.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-A)
Anatomy Link Frequency
leukocyte 10
CD86 3
T cells 3
lymph node 2
KG-1 2
HLA-A (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 75 100.00 Very High Very High Very High
melanocortin 1 receptor 4 100.00 Very High Very High Very High
Arthritis 180 99.52 Very High Very High Very High
rheumatoid arthritis 139 99.28 Very High Very High Very High
Multiple sclerosis 29 99.28 Very High Very High Very High
cINOD 15 99.08 Very High Very High Very High
local anesthetic 24 99.04 Very High Very High Very High
psoriasis 81 98.84 Very High Very High Very High
Inflammatory response 6 98.62 Very High Very High Very High
Neuritis 22 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 144 100.00 Very High Very High Very High
Low Back Pain 76 100.00 Very High Very High Very High
Cancer 300 99.96 Very High Very High Very High
Dengue Hemorrhagic Fever 417 99.84 Very High Very High Very High
Fracture Healing 64 99.64 Very High Very High Very High
Melanoma 34 99.58 Very High Very High Very High
Malignant Neoplastic Disease 22 99.56 Very High Very High Very High
Hookworm Infection 140 99.34 Very High Very High Very High
Rheumatoid Arthritis 141 99.28 Very High Very High Very High
Demyelinating Disease 29 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human leukocyte antigen (HLA) B27, which has been characteristic of ankylosing spondylitis, was also present in this case.
Gene_expression (present) of HLA in leukocyte associated with spinal inflammation
1) Confidence 0.78 Published 2001 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 11855083 Disease Relevance 1.29 Pain Relevance 0.32
HLA-DM, -DO (peptide loading), HLA-DP, -DQ, -DR (antigen presentation), granzyme B, H, perforin and FCGR3A (CD16) (cytotoxicity) displayed increased expression, as did CD8, a marker of cytotoxic T-lymphocytes, while HLA-A and -C expression were not increased by NSAID treatment.
Gene_expression (expression) of HLA-A in cytotoxic T-lymphocytes associated with cinod
2) Confidence 0.75 Published 2008 Journal Cancer Immun. Section Abstract Doc Link 18307280 Disease Relevance 0.81 Pain Relevance 0.60
The levels of serum total immunoglobulins and IgG subclasses and the frequencies of the immune response genes at the IGH@, HLA-A, -B, -DRB1, C4A, and C4B loci were analyzed in the patients and in control subjects.
Spec (analyzed) Gene_expression (levels) of HLA-A
3) Confidence 0.75 Published 2008 Journal J Pain Section Abstract Doc Link 18417422 Disease Relevance 1.52 Pain Relevance 0.60
All 3 patients carried the human leukocyte antigen (HLA) DQB1*0303 allele and tested positive for anti-Ro antibodies, but not for anti-cardiolipin antibodies.
Gene_expression (carried) of HLA in leukocyte
4) Confidence 0.68 Published 2002 Journal J Clin Rheumatol Section Abstract Doc Link 17041358 Disease Relevance 0.97 Pain Relevance 0.53
HLA-A*02 was the most frequent specificity at HLA-A locus in both groups of haplotypic associations (B*2702 and B*2705) and no difference in distribution of HLA-A genes was observed between two groups.
Gene_expression (locus) of HLA-A
5) Confidence 0.65 Published 2008 Journal Reumatizam Section Abstract Doc Link 19024262 Disease Relevance 0.08 Pain Relevance 0.08
HLA-A*02 was the most frequent specificity at HLA-A locus in both groups of haplotypic associations (B*2702 and B*2705) and no difference in distribution of HLA-A genes was observed between two groups.
Gene_expression (locus) of HLA-A
6) Confidence 0.65 Published 2008 Journal Reumatizam Section Abstract Doc Link 19024262 Disease Relevance 0.08 Pain Relevance 0.08
These included genes encoding proteins involved in intracellular antigen processing and transport for eventual surface presentation to immune cells (PSMB8, TAP1), antigen presentation proteins, including HLA class I molecules (HLA-A, HLA-C, HLA-F, and HLA-G) and HLA class II molecules (HLA-DRB1, DRB4, DRB5, DPA1, and DPB1), cytokines involved in the recruitment of monocytes (SCYA3, SCYA4, CD14), and cytokine receptors (IL1R2, IL4R, and IL6R).
Gene_expression (molecules) of HLA-A in immune cells associated with cytokine
7) Confidence 0.65 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.31 Pain Relevance 0.12
HLA-A*02 was the most frequent specificity at HLA-A locus in both groups of haplotypic associations (B*2702 and B*2705) and no difference in distribution of HLA-A genes was observed between two groups.
Gene_expression (locus) of HLA-A
8) Confidence 0.65 Published 2008 Journal Reumatizam Section Abstract Doc Link 19024262 Disease Relevance 0.08 Pain Relevance 0.08
Several genes that probably play a role in the inflammatory response characteristic of early stages of fracture healing (FCGRT, Basigin, HLA-A, and CD74) were found to be overexpressed in the PF7 and PF10 ESTs (Table 2).
Gene_expression (overexpressed) of HLA-A associated with fracture healing and inflammatory response
9) Confidence 0.65 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1578570 Disease Relevance 0.38 Pain Relevance 0.17
On the other hand, the distribution of HLA-A alleles on Bw60-bearing haplotypes was significantly different from the distribution of A alleles on Bw60 haplotypes in the general population (P less than 0.0005).
Gene_expression (distribution) of HLA-A
10) Confidence 0.65 Published 1989 Journal Arthritis Rheum. Section Abstract Doc Link 2789045 Disease Relevance 0.73 Pain Relevance 0.73
HLA-A and B-antigens were determined in 22 patients with acute and in 65 patients with chronic pancreatitis as well as in 165 healthy controls.
Spec (determined) Gene_expression (determined) of HLA-A associated with chronic pancreatitis
11) Confidence 0.65 Published 1980 Journal Z Gastroenterol Section Abstract Doc Link 7456561 Disease Relevance 0.25 Pain Relevance 0.25
The distribution of HLA-A alleles on the B27-bearing haplotypes in AS patients was not significantly different from that in normal controls.
Gene_expression (distribution) of HLA-A associated with spinal inflammation
12) Confidence 0.65 Published 1989 Journal Arthritis Rheum. Section Abstract Doc Link 2789045 Disease Relevance 0.73 Pain Relevance 0.73
The levels of serum total immunoglobulins and IgG subclasses and the frequencies of the immune response genes at the IGH@, HLA-A, -B, -DRB1, C4A, and C4B loci were analyzed in the patients and in control subjects.
Spec (analyzed) Gene_expression (analyzed) of HLA-A
13) Confidence 0.58 Published 2008 Journal J Pain Section Abstract Doc Link 18417422 Disease Relevance 1.62 Pain Relevance 0.58
Interestingly, the RAMOS cell line expressed higher levels of HLA-A and HLA-E than human lymph node, suggesting a possible option for disrupting the antigen-recognition/representation pathways: selectively down-regulating key members instead of quenching all of which in malignantly transformed cells.
Gene_expression (levels) of HLA-A in lymph node
14) Confidence 0.58 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1522023 Disease Relevance 0.16 Pain Relevance 0
Interestingly, the RAMOS cell line expressed higher levels of HLA-A and HLA-E than human lymph node, suggesting a possible option for disrupting the antigen-recognition/representation pathways: selectively down-regulating key members instead of quenching all of which in malignantly transformed cells.
Gene_expression (expressed) of HLA-A in lymph node
15) Confidence 0.58 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1522023 Disease Relevance 0.16 Pain Relevance 0
The distributions of HLA antigens (A, B, and DR) were not demonstrably abnormal.
Gene_expression (distributions) of HLA
16) Confidence 0.49 Published 1985 Journal J Pediatr Orthop Section Abstract Doc Link 3873474 Disease Relevance 1.03 Pain Relevance 0.09
Non-HLA genes mapping outside the MHC region
Gene_expression (genes) of HLA
17) Confidence 0.49 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128931 Disease Relevance 1.23 Pain Relevance 0.56
The CTLs raised against these three HLA-A2+-restricted peptides could recognize naturally processed peptides from HLA-A2+ melanomas and from Cos7 cells cotransfected with MC1R and HLA-A2.
Gene_expression (cotransfected) of HLA-A2 associated with melanocortin 1 receptor and melanoma
18) Confidence 0.46 Published 1997 Journal Cancer Res. Section Abstract Doc Link 9331097 Disease Relevance 0.37 Pain Relevance 0.32
Reviewed were the clinical charts and human leukocyte antigen (HLA) profiles of all patients treated at a single teaching hospital fulfilling the features of this syndrome according to the definition of McCarty.
Gene_expression (profiles) of HLA in leukocyte associated with syndrome
19) Confidence 0.46 Published 2004 Journal Rheumatol. Int. Section Abstract Doc Link 12750942 Disease Relevance 0.52 Pain Relevance 0.05
Twenty-four (24) pretreated patients with relapsed high-risk resected The American Joint Committee on Cancer (AJCC) stage IIA-IV melanoma received adjuvant peptide vaccinations derived from the melanosomal antigens MelanA/MART1, MAGE-1, gp100, and tyrosinase, according to patient tumor-associated human leukocyte antigen (HLA) restricted antigen expression, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF).
Gene_expression (expression) of HLA in leukocyte associated with cancer and skin cancer
20) Confidence 0.46 Published 2007 Journal Cancer Biother. Radiopharm. Section Abstract Doc Link 17803450 Disease Relevance 0.80 Pain Relevance 0

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